Patents by Inventor Chi-Hao LUAN

Chi-Hao LUAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HECT E3 UBIQUITIN LIAGASE INHIBITORS AND USES THEREOF
    Publication number: 20240091219
    Abstract: Disclosed herein are compounds, compositions, and methods for inhibiting HECT E3 ubiquitin ligases. In some embodiments, the compounds are formulated as a pharmaceutical composition and administered to a subject in need thereof. In some embodiments, the subject in need thereof is diagnosed with a neurological disease or a cancer characterized by increased or ectopic HECT E3 ligase activity.
    Type: Application
    Filed: January 21, 2022
    Publication date: March 21, 2024
    Inventors: Hiroaki Kiyokawa, Rama K. Mishra, Chi-Hao Luan
  • Small Molecule Inhibitors That Block the Budding of Enveloped Viruses
    Publication number: 20230265069
    Abstract: Disclosed are compounds, compositions, and methods for treating an infection by an enveloped virus in a patient in need thereof. The disclosed compounds may be derived from prazole compounds and may inhibit or block the release of an enveloped virus from an infected cell. As such, the disclosed methods may include methods of treating a viral infection by administering the disclosed compounds or pharmaceutical compositions comprising the disclosed compounds.
    Type: Application
    Filed: April 23, 2021
    Publication date: August 24, 2023
    Inventors: Jonathan Leis, Chi-Hao Luan, James Edmund Audia
  • Ilaprazole for inhibiting the release of enveloped viruses from cells
    Patent number: 11666562
    Abstract: Disclosed are methods and compositions for treating an infection by an enveloped virus in a patient in need thereof. The methods include administering to the patient a compound that inhibits or blocks release of the enveloped virus from an infected cell. As such, the disclosed methods include methods of inhibiting or blocking release of an enveloped virus from a cell. The disclosed methods may include administering to the patient a prazole-type compound having a substituted (pyridin-2-yl)methylsulfinyl-benzimidazole core.
    Type: Grant
    Filed: April 2, 2021
    Date of Patent: June 6, 2023
    Assignee: Northwestern University
    Inventors: Jonathan Leis, Chi-Hao Luan
  • ILAPRAZOLE FOR INHIBITING THE RELEASE OF ENVELOPED VIRUSES FROM CELLS
    Publication number: 20210308114
    Abstract: Disclosed are methods and compositions for treating an infection by an enveloped virus in a patient in need thereof. The methods include administering to the patient a compound that inhibits or blocks release of the enveloped virus from an infected cell. As such, the disclosed methods include methods of inhibiting or blocking release of an enveloped virus from a cell. The disclosed methods may include administering to the patient a prazole-type compound having a substituted (pyridin-2-yl)methylsulfinyl-benzimidazole core.
    Type: Application
    Filed: April 2, 2021
    Publication date: October 7, 2021
    Inventors: Jonathan LEIS, Chi-Hao LUAN