Patents by Inventor Chi-Wan Lee

Chi-Wan Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRIAZINONE AND DIAZINONE DERIVATIVES USEFUL AS HSP90 INHIBITORS
    Publication number: 20100298331
    Abstract: The present invention relates to compounds according to formulae (IA) to (ID) and compositions that inhibit the activity of Hsp90. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a compound of the invention, or a composition comprising such a compound.
    Type: Application
    Filed: March 24, 2008
    Publication date: November 25, 2010
    Inventors: Chi-Wan Lee, Teresa Przewloka, Weiwen Ying, Minghu Song, Zhenjian Du, Kevin Foley, Dan Zhou, Shuzhen Qin
  • Triazole compounds that modulate Hsp90 activity
    Patent number: 7825148
    Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
    Type: Grant
    Filed: November 17, 2005
    Date of Patent: November 2, 2010
    Assignee: Synta Pharmaceuticals Corp.
    Inventors: Weiwen Ying, David James, Shijie Zhang, Teresa Przewloka, Junghyun Chae, Dinesh U. Chimmanamada, Chi-Wan Lee, Elena Kostik, Howard P. Ng, Kevin Foley, Zhenjian Du, James Barsoum
  • Triazole compounds that modulate HSP90 activity
    Patent number: 7662813
    Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
    Type: Grant
    Filed: August 17, 2006
    Date of Patent: February 16, 2010
    Assignee: Synta Pharmaceuticals Corp.
    Inventors: Weiwen Ying, David James, Shijie Zhang, Teresa Przewloka, Elena Kostik, Junghyun Chae, Howard P Ng, Zhenjian Du, James Barsoum, Dinesh Chimmanamada, Chi-Wan Lee, Kevin Foley
  • Synthesis of triazole compounds that modulate HSP90 activity
    Publication number: 20080125587
    Abstract: The present invention provides novel methods of preparing triazole compounds which inhibit the activity of Hsp90. One embodiment of the invention is directed to methods for preparing a triazole compound represented by the following Structural Formula: or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising the steps of: a) reacting an amide represented by the following Structural Formula: with a thionation reagent to form a thioamide; b) reacting the thioamide of step a) with hydrazine to form a hydrazonamide; c) reacting the hydrazonamide of step b) with a carbonylation or a thiocarbonylation reagent. In one embodiment, the present invention is a method of synthesis of a compound of formula (IA) or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising reacting a compound of formula (IIA) with an oxidizing agent, thereby producing a compound of formula (IA).
    Type: Application
    Filed: May 25, 2007
    Publication date: May 29, 2008
    Inventors: Dinesh U. Chimmanamada, Chi-Wan Lee, David James, Shijie Zhang, Weiwen Ying, Junghyun Chae, Teresa Przewloka
  • Triazole compounds that modulate HSP90 activity
    Publication number: 20080090887
    Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
    Type: Application
    Filed: May 25, 2007
    Publication date: April 17, 2008
    Inventors: Weiwen Ying, David James, Shijie Zhang, Junghyun Chae, Teresa Przewloka, Howard Ng, Hao Li, Zachary Demko, Dinesh Chimmanamada, Chi-wan Lee, Zhenjian Du, Kevin Foley, Minghu Song, Lijun Sun, Keizo Koya, Dan Zhou, Shuzhen Qin
  • Triazole compounds that modulate HSP90 activity
    Publication number: 20070155809
    Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
    Type: Application
    Filed: August 17, 2006
    Publication date: July 5, 2007
    Inventors: Weiwen Ying, David James, Shijie Zhang, Teresa Przewloka, Elena Kostik, Junghyun Chae, Howard Ng, Zhenjian Du, James Barsoum, Dinesh Chimmanamada, Chi-Wan Lee, Kevin Foley
  • Triazole compounds that modulate Hsp90 activity
    Publication number: 20060167070
    Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
    Type: Application
    Filed: November 17, 2005
    Publication date: July 27, 2006
    Inventors: Weiwen Ying, David James, Shijie Zhang, Teresa Przewloka, Junghyun Chae, Dinesh Chimmanamada, Chi-Wan Lee, Elena Kostik, Howard Ng, Kevin Foley, Zhenjian Du, James Barsoum
  • Synthesis of organic nanotubes and synthesis of ultrathin nanowires using same as templates
    Patent number: 6762331
    Abstract: The present invention discloses a method for synthesizing a calix[4]hydroquinone organic nanotube and a method for synthesizing an ultrathin, stable nanowire using said organic nanotube as a template.
    Type: Grant
    Filed: February 13, 2002
    Date of Patent: July 13, 2004
    Assignee: Postech Foundation
    Inventors: Byung Hee Hong, Chi-Wan Lee, Kwang Soo Kim
  • Synthesis of organic nanotubes and synthesis of ultrathin nanowires using same as templates
    Publication number: 20020185368
    Abstract: The present invention discloses a method for synthesizing a calix[4]hydroquinone organic nanotube and a method for synthesizing an ultrathin, stable nanowire using said organic nanotube as a template.
    Type: Application
    Filed: February 13, 2002
    Publication date: December 12, 2002
    Inventors: Byung Hee Hong, Chi-Wan Lee, Kwang Soo Kim