Abstract: Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as uveitis, retinopathies or macular degeneration, macular edema or other vitreoretinal diseases, inflammatory diseases such as autoimmune diseases, vascular leakage syndrome, edema, or diseases involving leukocyte activation, transplant rejection, respiratory diseases such as asthma, adult or acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease, and the like.

Abstract: The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.

Abstract: The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.

Abstract: A compound is provided, having the general structure (A): wherein A is an aryl or heteroaryl group, Y is a hydrophbic linking moiety, and L is a substitutent. The compound (A) can be used for treatment of various angiogenic-associated or hematologic disorders, such as myeloproliferative disorders in patients who do not respond to kinase-inhibition therapy that comprises administering currently used medications.

Abstract: A compound is provided, having the general structure (A): wherein A is an (un)substituted aryl or (un)substituted heteroaryl moiety, G is N, CH, or CR, R is an unsubstituted or substituted lower alkyl, Y is a hydrophobic linking moiety, and L is a substitutent as defined. The compound (A) can be used for treatment of various angiogenic and hematological-associated disorders, such as myeloproliferative disorder in patients who do not respond to kinase-inhibition therapy that comprises administering approved medications.

Abstract: A system for evacuating containers. The system includes a base housing defining a recess having a vacuum inlet port in communication with a vacuum source. An inner door is hinged to the base housing and is sized to cover the recess when in a closed position, and an outer door having a sealing member is hinged to close over the inner door. A vacuum nozzle extends at least partially between the inner and outer doors and is in communication with the recess. The inner and outer doors cooperate to retain a flexible container therebetween and around the nozzle so that the nozzle is positioned for fluid communication with an inside of the container. A removable drip pan is positioned to retain fluids drawn by the nozzle.

Abstract: The invention provides pyrimidine compounds having formula A. The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Src kinase family, and various other specific receptor and non-receptor kinases.

Abstract: The present invention makes use of the spherical sectors, semi-spheres, cylindrical or circular sections of a solid object or the surface of an object, and breaks them into components. If no such spherical sectors, semi-spheres, cylindrical or circular sections are available on the object, or the existing ones cannot be used for any reason, one can create some adequate ones under allowable circumstances. The puzzle will come into being when any of its broken down components can be shared with (interchanged with components of) other flat or spherical or circular or cylindrical surfaces. The idea of the present invention is rather simple, however it may be applied in a versatile manner.

Abstract: The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.

Abstract: The invention basically includes an outer layer made of flexible sheets of synthetic resinous or impervious materials, and/or rigid and/or semi-rigid materials while the wrapping of each article may be held inside the packaging system by flexible linkages. The portion of the wrapping that is not directly wrapping the article should be considered as the flange of the wrapping which will become the “linkage” in the glossary of this invention. The wrapping may be designed with openings for the protruded, fragile or sharp members of the article to avoid damage to these parts. The wrapping may be made as a closed cell and a negative pressure (vacuum) may be applied to securely grasp the article. For those articles that are not suited for tight wrap, certain fluids (e.g., air) may be provided to the inside of the sealed wrapping to counteract the inflation pressure at the outside of the wrapping.

Abstract: A system for evacuating containers. The system includes a base housing defining a recess having a vacuum inlet port in communication with a vacuum source. An inner door is hinged to the base housing and is sized to cover the recess when in a closed position, and an outer door having a sealing member is hinged to close over the inner door. A vacuum nozzle extends at least partially between the inner and outer doors and is in communication with the recess. The inner and outer doors cooperate to retain a flexible container therebetween and around the nozzle so that the nozzle is positioned for fluid communication with an inside of the container. A removable drip pan is positioned to retain fluids drawn by the nozzle.

Abstract: A method is described for controlling synchronous motor torque, utilizing a three-phase switch connected in a circuit to the input of a polyphase synchronous motor, and a switch control circuit. The switch control circuit senses the AC voltages input to the synchronous motor and produces signals that open and close the three-phase switch in phase with the input motor voltage, producing positive motor torque during normal operation. If input AC power is lost, the switch control circuit acts to prevent a reverse flow of high current from the motor from entering the power source bus. When input power, after a short time, returns, the switch control circuit acts to close the three-phase switch in such a manner as to permit only real power applied to the synchronous motor and thus positive torque that accelerates the motor speed and quickly restores the motor to synchronism with the input power source.