Patents by Inventor Chi-man Lawrence Wu

Chi-man Lawrence Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230221324
    Abstract: Disclosed herein are methods of detecting the presence or absence of exosomes, the method comprising detecting an exosomal biomarker in a sample obtained from a subject. Also disclosed herein is a system and a biosensor, each for detecting an exosomal biomarker as disclosed herein.
    Type: Application
    Filed: January 11, 2022
    Publication date: July 13, 2023
    Inventors: Linlin LIU, Abhimanyu THAKUR, Wing Kar LI, Youngjin LEE, Chi-Man Lawrence WU
  • Publication number: 20210373022
    Abstract: A method of detecting one or more exosomal protein in a sample includes the steps of: a) introducing the sample on at least a part of a first sensor having a nanostructure thereon, subjecting the first sensor to an optical radiation in a certain spectral range to produce a localized surface plasmon resonance and measuring an induced phase response; and b) introducing the sample on a second sensor having a nanostructure thereon, and obtaining an image via atomic force microscopy analysis with a probe functionalized with an antibody targeting the exosomal protein. A kit for detecting at least one exosomal protein in a sample includes a first sensor having a nanostructure thereon; a second sensor having a nanostructure thereon, and a probe functionalized with an antibody targeting the exosomal protein.
    Type: Application
    Filed: June 1, 2020
    Publication date: December 2, 2021
    Inventors: Youngjin Lee, Abhimanyu Thakur, Chi-Man Lawrence Wu, Guangyu Qiu, Chen Xu, Siu-Pang Ng, Tian Yang
  • Publication number: 20210311034
    Abstract: A sensor for liquid biopsy, its method of making, and its method of non-invasive use. The sensor includes a substrate with a surface functionalized with biotinylated antibodies. The biotinylated antibodies are arranged to engage with surface proteins on exosomes associated with malignant cancer cells such as glioma cells.
    Type: Application
    Filed: April 3, 2020
    Publication date: October 7, 2021
    Inventors: Youngjin Lee, Abhimanyu Thakur, Chi-Man Lawrence Wu, Chen Xu, Siu-Pang Ng
  • Patent number: 10677790
    Abstract: An optochemical detector and a method for fabricating an optochemical detector includes a light generation unit arranged to emit a light signal; a probe cell unit arranged to alter at least one physical characteristic of the light signal in response to an interaction with a target substance; and a light detection unit arranged to receive the light signal altered by the probe cell unit; wherein a detection of the target substance is characterized by a change in the at least one physical characteristic altered by the probe cell unit.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: June 9, 2020
    Assignee: City University of Hong Kong
    Inventors: Siu Pang Ng, Chi-man Lawrence Wu, Guang-yu Qiu, Hui Lun Anton Law
  • Publication number: 20180114649
    Abstract: A corrosion-free electrolyte for use in plasmonic-enhanced dye-sensitized solar cells includes ions of a plasmon-supporting metal, in particular iodide anions of the plasmon-supporting metal especially, but not exclusively, gold(I) diiodide anions ([AuI2]?) and/or gold(III) tetraiodide anions ([AuI4]?). Methods for preparing the electrolyte are also disclosed, as are methods for reducing the corrosion of plasmonic structures in plasmonic-enhanced dye-sensitized solar cells and for improving the efficiency of dye-sensitized solar cells, in particular plasmonic-enhanced dye-sensitized solar cells, by disposing the electrolyte between the electrodes.
    Type: Application
    Filed: October 25, 2016
    Publication date: April 26, 2018
    Inventors: Siu Pang Ng, Chi-man Lawrence Wu, Yu-qiao Fu, Chun Sing Lee
  • Publication number: 20180024127
    Abstract: An optochemical detector and a method for fabricating an optochemical detector includes a light generation unit arranged to emit a light signal; a probe cell unit arranged to alter at least one physical characteristic of the light signal in response to an interaction with a target substance; and a light detection unit arranged to receive the light signal altered by the probe cell unit; wherein a detection of the target substance is characterized by a change in the at least one physical characteristic altered by the probe cell unit.
    Type: Application
    Filed: July 20, 2016
    Publication date: January 25, 2018
    Inventors: Siu Pang Ng, Chi-man Lawrence Wu, Guang-yu Qiu, Hui Lun Anton Law
  • Patent number: 9322778
    Abstract: An optical sensing apparatus and a method for detecting characteristics of a sample.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: April 26, 2016
    Assignees: THE CHINESE UNIVERSITY OF HONG KONG, CITY UNIVERSITY OF HONG KONG
    Inventors: Ho Pui Ho, Shu Yuen Wu, Chi-Man Lawrence Wu, Siu Pang Ng, Siu Kai Kong
  • Patent number: 9287057
    Abstract: The present invention is concerned with a plasmonic enhanced tandem dye sensitized solar cell system. The system has plasmonic nanostructures integrated to both a photoanode and a photocathode for enhancing respective electron and hole carrier transfer.
    Type: Grant
    Filed: June 5, 2013
    Date of Patent: March 15, 2016
    Assignee: CITY UNIVERSITY OF HONG KONG
    Inventors: Siu-pang Ng, Chi-man Lawrence Wu, Chun-sing Lee
  • Publication number: 20150308950
    Abstract: An optical sensing apparatus and a method for detecting characteristics of a sample.
    Type: Application
    Filed: April 23, 2015
    Publication date: October 29, 2015
    Inventors: Ho Pui Ho, Shu Yuen Wu, Chi-Man Lawrence Wu, Siu Pang Ng, Siu Kai Kong
  • Patent number: 8953168
    Abstract: An optical sensing device including a source unit configured to generate a polychromatic light beam containing p-polarized beam and s-polarized beam; an interferometric unit configured to introduce birefringent retardation for generating optical path difference between the p-polarized beam and the s-polarized beam; a SPR sensing unit configured to receive both p-polarized beam and s-polarized beam and induce a SPR effect to the p-polarized beam associated with a target sample; and a detection unit for detecting target sample characteristics by obtaining an interference spectrum of the p-polarized beam and the s-polarized beam from the SPR sensing unit.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: February 10, 2015
    Assignees: City University of Hong Kong, The Chinese University of Hong Kong
    Inventors: Shu Yuen Wu, Ho Pui Ho, Chi-man Lawrence Wu, Siu-pang Ng
  • Publication number: 20140360564
    Abstract: The present invention is concerned with a plasmonic enhanced tandem dye sensitized solar cell system. The system has plasmonic nanostructures integrated to both a photoanode and a photocathode for enhancing respective electron and hole carrier transfer.
    Type: Application
    Filed: June 5, 2013
    Publication date: December 11, 2014
    Inventors: Siu-pang NG, Chi-man Lawrence WU, Chun-sing LEE
  • Publication number: 20130329230
    Abstract: An optical sensing device including a source unit configured to generate a polychromatic light beam containing p-polarized beam and s-polarized beam; an interferometric unit configured to introduce birefringent retardation for generating optical path difference between the p-polarized beam and the s-polarized beam; a SPR sensing unit configured to receive both p-polarized beam and s-polarized beam and induce a SPR effect to the p-polarized beam associated with a target sample; and a detection unit for detecting target sample characteristics by obtaining an interference spectrum of the p-polarized beam and the s-polarized beam from the SPR sensing unit.
    Type: Application
    Filed: June 8, 2012
    Publication date: December 12, 2013
    Applicants: City University of Hong Kong, The Chinese University of Hong Kong
    Inventors: Shu Yuen Wu, Ho Pui Ho, Chi-man Lawrence Wu, Siu-pang Ng