Patents by Inventor Chia-Chin Sheu
Chia-Chin Sheu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11510902Abstract: A method for preventing or treating a non-alcoholic fatty liver disease in a subject who is at risk of suffering from the non-alcoholic fatty liver disease or suffers from the non-alcoholic fatty liver disease, by administering to the subject a composition comprising a therapeutically effective amount of Antrodins.Type: GrantFiled: June 12, 2020Date of Patent: November 29, 2022Assignee: SIMPSON BIOTECH CO., LTD.Inventors: Chia-Chin Sheu, Tse-Kai Fu
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Publication number: 20200390745Abstract: A method for preventing or treating a non-alcoholic fatty liver disease in a subject who is at risk of suffering from the non-alcoholic fatty liver disease or suffers from the non-alcoholic fatty liver disease, by administering to the subject a composition comprising a therapeutically effective amount of Antrodins.Type: ApplicationFiled: June 12, 2020Publication date: December 17, 2020Applicant: Simpson Biotech Co., Ltd.Inventors: Chia-Chin Sheu, Tse-Kai Fu
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Patent number: 9950028Abstract: The present invention relates to a method for preventing or treating virus and protozoa infection in a subject in need thereof comprising: orally administering to said subject an effective amount of a composition comprising a complex consisting of a starch binding protein (SBP)-tagged immunostimulatory protein and a SBP-binding matrix, wherein the immunostimulatory protein is from Ganoderma species. The present invention also relates to a method for inducing interferon-gamma production in a subject in need thereof comprising: orally administering to said subject an effective amount of a composition comprising a complex consisting of a starch binding protein (SBP)-tagged immunostimulatory protein and a SBP-binding matrix, wherein the immunostimulatory protein is from Ganoderma species.Type: GrantFiled: March 4, 2015Date of Patent: April 24, 2018Assignee: SIMPSON BIOTECH CO., LTDInventors: Chia-Chin Sheu, Chang-Yeu Liu
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Patent number: 9713605Abstract: The present invention relates to a method of preventing or ameliorating the symptoms of arthritis or preventing or ameliorating cartilage destruction or chondrocyte death in a subject suffered from arthritis, comprising administrating the subject an effective amount of an active component selected from a compound, a mixture, and a mycelium prepared from Antrodia cinnamomea.Type: GrantFiled: November 19, 2012Date of Patent: July 25, 2017Assignee: Simpson Biotech Co., Ltd.Inventors: Wei-Tso Chia, Chia-Chin Sheu
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Publication number: 20170112808Abstract: The present invention relates to novel uses of compounds from Antrodia cinnamomea mycelia and mixtures comprising the compounds. The novel uses comprise whitening skin, combating skin ageing, reducing scar formation, inducing or enhancing liver regeneration, or treating fibrosis or a fibrosis-associated disorder in a subject in need thereof. The compounds have the formula and preferably are selected from 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]furan-2,5-dione, 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrol-2,5-dione, 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrol-1-ol-2,5-dione, 3R*,4S*-1-hydroxy-3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]pyrrolidine-2,5-dione, and 3R*,4R*-1-hydroxy-3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]pyrrolidine-2,5-dione.Type: ApplicationFiled: January 5, 2017Publication date: April 27, 2017Applicant: Simpson Biotech Co., Ltd.Inventors: Kai-Wen Huang, Chia-Chin Sheu
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Publication number: 20170065672Abstract: The present invention relates to a method for preventing or treating virus and protozoa infection in a subject in need thereof comprising: orally administering to said subject an effective amount of a composition comprising a complex consisting of a starch binding protein (SBP)-tagged immunostimulatory protein and a SBP-binding matrix, wherein the immunostimulatory protein is from Ganoderma species. The present invention also relates to a method for inducing interferon-gamma production in a subject in need thereof comprising: orally administering to said subject an effective amount of a composition comprising a complex consisting of a starch binding protein (SBP)-tagged immunostimulatory protein and a SBP-binding matrix, wherein the immunostimulatory protein is from Ganoderma species.Type: ApplicationFiled: March 4, 2015Publication date: March 9, 2017Inventors: Chia-Chin Sheu, Chang-Yeu Liu
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Patent number: 9572760Abstract: The present invention relates to novel uses of compounds from Antrodia cinnamomea mycelia and mixtures comprising the compounds. The novel uses comprise whitening skin, combating skin ageing, reducing scar formation, inducing or enhancing liver regeneration, or treating fibrosis or a fibrosis-associated disorder in a subject in need thereof. The compounds have the formula and preferably are selected from 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]furan-2,5-dione, 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrol-2,5-dione, 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrol-1-ol-2,5-dione, 3R*,4S*-1-hydroxy-3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]pyrrolidine-2,5-dione, and 3R*,4R*-1-hydroxy-3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]pyrrolidine-2,5-dione.Type: GrantFiled: October 22, 2014Date of Patent: February 21, 2017Assignee: Simpson Biotech Co., Ltd.Inventors: Kai-Wen Huang, Chia-Chin Sheu
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Patent number: 9328370Abstract: The present invention relates to a recombinant protein comprising SEQ ID NO: 1 and a bacteria recognizing lectin. The present invention also relates to uses of the recombinant protein comprising detecting pathogens, removing endotoxins, determining the presence of an endotoxin or endotoxin-like material, and determining the presence of pathogen-associated molecular pattern (PAMP) comprising rhamnose-rhamnose (Rha-Rha), rhamnose-N-acetyl-mannosamine (Rha-ManNAc), N-acetyl-mannosamine-rhamnose (ManNAc-Rha), rhamnose-galatose (Rha-Gal), or galatose-rhamnose (Gal-Rha) in a sample, and use as a medicament, a disinfectant, a decontaminant, a surfactant or a diagnostic means.Type: GrantFiled: May 13, 2014Date of Patent: May 3, 2016Assignee: SIMPSON BIOTECH CO., LTD.Inventors: Margaret Dah-Tsyr Chang, Chia-Chin Sheu
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Patent number: 9115083Abstract: The present invention relates to compounds from Antrodia cinnamomea. The present invention also relates to a composition and a method for treating or prophylaxis of hepatitis C virus (HCV) or human immunodeficiency virus (HIV) infection.Type: GrantFiled: March 5, 2014Date of Patent: August 25, 2015Assignee: SIMPSON BIOTECH CO., LTD.Inventors: Masao Hattori, Ali El-Halawany, Megumi Mizuno, Chia-Chin Sheu
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Publication number: 20150110726Abstract: The present invention relates to novel uses of compounds from Antrodia cinnamomea mycelia and mixtures comprising the compounds. The novel uses comprise whitening skin, combating skin ageing, reducing scar formation, inducing or enhancing liver regeneration, or treating fibrosis or a fibrosis-associated disorder in a subject in need thereof. The compounds have the formula and preferably are selected from 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]furan-2,5-dione, 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrol-2,5-dione, 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrol-1-ol-2,5-dione, 3R*,4S*-1-hydroxy-3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]pyrrolidine-2,5-dione, and 3R*,4R*-1-hydroxy-3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]pyrrolidine-2,5-dione.Type: ApplicationFiled: October 22, 2014Publication date: April 23, 2015Applicant: Simpson Biotech Co., Ltd.Inventors: Kai-Wen Huang, Chia-Chin Sheu
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Patent number: 8986955Abstract: The present invention provides a method and a system for increasing thermal stability of a target protein comprising fusing a starch binding protein (SBP) with the target protein to form a SBP-tagged recombinant protein and combining the SBP-tagged recombinant protein with a SBP-binding matrix. The present invention also provides a method for retaining an activity of a target protein in aquatic environment comprising fusing a starch binding protein (SBP) with the target protein to form a SBP-tagged recombinant protein and combining the SBP-tagged recombinant protein with a SBP-binding matrix.Type: GrantFiled: October 8, 2012Date of Patent: March 24, 2015Assignee: Simpson Biotech Co., Ltd.Inventors: Margaret Dah-Tsyr Chang, Chia-Chin Sheu
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Publication number: 20140343250Abstract: The present invention relates to a recombinant protein comprising SEQ ID NO: 1 and a bacteria recognizing lectin. The present invention also relates to uses of the recombinant protein comprising detecting pathogens, removing endotoxins, determining the presence of an endotoxin or endotoxin-like material, and determining the presence of pathogen-associated molecular pattern (PAMP) comprising rhamnose-rhamnose (Rha-Rha), rhamnose-N-acetyl-mannosamine (Rha-ManNAc), N-acetyl-mannosamine-rhamnose (ManNAc-Rha), rhamnose-galatose (Rha-Gal), or galatose-rhamnose (Gal-Rha) in a sample, and use as a medicament, a disinfectant, a decontaminant, a surfactant or a diagnostic means.Type: ApplicationFiled: May 13, 2014Publication date: November 20, 2014Applicant: SIMPSON BIOTECH CO., LTD.Inventors: Margaret Dah-Tsyr Chang, Chia-Chin Sheu
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Patent number: 8772329Abstract: The present invention relates to compounds from mycelium of Antrodia cinnamomea. The present invention also relates to a composition and a method for treating or prophylaxis of hepatitis C virus (HCV) infection.Type: GrantFiled: January 28, 2008Date of Patent: July 8, 2014Assignee: Simpson Biotech Co., Ltd.Inventors: Chia-Chin Sheu, Masao Hattori
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Publication number: 20140179753Abstract: The present invention relates to compounds from Antrodia cinnamomea. The present invention also relates to a composition and a method for treating or prophylaxis of hepatitis C virus (HCV) or human immunodeficiency virus (HIV) infection.Type: ApplicationFiled: March 5, 2014Publication date: June 26, 2014Applicant: Simpson Biotech Co., Ltd.Inventors: Masao HATTORI, Ali EL-HALAWANY, Megumi MIZUNO, Chia-Chin SHEU
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Patent number: 8703968Abstract: The present invention relates to compounds from Antrodia cinnamomea. The present invention also relates to a composition and a method for treating or prophylaxis of hepatitis C virus (HCV) or human immunodeficiency virus (HIV) infection.Type: GrantFiled: October 17, 2012Date of Patent: April 22, 2014Assignee: Simpson Biotech Co., Ltd.Inventors: Masao Hattori, Ali El-Halawany, Megumi Mizuno, Chia-Chin Sheu
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Patent number: 8648113Abstract: The present invention relates to a compound derived from mycelium of Antrodia camphorata. The present invention also relates to the composition or mycelium comprising the compounds of the invention. The composition of the invention decreases systolic blood pressure and increases high density lipoprotein.Type: GrantFiled: October 12, 2012Date of Patent: February 11, 2014Assignee: Simpson Biotech Co., Ltd.Inventors: Masao Hattori, Chia-Chin Sheu
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Patent number: 8551695Abstract: The present invention provides a method for identifying starch binding sites of starch binding domain in CBM family. The CBM family is consisting of CBM20, CBM21, CBM25, CBM26, CBM34, and CBM41. The method further comprises predicting starch binding sites of starch binding domain in CBM family using the identified starch binding sites of starch binding domain with same topology.Type: GrantFiled: January 23, 2012Date of Patent: October 8, 2013Assignee: Simpson Biotech Co., Ltd.Inventors: Margaret Dah-Tsyr Chang, Ping-Chiang Lyu, Yuh-Ju Sun, Chia-Chin Sheu
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Publication number: 20130129772Abstract: The present invention relates to a method of preventing or ameliorating the symptoms of arthritis or preventing or ameliorating cartilage destruction or chondrocyte death in a subject suffered from arthritis, comprising administrating the subject an effective amount of an active component selected from a compound, a mixture, and a mycelium prepared from Antrodia cinnamomea.Type: ApplicationFiled: November 19, 2012Publication date: May 23, 2013Applicant: SIMPSON BIOTECH CO., LTD.Inventors: Wei-Tso Chia, Chia-Chin Sheu
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Publication number: 20120225492Abstract: The present invention provides a method for identifying starch binding sites of starch binding domain in CBM family. The CBM family is consisting of CBM20, CBM21, CBM25, CBM26, CBM34, and CBM41. The method further comprises predicting starch binding sites of starch binding domain in CBM family using the identified starch binding sites of starch binding domain with same topology.Type: ApplicationFiled: January 23, 2012Publication date: September 6, 2012Applicant: SIMPSON BIOTECH CO., LTD.Inventors: Margaret Dah-Tsyr Chang, Ping-Chiang Lyu, Yuh-Ju Sun, Chia-Chin Sheu
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Patent number: 8101792Abstract: The present invention relates to novel compounds from Antrodia cinnamomea and their use.Type: GrantFiled: September 17, 2007Date of Patent: January 24, 2012Assignee: Simpson Biotech Co., Ltd.Inventors: Chia-Chin Sheu, Masao Hattori