Abstract: A computational engineering modelling tool having a point generation module arranged to read geometry data representing a domain to be modelled. The point generation module also generates point data for the domain having multiple boundary points located on a boundary of the domain and multiple further points spaced from the boundary within the domain. A point mutation module processes the point generation module output and generates automatically a plurality of alternative point data definitions for the domain in which the location of at least one point differs between each of the alternative point definitions. A blocking module discretizes the domain by creating multiple geometric blocks over the domain using a computational geometric operator wherein each point represents a vertex of at least one block. The blocking module outputs a discretized computational model of the domain and the tool scores the model according to a geometric attribute of the blocks.

Abstract: A method and system are proposed to obtain quantitative data about the shape of a biological structure, and especially a heart ventricle. A set of three-dimensional input meshes are generated from MRI data. They represent the shape of a ventricle at successive times. The input meshes are used to generate a set of three-dimensional morphed meshes which have the same number of vertices as each other, and have respective shapes which are the shapes of corresponding ones of the input meshes. Then, for each of the times, shape analysis is performed to obtain a curvedness value at each of a plurality of corresponding locations in the morphed meshes. The curvedness value may be used to obtain a curvedness rate at each of the locations, indicative of the rate of change of curvedness with time at each of the locations.

Abstract: Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R3 is a monocyclic heteroaryl group, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for modulating the activity of lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia-d for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract: A method of coating a calcium carbonate film. In one aspect, the method includes preparing a calcium aqueous solution by adding a calcium-containing material to distilled water; forming a calcium carbonate film on a surface of the calcium aqueous solution by leaving the calcium aqueous solution; placing the calcium carbonate film on a substrate; and forming a calcium carbonate coating film by leaving the calcium carbonate film on the substrate.

Abstract: An apparatus comprising a light source (110), one or more light guides (104), and a light diffuser (102) having an integration chamber (114) surrounded by one or more light diffusive areas (108). The one or more light diffusive areas are configured with one or more first openings as one or more ingress areas (112) to receive light from the light source and one or more second openings as one or more egress areas (106) to provide light to the one or more light guides. For illuminating visual indicators with uniform light.

Abstract: A method of separating a secondary alcohol compound from a primary alcohol compound using selective acylation is provided.

Abstract: An image sensor of a camera configured with a diffraction grating is used to capture a diffraction image of an image rendering surface of a display device, for example, while a target image is being rendered on the image rendering surface of the display device. The diffraction image of the image rendering surface of the display device is analyzed to obtain measurements of native display capabilities of the display device. Display capability data is transmitted to a display management module for the display device. At least a portion of the display capability data is generated from the measurements of native display capabilities of the display device that are obtained from analyzing the diffraction image of the image rendering surface of the display device.

Abstract: A method of separating a secondary alcohol compound from a primary alcohol compound using selective acylation is provided.

Abstract: Compounds of Formulae Ia, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract: Methods and apparatus are provided for encoding and decoding image data using localized gamut definitions. The localized gamut definitions may be defined based on gamut characteristics of the image data. A gamut transform is applied to the image data wherein color coordinates specified by the image data are mapped to corresponding color coordinates in the localized gamut definition. Use of localized gamut definitions may facilitate image data compression of increased color depth specification of image data.

Abstract: Techniques for driving a dual modulation display include generating backlight drive signals to drive individually-controllable illumination sources. The illumination sources emit first light onto a light conversion layer. The light conversion layer converts the first light into second light. The light conversion layer can include quantum dots or phosphor materials. Modulation drive signals are generated to determine transmission of the second light through individual subpixels of the display. These modulation drive signals can be adjusted based on one or more light field simulations. The light field simulations can include: (i) a color shift for a pixel based on a point spread function of the illumination sources; (ii) binning difference of individual illumination sources; (iii) temperature dependence of display components on performance; or (iv) combinations thereof.

Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

Abstract: Perceptually correct noises simulating a variety of noise patterns or textures may be applied to stereo image pairs each of which comprises a left eye (LE) image and a right eye (RE) image that represent a 3D image. LE and RE images may or may not be noise removed. Depth information of pixels in the LE and RE images may be computed from, or received with, the LE and RE images. Desired noise patterns are modulated onto the 3D image or scene so that the desired noise patterns are perceived to be part of 3D objects or image details, taking into account where the 3D objects or image details are on a z-axis perpendicular to an image rendering screen on which the LE and RE images are rendered.

Abstract: Chromaticity of light output by a light-emitting diode, such as a light-emitting diode (LED), is adjusted while maintaining a brightness of the illumination source substantially constant by adjusting a drive schema for the illumination source. A driver for LEDs or other light-emitting diodes provides for varying a drive schema to adjust chromaticity of driven LEDs.

Abstract: Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R3 is a monocyclic heteroaryl group, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for modulating the activity of lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia-d for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract: Compounds of Formula I, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract: Approximation errors commonly occur when color transformation values stored in color look-up tables are interpolated to produce color display drive signals, since the stored transformation values typically correspond to non-linear functions. Such errors can be reduced by applying a pre-indexing function to the transformation values before they are stored in the look-up table, and by applying the same function to values extracted from the table during look-up operations. Alternatively, such errors can be reduced by providing one or more additional look-up tables to achieve higher order (i.e. more accurate) interpolation results that are achievable by interpolation of values stored in a single look-up table.

Abstract: Fused pyrimidines of formula (I): wherein R1-R3, A and n have any of the values described in the specification; and pharmaceutically acceptable salts thereof; have activity as inhibitors of PI3K and may thus be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders. Processes for synthesizing the compounds are also described.

Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.