Abstract: Provided herein are methods of assaying a methylated DNA-binding protein comprising contacting methylated DNA-binding proteins with labeled oligonucleotides, obtaining sample partitions for oligonucleotides with different methylation states, and quantifying the labeled oligonucleotides in the partitions.

Abstract: A clock device is provided for generating a real-time clock. The clock device includes a frequency generator, a measuring module, a setting module and a timing module. The frequency generator generates a frequency signal. The measuring module is coupled to the frequency generator for measuring the frequency signal and generating a measuring frequency value. The setting module is coupled to the measuring module for generating an error setting value corresponding to the measuring frequency value. The timing module is coupled to the frequency generator and the setting module for compensating the frequency signal according to the error setting value and generating the real-time clock.

Abstract: The invention provides a circuit for generating a drive voltage. The circuit of the invention includes a first current generating unit coupled between a voltage source and a ground for generating a first input current. A comparing unit having a first input terminal coupled to the first current generating unit and a second input terminal coupled to an output terminal thereof. The comparing unit is used for comparing the first input current with a second input current and generating an output voltage. A second current generating unit is coupled between the output terminal and the second input terminal of the comparing unit for generating the second input current. An adjusting unit is coupled to the second input terminal of the comparing unit, the second current generating unit and the ground for adjusting the second input current. The voltage level of the output voltage is controlled by the adjusting unit.

Abstract: A clock device is provided for generating a real-time clock. The clock device includes a frequency generator, a measuring module, a setting module and a timing module. The frequency generator generates a frequency signal. The measuring module is coupled to the frequency generator for measuring the frequency signal and generating a measuring frequency value. The setting module is coupled to the measuring module for generating an error setting value corresponding to the measuring frequency value. The timing module is coupled to the frequency generator and the setting module for compensating the frequency signal according to the error setting value and generating the real-time clock.