Patents by Inventor Chi Tuan
Chi Tuan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11471562Abstract: A method is provided for producing a live cartilaginous material useful for implantation into a patient. A method of treating a patient comprising implanting a cartilaginous material prepared according to the provided method in an anatomical site in a patient also is provided.Type: GrantFiled: April 9, 2019Date of Patent: October 18, 2022Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Hang Lin, Rocky Sung Chi Tuan, Yuanheng Yang
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Publication number: 20220243157Abstract: Disclosed herein are various bioreactor devices that mimic the mammalian joint. The bioreactor device can include a series of bioreactor chambers that contain different components of the joint, such as bone, cartilage, synovium, nerve and ligament. At least two different nutrient fluid circulation systems connect subsets of the bioreactor chambers to differentially supply nutrient fluids at concentrations optimized for the tissue that the fluid nourishes. For example, relatively hypoxic fluid can be supplied to synovium and cartilage to mimic oxygenation in the joint compartment, but normoxic fluid can be supplied to the bone and other components that have an arterial supply that provides higher oxygen concentrations. One or more or all of the bioreactor chambers can be supplied with separate inlets through which perturbation agents (such as drugs or other agents) can be introduced to model the effect of the perturbations on different components of the system.Type: ApplicationFiled: April 19, 2022Publication date: August 4, 2022Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Hang Lin, Rocky Sung Chi Tuan, Michael Seth Gold
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Patent number: 11339362Abstract: Disclosed herein are various bioreactor devices that mimic the mammalian joint. The bioreactor device can include a series of bioreactor chambers that contain different components of the joint, such as bone, cartilage, synovium, nerve and ligament. At least two different nutrient fluid circulation systems connect subsets of the bioreactor chambers to differentially supply nutrient fluids at concentrations optimized for the tissue that the fluid nourishes. For example, relatively hypoxic fluid can be supplied to synovium and cartilage to mimic oxygenation in the joint compartment, but normoxic fluid can be supplied to the bone and other components that have an arterial supply that provides higher oxygen concentrations. One or more or all of the bioreactor chambers can be supplied with separate inlets through which perturbation agents (such as drugs or other agents) can be introduced to model the effect of the perturbations on different components of the system.Type: GrantFiled: November 16, 2018Date of Patent: May 24, 2022Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Hang Lin, Peter Alexander, Riccardo Lucca Gottardi, Rocky Sung Chi Tuan
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Publication number: 20200368289Abstract: Provided herein is a ligament ECM soluble fraction useful for the growth and regrowth of ligament tissue. Methods of preparation of the soluble fractions and use of the soluble fractions in growth or regrowth of ligament tissue also are provided.Type: ApplicationFiled: February 20, 2019Publication date: November 26, 2020Inventors: Riccardo Luca Gottardi, Benjamin Burke Rothrauff, Rocky Sung Chi Tuan, Shinsuke Kihara
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Publication number: 20200270561Abstract: Disclosed mechanical stimulator systems can maintain the sterility of biological samples within a multi-well plate while mechanically stimulating the samples. The systems disclosed herein allow for the individual activation by mechanical compression of a high number of samples at the same time, while maintaining sterility of the samples. The well plates, guides, actuations pistons, and other components of the disclosed systems can be configured to be contained in or adjacent to an incubator that can control properties such as gas levels and temperature while at the same time allowing for the mechanical actuation of the biological samples.Type: ApplicationFiled: October 19, 2018Publication date: August 27, 2020Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Fondazione Ri.MEDInventors: Davide Marino, Riccardo Gottardi, Rocky Sung Chi Tuan
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Publication number: 20190307922Abstract: A method is provided for producing a live cartilaginous material useful for implantation into a patient. A method of treating a patient comprising implanting a cartilaginous material prepared according to the provided method in an anatomical site in a patient also is provided.Type: ApplicationFiled: April 9, 2019Publication date: October 10, 2019Inventors: Hang Lin, Rocky Sung Chi Tuan, Yuanheng Yang
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Publication number: 20190276784Abstract: Disclosed herein are various bioreactor devices that mimic the mammalian joint. The bioreactor device can include a series of bioreactor chambers that contain different components of the joint, such as bone, cartilage, synovium, nerve and ligament. At least two different nutrient fluid circulation systems connect subsets of the bioreactor chambers to differentially supply nutrient fluids at concentrations optimized for the tissue that the fluid nourishes. For example, relatively hypoxic fluid can be supplied to synovium and cartilage to mimic oxygenation in the joint compartment, but normoxic fluid can be supplied to the bone and other components that have an arterial supply that provides higher oxygen concentrations. One or more or all of the bioreactor chambers can be supplied with separate inlets through which perturbation agents (such as drugs or other agents) can be introduced to model the effect of the perturbations on different components of the system.Type: ApplicationFiled: November 16, 2018Publication date: September 12, 2019Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Hang Lin, Peter Alexander, Riccardo Lucca Gottardi, Rocky Sung Chi Tuan
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Publication number: 20190076840Abstract: Disclosed herein are various bioreactor devices and systems for growing cellular material, and related methods of growing cellular material. In some cases, a system can include a bioreactor system having one or more wells with at least one fluidic passageway coupled to each well to feed fluids to biological material being developed inside the well. In some cases, a bioreactor system can include a main body comprising the perimeter of the well and the fluidic passageways, a cover that forms the top of the well and provides optical access into the well, and a base that forms the bottom surface of the well. The cover and base can be attached and detached from the main body to seal the well closed and to physically access the contents of the well.Type: ApplicationFiled: October 6, 2016Publication date: March 14, 2019Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Riccardo Gottardi, Peter Alexander, Bryan Romell, Rocky Sung Chi Tuan
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Publication number: 20170342273Abstract: An exemplary embodiment of the present invention provides a filler comprising a silica core, a first layer in communication with the core, and a second layer in communication with the first layer. The presence of the second layer can decrease the coefficient of thermal expansion, decrease the composite modulus, and increase the glass transition temperature of the modulus as compared to fillers without a second layer.Type: ApplicationFiled: May 30, 2017Publication date: November 30, 2017Inventors: Chia-Chi Tuan, Kyoung-Sik Moon, Ching Ping Wong
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Publication number: 20160129155Abstract: Described herein are methods of fabricating human cell-based engineered musculoskeletal tissues (hCEMTs) using three dimensional fabrication technology that involves injectable materials with in situ polymerization/solidification capability and/or solid free-form fabrication. Also described is the usage of hCEMTs for tissue repair and drug testing.Type: ApplicationFiled: November 6, 2015Publication date: May 12, 2016Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Hang Lin, Rocky Sung Chi Tuan
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Publication number: 20050176953Abstract: The present invention discloses a phenanthrene derivative having the following structure: wherein Ar1 and Ar2 independently are phenyl, nathphyl, heterocyclic group, polycyclic aromatic or polycyclic heterocyclic group with at least one conjugated substituent. The conjugated substituent can be an electron withdrawing group or electron donating group. The phenanthrene derivatives have semiconductor properties of electron transfer, electroluminescence (EL), and photoluminescence (PL). Intermolecular stacking can be avoided and electron-luminescent emission stability is enhanced when the derivatives are applied as a light-emitting material in organic EL devices due to the presence of the two stereo cyclopentane rings, such as a host compound or a dopant emitting blue light.Type: ApplicationFiled: February 4, 2005Publication date: August 11, 2005Applicant: Industrial Technology Research InstituteInventors: Chi Tuan, Zong-Wei Tsai, Ching-Ian Chao, Shyue-Ming Jang, Chia-Kuo Yen
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Patent number: 6710589Abstract: A threadless docking fixture for removably mounting a test device in functional electrical engagement with a test head on a parametric semiconductor wafer testing system. The threadless docking fixture comprises a housing in which is mounted the test device. The housing is fitted with a pivoting lock handle which terminates in a pair of lock plates rotatably attached to opposite sides of the housing. An arcuate lock flange on each lock plate us removably engages a lock rod which extends from a corresponding one of a pair of anchor plates which are mounted on the test head of the wafer testing system. Accordingly, each lock flange engages the corresponding lock rod and the test device is mounted in functional electrical engagement with the test head as the handle is pivoted from an unlock to a lock position.Type: GrantFiled: June 19, 2002Date of Patent: March 23, 2004Assignee: Taiwan Semiconductor Manufacturing Co., Ltd.Inventors: Yung-Chi Tuan, Jewin Chang
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Publication number: 20030234643Abstract: A threadless docking fixture for removably mounting a test device in functional electrical engagement with a test head on a parametric semiconductor wafer testing system. The threadless docking fixture comprises a housing in which is mounted the test device. The housing is fitted with a pivoting lock handle which terminates in a pair of lock plates rotatably attached to opposite sides of the housing. An arcuate lock flange on each lock plate removably engages a lock rod which extends from a corresponding one of a pair of anchor plates which are mounted on the test head of the wafer testing system. Accordingly, each lock flange engages the corresponding lock rod and the test device is mounted in functional electrical engagement with the test head as the handle is pivoted from an unlock to a lock position.Type: ApplicationFiled: June 19, 2002Publication date: December 25, 2003Applicant: Taiwan Semiconductor Manufacturing Co., Ltd.Inventors: Yung-Chi Tuan, Jewin Chang