Patents by Inventor Chia-Cheng Shaw

Chia-Cheng Shaw has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing 4-borono-L-phenylalanine
    Patent number: 8765997
    Abstract: Provided is a process for preparing 4-borono-L-phenylalanine, which has steps of: reacting N-protected (S)-4-halophenylalanine of formula (I), a boronating agent and an organolithium to obtain a reaction mixture, wherein the reaction mixture comprises N-protected (S)-4-boronophenylalanine of formula (II) and the R group represents a protecting group; isolating the N-protected (S)-4-boronophenylalanine from the reaction mixture; deprotecting the R group of the N-protected (S)-4-boronophenylalanine to obtain L-BPA.
    Type: Grant
    Filed: June 5, 2013
    Date of Patent: July 1, 2014
    Assignee: Taiwan Biotech Co., Ltd.
    Inventors: Chia-Cheng Shaw, Kuen-Wang Sheu, Shu-Fen Huang
  • PROCESS FOR PREPARING 4-BORONO-L-PHENYLALANINE
    Publication number: 20130331602
    Abstract: Provided is a process for preparing 4-borono-L-phenylalanine, which has steps of: reacting N-protected (S)-4-halophenylalanine of formula (I), a boronating agent and an organolithium to obtain a reaction mixture, wherein the reaction mixture comprises N-protected (S)-4-boronophenylalanine of formula (II) and the R group represents a protecting group; isolating the N-protected (S)-4-boronophenylalanine from the reaction mixture; deprotecting the R group of the N-protected (S)-4-boronophenylalanine to obtain L-BPA.
    Type: Application
    Filed: June 5, 2013
    Publication date: December 12, 2013
    Inventors: Chia-Cheng Shaw, Kuen-Wang Sheu, Shu-Fen Huang
  • COMPOUND FOR PREPARING 4-(10B)BORONO-L-PHENYLALANINE
    Publication number: 20130331599
    Abstract: Provided is a compound of the following formula (I) for preparing 4-(10B)borono-L-phenylalnine: wherein R group represents a protecting group and is selected from the group consisting of: tert-butoxycarbonyl (Boc) group, trityl (Trt) group, 3,5-dimethoxyphenylisopropoxycarbonyl(Ddz) group, 2-(4-Biphenyl)isopropoxycarbonyl (Bpoc) group, and 2-nitrophenylsulfenyl (Nps) group, and the compound has a 10B purity higher than or equal to 98% and an enantiomeric excess higher than or equal to 99%.
    Type: Application
    Filed: June 5, 2013
    Publication date: December 12, 2013
    Inventors: Chia-Cheng Shaw, Kuen-Wang Sheu, Shu-Fen Huang
  • Indolylalkylamine metabolites as 5-hydroxytryptamine-6 ligands
    Patent number: 7498327
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
    Type: Grant
    Filed: June 22, 2005
    Date of Patent: March 3, 2009
    Assignee: Wyeth
    Inventors: Youchu Wang, Chia-Cheng Shaw, Ronald Charles Bernotas, Chung-Chiee Paul Wang, Ping Cai, Zhi Wang
  • Purification of rapamycin
    Patent number: 7384953
    Abstract: Purified rapamycin and a chemical process for obtaining the purified rapamycin are described.
    Type: Grant
    Filed: February 22, 2006
    Date of Patent: June 10, 2008
    Assignee: Wyeth
    Inventors: Chia-Cheng Shaw, Warren Chew, Bogdan Kazimierz Wilk
  • Chromane and chromene derivatives and uses thereof
    Publication number: 20080039639
    Abstract: Methods of preparing compounds of formula I or pharmaceutically acceptable salts thereof are provided: wherein each of R1, R2, R3, R4, x, m, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.
    Type: Application
    Filed: April 18, 2007
    Publication date: February 14, 2008
    Applicant: Wyeth
    Inventors: Alexander Gontcharov, Antonia Nikitenko, Panolil Raveendranath, Chia-Cheng Shaw, Bogdan Wilk, Dahui Zhou
  • Method of preparing 4-halogenated quinoline intermediates
    Publication number: 20070281932
    Abstract: This invention is directed to methods of preparing compounds of formula (I): comprising the step of reacting a compound of formula (II): with a reagent of formula POX3 and silica gel at a temperature greater than about 75° C., and wherein substitutions at X, PG, A, G, R1 and R4 are set forth in the specification.
    Type: Application
    Filed: May 23, 2007
    Publication date: December 6, 2007
    Applicant: WYETH
    Inventors: Caroline Bernier, Chia-Cheng Shaw
  • Recovery of CCI-779 from mother liquors
    Patent number: 7288647
    Abstract: The invention provides a process for recovering CCI-779 from mother liquors.
    Type: Grant
    Filed: February 22, 2006
    Date of Patent: October 30, 2007
    Assignee: Wyeth
    Inventors: Chia-Cheng Shaw, Warren Chew, Bogdan Kazimierz Wilk, Genevieve Fortier
  • Proline CCI-779, production of and uses therefor, and two-step enzymatic synthesis of proline CCI-779 and CCI-779
    Patent number: 7202256
    Abstract: Methods for the synthesis of CCI-779 and proline-CCI-779 are described, including a method involving lipase-catalyzed acetylation of 42-hydroxy of rapamycin with a vinyl ester of 2,2-bis(hydroxymethyl) propionic acid in an organic solvent followed by deprotection. Also provided are products containing proline-CCI-779 and uses thereof.
    Type: Grant
    Filed: April 12, 2005
    Date of Patent: April 10, 2007
    Assignee: Wyeth
    Inventors: Jianxin Gu, Mark E. Ruppen, Panolil Raveendranath, Warren Chew, Chia-Cheng Shaw
  • Regioselective synthesis of CCI-779
    Patent number: 7153957
    Abstract: A method for regioselective synthesis of CCl-779 based on boronate chemistry is provided. Also provided are novel intermediates useful in this method.
    Type: Grant
    Filed: July 30, 2004
    Date of Patent: December 26, 2006
    Assignee: Wyeth
    Inventors: Warren Chew, Chia-Cheng Shaw
  • Recovery of CCI-779 from mother liquors
    Publication number: 20060199253
    Abstract: The invention provides a process for recovering CCI-779 from mother liquors.
    Type: Application
    Filed: February 22, 2006
    Publication date: September 7, 2006
    Applicant: Wyeth
    Inventors: Chia-Cheng Shaw, Warren Chew, Bogdan Wilk, Genevieve Fortier
  • Purification of rapamycin
    Publication number: 20060199954
    Abstract: Purified rapamycin and a chemical process for obtaining the purified rapamycin are described.
    Type: Application
    Filed: February 22, 2006
    Publication date: September 7, 2006
    Applicant: Wyeth
    Inventors: Chia-Cheng Shaw, Warren Chew, Bogdan Wilk
  • Asymmetric synthesis of substituted dihydrobenzofurans
    Publication number: 20060111438
    Abstract: The present invention concerns production of a compound of the formula or a pharmaceutically acceptable salt thereof by a process which utilizes the cyclization of a compound of the formula: where Ar, Y, R1, Ry, R2, and m are as defined herein.
    Type: Application
    Filed: October 21, 2005
    Publication date: May 25, 2006
    Applicant: Wyeth
    Inventors: Alexander Gontcharov, Gulnaz Khafizova, John Potoski, Qing Yu, Chia-Cheng Shaw, Gary Stack, Dahui Zhou
  • Indolylalkylamine metabolites as 5-hydroxytryptamine-6 ligands
    Publication number: 20060003945
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: June 22, 2005
    Publication date: January 5, 2006
    Applicant: Wyeth
    Inventors: Youchu Wang, Chia-Cheng Shaw, Ronald Bernotas, Chung-Chiee Wang, Ping Cai, Zhi Wang
  • Proline CCI-779, production of and uses therefor, and two-step enzymatic synthesis of proline CCI-779 and CCI-779
    Publication number: 20050234086
    Abstract: Methods for the synthesis of CCI-779 and proline-CCI-779 are described, including a method involving lipase-catalyzed acetylation of 42-hydroxy of rapamycin with a vinyl ester of 2,2-bis(hydroxymethyl) propionic acid in an organic solvent followed by deprotection. Also provided are products containing proline-CCI-779 and uses thereof.
    Type: Application
    Filed: April 12, 2005
    Publication date: October 20, 2005
    Applicant: Wyeth
    Inventors: Jianxin Gu, Mark Ruppen, Panolil Raveendranath, Warren Chew, Chia-Cheng Shaw
  • Regioselective synthesis of CCI-779
    Publication number: 20050033046
    Abstract: A method for regioselective synthesis of CCl-779 based on boronate chemistry is provided. Also provided are novel intermediates useful in this method.
    Type: Application
    Filed: July 30, 2004
    Publication date: February 10, 2005
    Inventors: Warren Chew, Chia-Cheng Shaw
  • Regioselective synthesis of rapamycin derivatives
    Publication number: 20010039338
    Abstract: This invention provides a regioselective process for preparing a 42-ester or ether of rapamycin, and 31-silyl ether intermediates.
    Type: Application
    Filed: June 7, 2001
    Publication date: November 8, 2001
    Applicant: American Home Products Corporation
    Inventors: Chia-Cheng Shaw, John Sellstedt, Razzak Noureldin, Gloria K. Cheal, Genevieve Fortier
  • Regioselective synthesis of rapamycin derivatives
    Patent number: 6277983
    Abstract: This invention provides a regioselective process for preparing a 42-ester or ether of rapamycin, and 31-silyl ether intermediates.
    Type: Grant
    Filed: September 27, 2000
    Date of Patent: August 21, 2001
    Assignee: American Home Products Corporation
    Inventors: Chia-Cheng Shaw, John Sellstedt, Razzak Noureldin, Gloria K. Cheal, Genevieve Fortier
  • Production of certain 2-phenylalkylthio-and 2-phenylalkylsulfinyl imidazo[4,]pyridines
    Patent number: 5001238
    Abstract: This invention relates to the process for the preparation of certain 2-phenylalkylthio- and phenylalkylsulfinyl-imidazo[4,5-c]pyridines useful for the treatment of osteoporosis.
    Type: Grant
    Filed: June 19, 1990
    Date of Patent: March 19, 1991
    Assignee: American Home Products Corporation
    Inventors: Chia-Cheng Shaw, Razzak Noureldin, Gregory Gavin
  • Production of substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids
    Patent number: 4897493
    Abstract: Process for the production of substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids having useful analgesic and anti-inflammatory activity.
    Type: Grant
    Filed: January 31, 1989
    Date of Patent: January 30, 1990
    Assignee: American Home Products Corporation
    Inventors: Chia-Cheng Shaw, Karel Pelz