Patents by Inventor Chi-Hsin Richard King

Chi-Hsin Richard King has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11554154
    Abstract: This invention relates to a method of treating Major depressive disorder by orally administering to a subject a composition containing a Radix Polygalae (Polygala tenuifolia Willd) extract (PDC-1421). A solid dosage form of PDC-1421 can be prepared into the gelatin capsule. The oral administration of PDC-1421 in healthy volunteers was safe and well-tolerated for the daily dose from 380 mg to 3800 mg. The composition can be administered chronically over at least 25 days; the daily dose is administered once per day, twice per day, or three times per day, wherein each dose is 380-760 mg of the botanical extraction.
    Type: Grant
    Filed: July 22, 2020
    Date of Patent: January 17, 2023
    Assignee: BIOLITE, INC.
    Inventors: Chi-Hsin Richard King, Hsien-Ming Wu, Howard Doong, Tsung-Shann Jiang
  • Publication number: 20220184167
    Abstract: This invention relates to a method of treating Attention-Deficit Hyperactivity Disorder by orally administering to a subject a composition containing a Radix Polygalae (Polygala tenuifolia Willd) extract (such as PDC-1421). A solid dosage form of the composition can be prepared into the gelatin capsule. The oral administration of the composition in healthy volunteers was safe and well-tolerated for the daily dose from 380 mg to 3800 mg. The composition can be administered chronically over at least 25 days; the daily dose is administered once per day, twice per day, or three times per day, wherein each dose is 380-760 mg of the botanical extract.
    Type: Application
    Filed: December 14, 2020
    Publication date: June 16, 2022
    Inventors: Chi-Hsin Richard KING, Hsien-Ming WU, Howard DOONG, Tsung-Shann JIANG
  • Publication number: 20220023373
    Abstract: This invention relates to a method of treating Major depressive disorder by orally administering to a subject a composition containing a Radix Polygalae (Polygala tenuifolia Willd) extract (PDC-1421). A solid dosage form of PDC-1421 can he prepared into the gelatin capsule. The oral administration of PDC-1421 in healthy volunteers was safe and well-tolerated for the daily dose from 380 mg to 3800 mg. The composition can be administered chronically over at least 25 days; the daily dose is administered once per day, twice per day, or three times per day, wherein each dose is 380-760 mg of the botanical extraction.
    Type: Application
    Filed: July 22, 2020
    Publication date: January 27, 2022
    Inventors: Chi-Hsin Richard KING, Hsien-Ming WU, Howard DOONG, Tsung-Shann JIANG
  • Patent number: 10004719
    Abstract: A spray-dried solid dispersion containing a pharmaceutical compound of formula (I) shown below and a pharmaceutically acceptable polymer, in which the pharmaceutical compound is dispersed in a polymer matrix formed from the pharmaceutically acceptable polymer. Further disclosed are methods for preparing such a solid dispersion and using it for treating hepatitis C virus infection and a pharmaceutical formulation containing same.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: June 26, 2018
    Assignee: TaiGen Biotechnology Co., Ltd.
    Inventors: Ming-Chu Hsu, Chu-Chung Lin, Chi-Hsin Richard King
  • Patent number: 9375406
    Abstract: A method of mobilizing cells expressing the type 4 CXC chemokine receptor into the peripheral circulation by contacting them with an effective amount of a compound of formula (I) shown below (each variable in the formula being defined in the Specification): The method can be used to treat cancer and myocardial infarction.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: June 28, 2016
    Assignee: Taigen Biotechnology Co., Ltd.
    Inventors: Ming-Chu Hsu, Ying-Huey Huang, Chi-Feng Yen, Chi-Hsin Richard King
  • Publication number: 20160090394
    Abstract: A method of mobilizing cells expressing the type 4 CXC chemokine receptor into the peripheral circulation by contacting them with an effective amount of a compound of formula (I) shown below (each variable in the formula being defined in the Specification): The method can be used to treat cancer and myocardial infarction.
    Type: Application
    Filed: September 30, 2014
    Publication date: March 31, 2016
    Inventors: Ming-Chu Hsu, Ying-Huey Huang, Chi-Feng Yen, Chi-Hsin Richard King
  • Patent number: 9023834
    Abstract: This invention relates to a pharmaceutical kit containing a lyophilized preparation of a pyrimidine compound described in the specification. Also disclosed is a lyophilization process for making this preparation.
    Type: Grant
    Filed: November 12, 2009
    Date of Patent: May 5, 2015
    Assignee: TaiGen Biotechnology Co., Ltd.
    Inventors: Chi-Feng Yen, Judy Yuan, Chi-Hsin Richard King
  • Patent number: 8658183
    Abstract: This invention relates to a parenteral formulation containing an effective amount of the compound of the following formula I: water, and an isotonic agent. Also disclosed is a method of treating an infectious disease by administering this formula to a subject via parenteral injection or infusion.
    Type: Grant
    Filed: August 9, 2007
    Date of Patent: February 25, 2014
    Assignee: Taigen Biotechnology Company, Ltd.
    Inventors: Lih-Huei Lee, Po-Yi Wu, Erkuan Sun, Chi-Hsin Richard King
  • Patent number: 8389560
    Abstract: This invention relates to macrocyclic compounds of formula (I) shown in the specification. These compounds can be used to treat hepatitis C virus infection.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: March 5, 2013
    Assignee: TaiGen Biotechnology Co., Ltd.
    Inventors: Chen-Fu Liu, Kuang-Yuan Lee, Pei-Chin Cheng, Yo-Chin Liu, Pin Lo, Kuo-Feng Tseng, Chih-Ming Chen, Chi-Hsin Richard King, Chu-Chung Lin
  • Patent number: 8372849
    Abstract: This invention relates to heterocyclic compounds of the formulas shown in the specification. It also relates to methods for treating inflammatory diseases or immune diseases, developmental or degenerative diseases, and tissue injuries with one of the heterocyclic compounds.
    Type: Grant
    Filed: November 3, 2008
    Date of Patent: February 12, 2013
    Assignee: Taigen Biotechnology Co., Ltd.
    Inventors: Chi-Feng Yen, Cheng-Kung Hu, Chang-Pin Huang, Ying-Huey Huang, Gholam Hossein Hakimelahi, Chi-Hsin Richard King
  • Patent number: 8211909
    Abstract: This invention relates to a method of treating infection by methicillin-nonsusceptibale bacteria, vancomycin-nonsusceptibale bacteria, penicillin-nonsusceptibale bacteria, clarithromycin-nonsusceptibale bacteria, or metronidazole-nonsusceptibale bacteria by administering to a subject in need thereof an effective amount of a compound of the following formula:
    Type: Grant
    Filed: September 8, 2008
    Date of Patent: July 3, 2012
    Assignee: TaiGen Biotechnology Co., Ltd.
    Inventors: Ming-Chu Hsu, Chi-Hsin Richard King, Shu-Jen Chen, Luke Lin
  • Publication number: 20120157492
    Abstract: This invention relates to a malic acid salt of (3S,5R)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid. Also disclosed is a method of treating bacterial infection by an effective amount of this salt.
    Type: Application
    Filed: July 10, 2009
    Publication date: June 21, 2012
    Inventors: Ming-Chu Hsu, Chi-Hsin Richard King, Judy Yuan, Wen-Chang Chen, Shan-Yen Chou, Bo Shi
  • Patent number: 8193206
    Abstract: This invention relates to a method for treating inflammatory diseases or immune diseases, developmental or degenerative diseases, or tissue injuries. The method includes administering to a subject in need thereof an effective amount of one or more compounds of formula (I). Each variable in this formula is defined in the specification.
    Type: Grant
    Filed: December 8, 2008
    Date of Patent: June 5, 2012
    Assignee: TaiGen Biotechnology Co., Ltd.
    Inventors: Chi-Feng Yen, Cheng-Kung Hu, Ming-Chen Chou, Chen-Tso Tseng, Chien-Huang Wu, Ying-Huey Huang, Shu-Jen Chen, Chi-Hsin Richard King
  • Publication number: 20110178107
    Abstract: This invention relates to compounds of Formula (I), (II), or (III) shown in the specification. These compounds can be used to treat hepatitis C virus infection.
    Type: Application
    Filed: January 19, 2011
    Publication date: July 21, 2011
    Applicant: TaiGen Biotechnology Co., Ltd.
    Inventors: Ching-Cheng Wang, Chen-Fu Liu, Kuang-Yuan Lee, Mei-Chun Lin, Shu-Huei Wang, Chi-Feng Yen, Yu-Hsuan Wang, Chi-Hsin Richard King
  • Publication number: 20110065737
    Abstract: This invention relates to macrocyclic compounds of formula (I) shown in the specification. These compounds can be used to treat hepatitis C virus infection.
    Type: Application
    Filed: September 15, 2009
    Publication date: March 17, 2011
    Applicant: TaiGen Biotechnology Co., Ltd.
    Inventors: Chen-Fu Liu, Kuang-Yuan Lee, Pei-Chin Cheng, Yo-Chin Liu, Pin Lo, Kuo-Feng Tseng, Chih-Ming Chen, Chi-Hsin Richard King, Chu-Chung Lin
  • Publication number: 20100152452
    Abstract: This invention relates to dialdehyde or dinitrile compounds, which are useful for stereoselective synthesis of piperidine, pyrrolidine, and azepane derivatives.
    Type: Application
    Filed: December 14, 2009
    Publication date: June 17, 2010
    Applicant: TaiGen Biotechnology Co., Ltd.
    Inventors: Shan-Yen Chou, Chi-Hsin Richard King
  • Publication number: 20100120719
    Abstract: This invention relates to a pharmaceutical kit containing a lyophilized preparation of a pyrimidine compound described in the specification. Also disclosed is a lyophilization process for making this preparation.
    Type: Application
    Filed: November 12, 2009
    Publication date: May 13, 2010
    Applicant: TaiGen Biotechnology Co., Ltd.
    Inventors: Chi-Feng Yen, Judy Yuan, Chi-Hsin Richard King
  • Publication number: 20100041697
    Abstract: This invention relates to a method of treating pneumonia by orally administering to a subject in need thereof a quinolone compound of formula (I), shown in the disclosure, at a daily dose of 2-30 mg/kg.
    Type: Application
    Filed: July 1, 2009
    Publication date: February 18, 2010
    Applicant: TaiGen Biotechnology Co., Ltd.
    Inventors: Kit Chiu, Luke Lin, Hao-Chen Tan, Chi-Hsin Richard King, Ming-Chu Hsu
  • Publication number: 20100004282
    Abstract: This invention relates to a method of treating infection by methicillin-nonsusceptibale bacteria, vancomycin-nonsusceptibale bacteria, penicillin-nonsusceptibale bacteria, clarithromycin-nonsusceptibale bacteria, or metronidazole-nonsusceptibale bacteria by administering to a subject in need thereof an effective amount of a compound of the following formula:
    Type: Application
    Filed: September 8, 2008
    Publication date: January 7, 2010
    Applicant: TaiGen Biotechnology Co., Ltd.
    Inventors: Ming-Chu Hsu, Chi-Hsin Richard King, Shu-Jen Chen, Luke Lin
  • Publication number: 20090286814
    Abstract: This invention relates to macrocyclic compounds of formula (I) or (II) shown in the specification. These compounds can be used to treat hepatitis C virus infection.
    Type: Application
    Filed: November 4, 2008
    Publication date: November 19, 2009
    Applicant: TaiGen Biotechnology Co., Ltd.
    Inventors: Chu-chung Lin, Kuang-Yuan Lee, Yo-chin Liu, Pin Lo, Rong-Jiunn Chen, Chen-Fu Liu, Chih-Ming Chen, Chi-Hsin Richard King