Abstract: The present invention provides a culture device for biochemical testing. The culture device includes a first plate and a second plate, and the second plate is opposite to the first plate. The first plate and the second plate form an incubation cassette and a supply channel, and the incubation cassette is connected to the supply channel by a microstructure. The present invention can provide side views of multi-layered cellular samples, such as corneal tissue, and can be easily combined with other techniques for more comprehensive detection. In addition, applicable industries or products include: cell culture devices, in vitro clinical specimen culture, 3D cell culture, high-throughput drug screening, tumor invasion assessment, cell biology research, personalized precision medicine, etc.

Abstract: An atomizer for adaptively generating pharmaceutical aerosols of different particle sizes is illustrated, which comprises a sensor module, a waveform pattern determination module, a high-frequency oscillation circuit, a signal modulation module, a piezoelectric device and a porous screen. The sensor module senses a body state of the patient, wherein the body state includes a breathing state. The waveform pattern determination module generates a modulation control signal according to the body state. The high-frequency oscillation circuit provides a high-frequency oscillation signal. The signal modulation module modulates the high-frequency oscillation signal by using the modulation control signal to generate a vibration signal. The piezoelectric device vibrates according to the vibration signal. According to vibration of the piezoelectric device, the porous screen presses the liquid medicine through a plurality of holes of the porous screen to generate a plurality of pharmaceutical aerosols.

Abstract: A respiratory drug delivery device and a method for automating drug delivery are provided. The respiratory drug delivery device may be utilized for delivering a drug to a patient's respiratory tract. The respiratory drug delivery device comprises an inhalation element, an air pipe, a sound sensor, and a drug delivery module, the drug delivery module delivers an aerosolized medicine when the patient inhales based on a sound signal.

Abstract: A method and apparatus for detecting a respiratory function are provided. The method includes training a plurality of classification models, receiving a breathing sound by a sound receiver to generate a breathing signal, and classifying the breathing signal by each of the trained classification models to obtain a classification result corresponding to each of the classification models.

Abstract: The present invention provides a plasma aerosol inhalation device and a method for thinning the sputum. Various radicals generated by plasma can be inhaled in an aerosol form and delivered to the respiratory system for desired efficacy.

Abstract: A method is provided to prepare one or more microfluidic channels on a receptive material by applying an image-forming material to a heat sensitive thermoplastic receptive material in a designed pattern and heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%. In an alternative aspect, the microfluidic channels on receptive material are prepared by etching a designed pattern into a heat sensitive thermoplastic material support and then heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%.

Abstract: A method is provided to prepare one or more microfluidic channels on a receptive material by applying an image-forming material to a heat sensitive thermoplastic receptive material in a designed pattern and heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%. In an alternative aspect, the microfluidic channels on receptive material are prepared by etching a designed pattern into a heat sensitive thermoplastic material support and then heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%.

Abstract: A method is provided to prepare a plurality of microwells suitable for the formation of embryoid bodies from embryonic stem cells. The method requires applying an image-forming material to a heat sensitive thermoplastic material in a designed pattern and heating the material under conditions that reduce the size of the receptive material by at least about 60% to create a mold. A polymer such as PDMS is then applied to the mold and removed to form the microwells. In an alternative aspect, the plurality of microwells on receptive material are prepared by etching a microwell designed pattern into a heat sensitive thermoplastic material support and then heating the material under conditions that reduce the size of the receptive material by at least about 60%.

Abstract: A method is provided to prepare one or more microfluidic channels on a receptive material by applying an image-forming material to a heat sensitive thermoplastic receptive material in a designed pattern and heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%. In an alternative aspect, the microfluidic channels on receptive material are prepared by etching a designed pattern into a heat sensitive thermoplastic material support and then heating the material under conditions that reduce the size of the thermoplastic receptive material by at least about 60%.

Abstract: This invention provides compositions for differentiating an isolated embryonic stem cell or an isolated embryoid body into neuronal progenitor cells and methods for using same.

Abstract: Methods and compositions for aligning cell growth is provided by this invention by contacting at least one isolated cell with a device, wherein the device comprises a plurality of continuously orientating substantially parallel structures on the surface of the device, and culturing the cell under conditions that favor division of the at least one cell into a population of cells, thereby growing the population of cells in a substantially parallel orientation.