Patents by Inventor Chi-Yu Gregory Lee

Chi-Yu Gregory Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RP215 chimeric antigen receptor construct and methods of making and using same
    Patent number: 11447562
    Abstract: A chimeric antigen receptor (CAR) having an antigen binding domain capable of binding to CA215. The antigen binding domain can have a binding affinity and specificity similar to the RP215 antibody. Methods of making and using such CARs are provided. The CARs can be used to treat cancer.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: September 20, 2022
    Inventor: Chi-Yu Gregory Lee
  • RP215 CHIMERIC ANTIGEN RECEPTOR CONSTRUCT AND METHODS OF MAKING AND USING SAME
    Publication number: 20190345257
    Abstract: A chimeric antigen receptor (CAR) having an antigen binding domain capable of binding to CA215. The antigen binding domain can have a binding affinity and specificity similar to the RP215 antibody. Methods of making and using such CARs are provided. The CARs can be used to treat cancer.
    Type: Application
    Filed: December 22, 2017
    Publication date: November 14, 2019
    Inventor: Chi-Yu Gregory LEE
  • CARBOHYDRATE HAPTEN-BASED ANTI-CANCER VACCINES AND ANTIBODY DRUGS
    Publication number: 20130195873
    Abstract: Immunogenic compositions that contain haptens consisting of carbohydrate moieties are useful to induce an immune response to provide antibodies to epitopes contained in CA215 and also to elicit an immune response to cancers expressing these epitopes.
    Type: Application
    Filed: July 14, 2011
    Publication date: August 1, 2013
    Applicant: Vancouver Biotech LTD.
    Inventor: Chi-Yu Gregory Lee
  • Monoclonal antibodies against gonadotropin-releasing hormone receptor
    Patent number: 8361793
    Abstract: Monoclonal antibodies against gonadotropin releasing hormone (GnRH) receptor induce cellular apoptosis of various cancer cells expressing this surface receptor. The monoclonal antibodies and their humanized forms, or fragments thereof, can serve as anti-cancer agents for the treatment of cancer in humans, and can function as analogs of GnRH to affect regulation of reproductive functions or fertility in humans.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: January 29, 2013
    Assignee: Vancouver Biotech Ltd.
    Inventor: Chi-Yu Gregory Lee
  • MONOCLONAL ANTIBODIES AGAINST GONADOTROPIN-RELEASING HORMONE RECEPTOR
    Publication number: 20120266264
    Abstract: Monoclonal antibodies against gonadotropin releasing hormone (GnRH) receptor induce cellular apoptosis of various cancer cells expressing this surface receptor. The monoclonal antibodies and their humanized forms, or fragments thereof, can serve as anti-cancer agents for the treatment of cancer in humans, and can function as analogs of GnRH to affect regulation of reproductive functions or fertility in humans.
    Type: Application
    Filed: April 13, 2012
    Publication date: October 18, 2012
    Applicant: Vancouver Biotech LTD.
    Inventor: Chi-Yu Gregory LEE
  • CARBOHYDRATE-CONTAINING PAN CANCER MARKER
    Publication number: 20120177636
    Abstract: The effective epitope of CA215, a known cancer marker and antigen, has been demonstrated to include a carbohydrate moiety of defined composition and to be non-reactive with anti-human IgG, IgA and IgM, although CA215 is an immunoglobulin heavy chain-like molecule. The defined epitope may be used to prepare immunogenic compositions for treatment and prevention of cancers in humans and may be optimized as to protocol and formulation in animal model systems. Improved protocols for diagnosis and treatment are also described.
    Type: Application
    Filed: March 22, 2012
    Publication date: July 12, 2012
    Applicant: VANCOUVER BIOTECH LTD.
    Inventor: Chi-Yu Gregory LEE
  • Monoclonal antibodies against gonadotropin-releasing hormone receptor
    Patent number: 8163283
    Abstract: Monoclonal antibodies against gonadotropin releasing hormone (GnRH) receptor induce cellular apoptosis of various cancer cells expressing this surface receptor. The monoclonal antibodies and their humanized forms, or fragments thereof, can serve as anti-cancer agents for the treatment of cancer in humans, and can function as analogs of GnRH to affect regulation of reproductive functions or fertility in humans.
    Type: Grant
    Filed: September 3, 2010
    Date of Patent: April 24, 2012
    Assignee: Vancouver Biotech Ltd.
    Inventor: Chi-Yu Gregory Lee
  • Carbohydrate-containing pan cancer marker
    Patent number: 8143373
    Abstract: The effective epitope of CA215, a known cancer marker and antigen, has been demonstrated to include a carbohydrate moiety of defined composition and to be non-reactive with anti-human IgG, IgA and IgM, although CA215 is an immunoglobulin heavy chain-like molecule. The defined epitope may be used to prepare immunogenic compositions for treatment and prevention of cancers in humans and may be optimized as to protocol and formulation in animal model systems. Improved protocols for diagnosis and treatment are also described.
    Type: Grant
    Filed: May 14, 2008
    Date of Patent: March 27, 2012
    Assignee: Vancouver Biotech Ltd.
    Inventor: Chi-Yu Gregory Lee
  • MONOCLONAL ANTIBODIES AGAINST GONADOTROPIN-RELEASING HORMONE RECEPTOR
    Publication number: 20110113497
    Abstract: Monoclonal antibodies against gonadotropin releasing hormone (GnRH) receptor induce cellular apoptosis of various cancer cells expressing this surface receptor. The monoclonal antibodies and their humanized forms, or fragments thereof, can serve as anti-cancer agents for the treatment of cancer in humans, and can function as analogs of GnRH to affect regulation of reproductive functions or fertility in humans.
    Type: Application
    Filed: September 3, 2010
    Publication date: May 12, 2011
    Inventor: Chi-Yu Gregory LEE
  • CARBOHYDRATE-CONTAINING PAN CANCER MARKER
    Publication number: 20110033445
    Abstract: The effective epitope of CA215, a known cancer marker and antigen, has been demonstrated to include a carbohydrate moiety of defined composition and to be non-reactive with anti-human IgG, IgA and IgM, although CA215 is an immunoglobulin heavy chain-like molecule. The defined epitope may be used to prepare immunogenic compositions for treatment and prevention of cancers in humans and may be optimized as to protocol and formulation in animal model systems. Improved protocols for diagnosis and treatment are also described.
    Type: Application
    Filed: May 14, 2008
    Publication date: February 10, 2011
    Inventor: Chi-Yu Gregory Lee
  • Monoclonal antibodies against an antigen associated with ovarian cervical and other tumors
    Patent number: 5650291
    Abstract: Monoclonal antibodies immunoreactive with tumor-associated antigen, CA 215 which is present on an ovarian tumor cell line, fragments of those antibodies (either radiolabeled, bound to a toxin, or unlabeled), and the cell line which secretes them are described.
    Type: Grant
    Filed: August 8, 1994
    Date of Patent: July 22, 1997
    Assignee: The University of British Columbia
    Inventor: Chi-Yu Gregory Lee