Patents by Inventor Chia-Chin Sheu

Chia-Chin Sheu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11510902
    Abstract: A method for preventing or treating a non-alcoholic fatty liver disease in a subject who is at risk of suffering from the non-alcoholic fatty liver disease or suffers from the non-alcoholic fatty liver disease, by administering to the subject a composition comprising a therapeutically effective amount of Antrodins.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: November 29, 2022
    Assignee: SIMPSON BIOTECH CO., LTD.
    Inventors: Chia-Chin Sheu, Tse-Kai Fu
  • Publication number: 20200390745
    Abstract: A method for preventing or treating a non-alcoholic fatty liver disease in a subject who is at risk of suffering from the non-alcoholic fatty liver disease or suffers from the non-alcoholic fatty liver disease, by administering to the subject a composition comprising a therapeutically effective amount of Antrodins.
    Type: Application
    Filed: June 12, 2020
    Publication date: December 17, 2020
    Applicant: Simpson Biotech Co., Ltd.
    Inventors: Chia-Chin Sheu, Tse-Kai Fu
  • Patent number: 9950028
    Abstract: The present invention relates to a method for preventing or treating virus and protozoa infection in a subject in need thereof comprising: orally administering to said subject an effective amount of a composition comprising a complex consisting of a starch binding protein (SBP)-tagged immunostimulatory protein and a SBP-binding matrix, wherein the immunostimulatory protein is from Ganoderma species. The present invention also relates to a method for inducing interferon-gamma production in a subject in need thereof comprising: orally administering to said subject an effective amount of a composition comprising a complex consisting of a starch binding protein (SBP)-tagged immunostimulatory protein and a SBP-binding matrix, wherein the immunostimulatory protein is from Ganoderma species.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: April 24, 2018
    Assignee: SIMPSON BIOTECH CO., LTD
    Inventors: Chia-Chin Sheu, Chang-Yeu Liu
  • Patent number: 9713605
    Abstract: The present invention relates to a method of preventing or ameliorating the symptoms of arthritis or preventing or ameliorating cartilage destruction or chondrocyte death in a subject suffered from arthritis, comprising administrating the subject an effective amount of an active component selected from a compound, a mixture, and a mycelium prepared from Antrodia cinnamomea.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: July 25, 2017
    Assignee: Simpson Biotech Co., Ltd.
    Inventors: Wei-Tso Chia, Chia-Chin Sheu
  • Publication number: 20170112808
    Abstract: The present invention relates to novel uses of compounds from Antrodia cinnamomea mycelia and mixtures comprising the compounds. The novel uses comprise whitening skin, combating skin ageing, reducing scar formation, inducing or enhancing liver regeneration, or treating fibrosis or a fibrosis-associated disorder in a subject in need thereof. The compounds have the formula and preferably are selected from 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]furan-2,5-dione, 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrol-2,5-dione, 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrol-1-ol-2,5-dione, 3R*,4S*-1-hydroxy-3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]pyrrolidine-2,5-dione, and 3R*,4R*-1-hydroxy-3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]pyrrolidine-2,5-dione.
    Type: Application
    Filed: January 5, 2017
    Publication date: April 27, 2017
    Applicant: Simpson Biotech Co., Ltd.
    Inventors: Kai-Wen Huang, Chia-Chin Sheu
  • Publication number: 20170065672
    Abstract: The present invention relates to a method for preventing or treating virus and protozoa infection in a subject in need thereof comprising: orally administering to said subject an effective amount of a composition comprising a complex consisting of a starch binding protein (SBP)-tagged immunostimulatory protein and a SBP-binding matrix, wherein the immunostimulatory protein is from Ganoderma species. The present invention also relates to a method for inducing interferon-gamma production in a subject in need thereof comprising: orally administering to said subject an effective amount of a composition comprising a complex consisting of a starch binding protein (SBP)-tagged immunostimulatory protein and a SBP-binding matrix, wherein the immunostimulatory protein is from Ganoderma species.
    Type: Application
    Filed: March 4, 2015
    Publication date: March 9, 2017
    Inventors: Chia-Chin Sheu, Chang-Yeu Liu
  • Patent number: 9572760
    Abstract: The present invention relates to novel uses of compounds from Antrodia cinnamomea mycelia and mixtures comprising the compounds. The novel uses comprise whitening skin, combating skin ageing, reducing scar formation, inducing or enhancing liver regeneration, or treating fibrosis or a fibrosis-associated disorder in a subject in need thereof. The compounds have the formula and preferably are selected from 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]furan-2,5-dione, 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrol-2,5-dione, 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrol-1-ol-2,5-dione, 3R*,4S*-1-hydroxy-3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]pyrrolidine-2,5-dione, and 3R*,4R*-1-hydroxy-3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]pyrrolidine-2,5-dione.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: February 21, 2017
    Assignee: Simpson Biotech Co., Ltd.
    Inventors: Kai-Wen Huang, Chia-Chin Sheu
  • Patent number: 9328370
    Abstract: The present invention relates to a recombinant protein comprising SEQ ID NO: 1 and a bacteria recognizing lectin. The present invention also relates to uses of the recombinant protein comprising detecting pathogens, removing endotoxins, determining the presence of an endotoxin or endotoxin-like material, and determining the presence of pathogen-associated molecular pattern (PAMP) comprising rhamnose-rhamnose (Rha-Rha), rhamnose-N-acetyl-mannosamine (Rha-ManNAc), N-acetyl-mannosamine-rhamnose (ManNAc-Rha), rhamnose-galatose (Rha-Gal), or galatose-rhamnose (Gal-Rha) in a sample, and use as a medicament, a disinfectant, a decontaminant, a surfactant or a diagnostic means.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: May 3, 2016
    Assignee: SIMPSON BIOTECH CO., LTD.
    Inventors: Margaret Dah-Tsyr Chang, Chia-Chin Sheu
  • Patent number: 9115083
    Abstract: The present invention relates to compounds from Antrodia cinnamomea. The present invention also relates to a composition and a method for treating or prophylaxis of hepatitis C virus (HCV) or human immunodeficiency virus (HIV) infection.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: August 25, 2015
    Assignee: SIMPSON BIOTECH CO., LTD.
    Inventors: Masao Hattori, Ali El-Halawany, Megumi Mizuno, Chia-Chin Sheu
  • Publication number: 20150110726
    Abstract: The present invention relates to novel uses of compounds from Antrodia cinnamomea mycelia and mixtures comprising the compounds. The novel uses comprise whitening skin, combating skin ageing, reducing scar formation, inducing or enhancing liver regeneration, or treating fibrosis or a fibrosis-associated disorder in a subject in need thereof. The compounds have the formula and preferably are selected from 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]furan-2,5-dione, 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrol-2,5-dione, 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrol-1-ol-2,5-dione, 3R*,4S*-1-hydroxy-3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]pyrrolidine-2,5-dione, and 3R*,4R*-1-hydroxy-3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]pyrrolidine-2,5-dione.
    Type: Application
    Filed: October 22, 2014
    Publication date: April 23, 2015
    Applicant: Simpson Biotech Co., Ltd.
    Inventors: Kai-Wen Huang, Chia-Chin Sheu
  • Patent number: 8986955
    Abstract: The present invention provides a method and a system for increasing thermal stability of a target protein comprising fusing a starch binding protein (SBP) with the target protein to form a SBP-tagged recombinant protein and combining the SBP-tagged recombinant protein with a SBP-binding matrix. The present invention also provides a method for retaining an activity of a target protein in aquatic environment comprising fusing a starch binding protein (SBP) with the target protein to form a SBP-tagged recombinant protein and combining the SBP-tagged recombinant protein with a SBP-binding matrix.
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: March 24, 2015
    Assignee: Simpson Biotech Co., Ltd.
    Inventors: Margaret Dah-Tsyr Chang, Chia-Chin Sheu
  • Publication number: 20140343250
    Abstract: The present invention relates to a recombinant protein comprising SEQ ID NO: 1 and a bacteria recognizing lectin. The present invention also relates to uses of the recombinant protein comprising detecting pathogens, removing endotoxins, determining the presence of an endotoxin or endotoxin-like material, and determining the presence of pathogen-associated molecular pattern (PAMP) comprising rhamnose-rhamnose (Rha-Rha), rhamnose-N-acetyl-mannosamine (Rha-ManNAc), N-acetyl-mannosamine-rhamnose (ManNAc-Rha), rhamnose-galatose (Rha-Gal), or galatose-rhamnose (Gal-Rha) in a sample, and use as a medicament, a disinfectant, a decontaminant, a surfactant or a diagnostic means.
    Type: Application
    Filed: May 13, 2014
    Publication date: November 20, 2014
    Applicant: SIMPSON BIOTECH CO., LTD.
    Inventors: Margaret Dah-Tsyr Chang, Chia-Chin Sheu
  • Patent number: 8772329
    Abstract: The present invention relates to compounds from mycelium of Antrodia cinnamomea. The present invention also relates to a composition and a method for treating or prophylaxis of hepatitis C virus (HCV) infection.
    Type: Grant
    Filed: January 28, 2008
    Date of Patent: July 8, 2014
    Assignee: Simpson Biotech Co., Ltd.
    Inventors: Chia-Chin Sheu, Masao Hattori
  • Publication number: 20140179753
    Abstract: The present invention relates to compounds from Antrodia cinnamomea. The present invention also relates to a composition and a method for treating or prophylaxis of hepatitis C virus (HCV) or human immunodeficiency virus (HIV) infection.
    Type: Application
    Filed: March 5, 2014
    Publication date: June 26, 2014
    Applicant: Simpson Biotech Co., Ltd.
    Inventors: Masao HATTORI, Ali EL-HALAWANY, Megumi MIZUNO, Chia-Chin SHEU
  • Patent number: 8703968
    Abstract: The present invention relates to compounds from Antrodia cinnamomea. The present invention also relates to a composition and a method for treating or prophylaxis of hepatitis C virus (HCV) or human immunodeficiency virus (HIV) infection.
    Type: Grant
    Filed: October 17, 2012
    Date of Patent: April 22, 2014
    Assignee: Simpson Biotech Co., Ltd.
    Inventors: Masao Hattori, Ali El-Halawany, Megumi Mizuno, Chia-Chin Sheu
  • Patent number: 8648113
    Abstract: The present invention relates to a compound derived from mycelium of Antrodia camphorata. The present invention also relates to the composition or mycelium comprising the compounds of the invention. The composition of the invention decreases systolic blood pressure and increases high density lipoprotein.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: February 11, 2014
    Assignee: Simpson Biotech Co., Ltd.
    Inventors: Masao Hattori, Chia-Chin Sheu
  • Patent number: 8551695
    Abstract: The present invention provides a method for identifying starch binding sites of starch binding domain in CBM family. The CBM family is consisting of CBM20, CBM21, CBM25, CBM26, CBM34, and CBM41. The method further comprises predicting starch binding sites of starch binding domain in CBM family using the identified starch binding sites of starch binding domain with same topology.
    Type: Grant
    Filed: January 23, 2012
    Date of Patent: October 8, 2013
    Assignee: Simpson Biotech Co., Ltd.
    Inventors: Margaret Dah-Tsyr Chang, Ping-Chiang Lyu, Yuh-Ju Sun, Chia-Chin Sheu
  • Publication number: 20130129772
    Abstract: The present invention relates to a method of preventing or ameliorating the symptoms of arthritis or preventing or ameliorating cartilage destruction or chondrocyte death in a subject suffered from arthritis, comprising administrating the subject an effective amount of an active component selected from a compound, a mixture, and a mycelium prepared from Antrodia cinnamomea.
    Type: Application
    Filed: November 19, 2012
    Publication date: May 23, 2013
    Applicant: SIMPSON BIOTECH CO., LTD.
    Inventors: Wei-Tso Chia, Chia-Chin Sheu
  • Publication number: 20120225492
    Abstract: The present invention provides a method for identifying starch binding sites of starch binding domain in CBM family. The CBM family is consisting of CBM20, CBM21, CBM25, CBM26, CBM34, and CBM41. The method further comprises predicting starch binding sites of starch binding domain in CBM family using the identified starch binding sites of starch binding domain with same topology.
    Type: Application
    Filed: January 23, 2012
    Publication date: September 6, 2012
    Applicant: SIMPSON BIOTECH CO., LTD.
    Inventors: Margaret Dah-Tsyr Chang, Ping-Chiang Lyu, Yuh-Ju Sun, Chia-Chin Sheu
  • Patent number: 8101792
    Abstract: The present invention relates to novel compounds from Antrodia cinnamomea and their use.
    Type: Grant
    Filed: September 17, 2007
    Date of Patent: January 24, 2012
    Assignee: Simpson Biotech Co., Ltd.
    Inventors: Chia-Chin Sheu, Masao Hattori