Patents by Inventor Chi-I Chiang

Chi-I Chiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineered Antibodies
    Publication number: 20250011426
    Abstract: Provided herein are multispecific antibodies containing a lambda charge pair introduced into the interface of a heavy chain and a light chain to reduce chain mispairing.
    Type: Application
    Filed: April 5, 2024
    Publication date: January 9, 2025
    Inventors: Yariv MAZOR, Vaheh OGANESYAN, Chi-I CHIANG, John David BAGERT, Xiuling LI, Sterling PAYNE, Even WALSENG, Ying FU, Chunlei WANG, Chunning YANG
  • Bispecific Engineered Antibodies
    Publication number: 20240417467
    Abstract: Provided herein is a multispecific antibody containing two antigen binding arms capable of binding to a first target and at least one antigen binding arm capable of binding to a second target. The multispecific antibody includes a lambda charge pair introduced into the interface of a heavy chain and a light chain to reduce chain mispairing.
    Type: Application
    Filed: April 6, 2024
    Publication date: December 19, 2024
    Inventors: Yariv MAZOR, Vaheh OGANESYAN, Chi-I CHIANG, John David BAGERT, Xiuling LI, Sterling PAYNE, Even WALSENG, Ying FU, Chunlei WANG, Chunning YANG
  • Trispecific Engineered Antibodies
    Publication number: 20240417468
    Abstract: Provided herein are trispecific antibodies containing three antigen binding arms each capable of binding to a different target, wherein each antigen binding arm contains a different lambda or kappa charge pair introduced into the interface of the respective heavy and light chains to reduce chain mispairing.
    Type: Application
    Filed: April 6, 2024
    Publication date: December 19, 2024
    Inventors: Yariv MAZOR, Vaheh OGANESYAN, Chi-I CHIANG, John David BAGERT, Xiuling LI, Sterling PAYNE, Even WALSENG, Ying FU, Chunlei WANG, Chunning YANG
  • Multispecific Anti-HIV Antibodies
    Publication number: 20220227845
    Abstract: The present invention provides a multispecific anti-HIV antibody that binds to multiple epitopes on HIV envelope protein, wherein the antibody comprises: i. an amino acid sequence that binds to a V1/V2 apex glycan epitope; ii. an amino acid sequence that binds to a V3-base glycan region epitope; iii. an amino acid sequence that binds to a CD4 binding site (CD4bs) epitope; iv. an amino acid sequence that binds to a gp120/gp41 interface epitope; and v. an amino acid sequence that binds to a membrane proximal external region (MPER) epitope.
    Type: Application
    Filed: October 18, 2019
    Publication date: July 21, 2022
    Inventors: Yuxing Li, James Steinhardt, Javier Guenaga, John R. Mascola, Tae-Wook Chun, Susan Moir, Chi-I Chiang