Patents by Inventor Chia-Hsien Hsu

Chia-Hsien Hsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250067954
    Abstract: An optical member driving mechanism is provided. The optical member driving mechanism includes a first movable portion used for connecting an optical element, a fixed portion, a first driving assembly used for driving the first movable portion to rotate relative to the fixed portion, and a guiding assembly having a first intermediate element. The first movable portion is movable relative to the fixed portion. The guiding assembly is used for applying a first stabilized force to the first movable portion for making the first intermediate element be in contact with the first movable portion or the fixed portion. The first movable portion is rotatable relative to the fixed portion.
    Type: Application
    Filed: November 8, 2024
    Publication date: February 27, 2025
    Inventors: Chih-Wei WENG, Chao-Chang HU, Yueh-Lin LEE, Chen-Hsien FAN, Chien-Yu KAO, Chia-Ching HSU, Sung-Mao TSAI, Sin-Jhong SONG
  • Patent number: 12219780
    Abstract: A memory device and method of making the same, the memory device including bit lines disposed on a substrate; memory cells disposed on the bit lines; a first dielectric layer disposed on the substrate, surrounding the bit lines and the memory cells; a second dielectric layer disposed on the first dielectric layer; thin film transistors (TFTs) embedded in the second dielectric layer and configured to selectively provide electric power to corresponding memory cells, the TFTs comprising drain lines disposed on the memory cells, source lines disposed on the first dielectric layer, and selector layers electrically connected to the source lines and the drain lines; and word lines disposed on the second dielectric layer and electrically connected to the TFTs.
    Type: Grant
    Filed: June 30, 2023
    Date of Patent: February 4, 2025
    Assignee: Taiwan Semiconductor Manufacturing Company Limited
    Inventors: Yen-Chung Ho, Hui-Hsien Wei, Mauricio Manfrini, Chia-Jung Yu, Yong-Jie Wu, Ken-Ichi Goto, Pin-Cheng Hsu
  • Patent number: 12219778
    Abstract: A memory structure includes: first and second word lines; a high-k dielectric layer disposed on the first and second word lines; a channel layer disposed on the high-k dielectric layer and comprising a semiconductor material; first and second source electrodes electrically contacting the channel layer; a first drain electrode disposed on the channel layer between the first and second source electrodes; a memory cell electrically connected to the first drain electrode; and a bit line electrically connected to the memory cell.
    Type: Grant
    Filed: April 14, 2021
    Date of Patent: February 4, 2025
    Assignee: Taiwan Semiconductor Manufacturing Company Limited
    Inventors: Yong-Jie Wu, Yen-Chung Ho, Hui-Hsien Wei, Chia-Jung Yu, Pin-Cheng Hsu, Mauricio Manfrini, Chung-Te Lin
  • Patent number: 12204163
    Abstract: An optical system affixed to an electronic apparatus is provided, including a first optical module, a second optical module, and a third optical module. The first optical module is configured to adjust the moving direction of a first light from a first moving direction to a second moving direction, wherein the first moving direction is not parallel to the second moving direction. The second optical module is configured to receive the first light moving in the second moving direction. The first light reaches the third optical module via the first optical module and the second optical module in sequence. The third optical module includes a first photoelectric converter configured to transform the first light into a first image signal.
    Type: Grant
    Filed: February 5, 2024
    Date of Patent: January 21, 2025
    Assignee: TDK TAIWAN CORP.
    Inventors: Chao-Chang Hu, Chih-Wei Weng, Chia-Che Wu, Chien-Yu Kao, Hsiao-Hsin Hu, He-Ling Chang, Chao-Hsi Wang, Chen-Hsien Fan, Che-Wei Chang, Mao-Gen Jian, Sung-Mao Tsai, Wei-Jhe Shen, Yung-Ping Yang, Sin-Hong Lin, Tzu-Yu Chang, Sin-Jhong Song, Shang-Yu Hsu, Meng-Ting Lin, Shih-Wei Hung, Yu-Huai Liao, Mao-Kuo Hsu, Hsueh-Ju Lu, Ching-Chieh Huang, Chih-Wen Chiang, Yu-Chiao Lo, Ying-Jen Wang, Shu-Shan Chen, Che-Hsiang Chiu
  • Publication number: 20250019129
    Abstract: A sealing structure includes a box body and a cover body. The box body includes a plurality of side walls respectively including a plurality of outer and inner portions, an annular groove formed on the inner portions, and an annular protrusion portion. Each outer portion has a level difference with the corresponding inner portion. Any two adjacent ones of the side walls form a corner portion. An outer surface of each corner portion forms a sharp corner. The annular groove is arc-shaped at a position corresponding to each corner portion. Each corner portion includes a hollowed-out area. The cover body includes a main body in a polygonal shape with sharp corners, an annular protrusion portion protruding from the main body, and an annular groove. The annular protrusion portions extend into the annular grooves, so that the cover body is sealedly joined to the box body.
    Type: Application
    Filed: July 11, 2024
    Publication date: January 16, 2025
    Applicant: Lite-On Technology Corporation
    Inventors: Yun Hao Fan, Chia Tsang Hsu, Wan-Chen Chen, Ying Hsien Chen, Shuo-Jen Shieh
  • Publication number: 20240384321
    Abstract: The invention relates to a microfluidic chip for motion-based dynamic phenotypic antibiotic drug testing. The microfluidic chip designed with 1000 observation-chambers which physically-traps ˜200 individual bacterium using oil-liquid cutting under certain operational conditions. The oil infusion provides separation of monodispersed pico-chamber volumes within 20 sec. The utility of the microfluidic chip was successfully demonstrated by multi-parametric motion-analysis of ampicillin and gentamicin treated E. coli 25922GFP™ for 21 hours of incubation at 37° C. The large-scanned images are utilized for the enumeration of viable, unculturable, filamentous and dead bacteria isolated in the device. The 2D motion-analysis are found useful for the rapid antibiotic susceptibility testing (AST) within 4 hours. The present invention can also be useful for phenotypic AST of clinical isolates and shed light on the early diagnosis and treatment of antibiotic resistant bacterial diseases in the future.
    Type: Application
    Filed: May 17, 2024
    Publication date: November 21, 2024
    Inventors: Chia-Hsien HSU, Didem RODOPLU SOLOVCHUK
  • Patent number: 12011712
    Abstract: This invention provides a high-efficient single-cell collection method using a specially designed collection well and collection pipet tip for particle/cell collection from the collection well. The structures of the collection well and pipet tip eliminate fluidic dead volume in the collection, resulting in all (or most) of the particles/cells can be brought into the collection pipette tip with the flow. The advantages of this invention in cell manipulation include high cell collection efficiency, low cell damage and easy operation procedure.
    Type: Grant
    Filed: November 10, 2021
    Date of Patent: June 18, 2024
    Assignee: NATIONAL HEALTH RESEARCH INSTITUTES
    Inventors: Chia-Hsien Hsu, Chuan-Feng Yeh
  • Publication number: 20220143595
    Abstract: This invention provides a high-efficient single-cell collection method using a specially designed collection well and collection pipet tip for particle/cell collection from the collection well. The structures of the collection well and pipet tip eliminate fluidic dead volume in the collection, resulting in all (or most) of the particles/cells can be brought into the collection pipette tip with the flow. The advantages of this invention in cell manipulation include high cell collection efficiency, low cell damage and easy operation procedure.
    Type: Application
    Filed: November 10, 2021
    Publication date: May 12, 2022
    Inventors: Chia-Hsien HSU, Chuan-Feng YEH
  • Patent number: 10946381
    Abstract: A hydrodynamic shuttling chip device comprising an array of single-cell trapping units is disclosed. Each unit comprises: (a) an incoming channel with a cell capture site; (b) a cell culture chamber located posterior to the cell capture site, having a receiving site spaced apart from the cell capture site at a distance of g; (c) a trapping channel located between the cell capture site and the receiving site; (d) a chamber channel located posterior to and in fluidic connection with the cell culture chamber; and (e) a by-pass channel, located lateral to the incoming channel, chamber and chamber channel and having a first end and a second end opposite to the first end, the first end branching out from the incoming channel immediately prior to the cell capture site and the second end joining the chamber channel. A method of capturing single cells of more than one type is also disclosed.
    Type: Grant
    Filed: August 13, 2016
    Date of Patent: March 16, 2021
    Assignee: NATIONAL HEALTH RESEARCH INSTITUTES
    Inventor: Chia-Hsien Hsu
  • Publication number: 20190072465
    Abstract: Methods and systems capturing particles suspended in a fluid flowed through a micro-channel, can include flowing the fluid including the particles to be captured through a micro-channel and past a groove defined in a surface of a wall of the micro-channel such that flowing the fluid past the groove forms microvortices in the fluid; contacting at least some of the particles against an adherent disposed on one or more of walls of the microchannel after the microvortices form in the fluid; and capturing at least some of the particles contacting the adherent.
    Type: Application
    Filed: November 5, 2018
    Publication date: March 7, 2019
    Inventors: Mehmet Toner, Shannon Stott, Chia-Hsien Hsu
  • Patent number: 10126218
    Abstract: Methods and systems capturing particles suspended in a fluid flowed through a micro-channel, can include flowing the fluid including the particles to be captured through a micro-channel and past a groove defined in a surface of a wall of the micro-channel such that flowing the fluid past the groove forms microvortices in the fluid; contacting at least some of the particles against an adherent disposed on one or more of walls of the microchannel after the microvortices form in the fluid; and capturing at least some of the particles contacting the adherent.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: November 13, 2018
    Assignee: The General Hospital Corporation
    Inventors: Mehmet Toner, Shannon Stott, Chia-Hsien Hsu
  • Publication number: 20180243742
    Abstract: A hydrodynamic shuttling chip device comprising an array of single-cell trapping units is disclosed. Each unit comprises: (a) an incoming channel with a capture site; (b) a large chamber located posterior to the capture site, having a receiving structure spaced apart from the capture site at a distance of g; (c) a trapping channel located between the capture site and the receiving, site; (d) a chamber channel located posterior to and in fluidic connection with the large chamber; and (e) a by-pass channel, located lateral to the incoming channel, large chamber and chamber channel and having a first end and a second end opposite to the first end, the first end branching out from the incoming channel immediately prior to the capture site and the second end joining the chamber channel. A method of capturing single cells of more than one type is also disclosed.
    Type: Application
    Filed: August 13, 2016
    Publication date: August 30, 2018
    Inventor: Chia-Hsien HSU
  • Patent number: 10000732
    Abstract: A microfluidic dual-well device is disclosed. The device comprises: (a) a first substrate having a first end, a second end, and a culture microwell forming portion; (b) a plurality of culture microwells; (c) a second substrate having a first end, a second end, and a capture microwell forming portion, the two ends of the second substrate being respectively bounded to the two ends of the first substrate; (d) a plurality of capture microwells; (e) a microfluidic channel; (f) a microfluidic inlet port; and (g) a microfluidic outlet port; wherein the microfluidic channel is in fluidic connections with the culture microwells, the capture microwells, and the inlet and outlet ports. Methods of capturing and transferring a single cell or a single cell colony for culture, and method of transferring a target cell from a polydimethylsiloxane (PDMS) structure of culture microwells to a culture plate for culture are also disclosed.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: June 19, 2018
    Assignee: NATIONAL HEALTH RESEARCH INSTITUTES
    Inventors: Chia-Hsien Hsu, Ching-Hui Lin, Hao-Chen Chang, Ing-Ming Chiu
  • Publication number: 20170145363
    Abstract: A microfluidic dual-well device is disclosed. The device comprises: (a) a first substrate having a first end, a second end, and a culture microwell forming portion; (b) a plurality of culture microwells; (c) a second substrate having a first end, a second end, and a capture microwell forming portion, the two ends of the second substrate being respectively bounded to the two ends of the first substrate; (d) a plurality of capture microwells; (e) a microfluidic channel; (f) a microfluidic inlet port; and (g) a microfluidic outlet port; wherein the microfluidic channel is in fluidic connections with the culture microwells, the capture microwells, and the inlet and outlet ports. Methods of capturing and transferring a single cell or a single cell colony for culture, and method of transferring a target cell from a polydimethylsiloxane (PDMS) structure of culture microwells to a culture plate for culture are also disclosed.
    Type: Application
    Filed: May 19, 2016
    Publication date: May 25, 2017
    Inventors: Chia-Hsien HSU, Ching-Hui LIN, Duane S. JUANG, Hao-Chen CHANG, Ing-Ming CHIU
  • Patent number: 9494500
    Abstract: A system and method thereof for collecting and concentrating a biologic substance of interest is provided. The biologic of interest obtained from a biologic sample present at an initial low concentration (or low number counts) can be captured and released through a collection device of the system to an intermediate second concentration, and further recovered through a concentration device of the system to a third concentration, thereby facilitating subsequent detection, characterization, enumeration, immunostaining, inspection, imaging, culturing, molecular analysis, and/or other assays.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: November 15, 2016
    Assignee: Academia Sinica
    Inventors: Ying-Chih Chang, Chia-Hsien Hsu
  • Publication number: 20150377753
    Abstract: Methods and systems capturing particles suspended in a fluid flowed through a micro-channel, can include flowing the fluid including the particles to be captured through a micro-channel and past a groove defined in a surface of a wall of the micro-channel such that flowing the fluid past the groove forms microvortices in the fluid; contacting at least some of the particles against an adherent disposed on one or more of walls of the microchannel after the microvortices form in the fluid; and capturing at least some of the particles contacting the adherent.
    Type: Application
    Filed: September 2, 2015
    Publication date: December 31, 2015
    Inventors: Mehmet Toner, Shannon Stott, Chia-Hsien Hsu
  • Patent number: 9128091
    Abstract: Methods and systems capturing particles suspended in a fluid flowed through a micro-channel, can include flowing the fluid including the particles to be captured through a micro-channel and past a groove defined in a surface of a wall of the micro-channel such that flowing the fluid past the groove forms microvortices in the fluid; contacting at least some of the particles against an adherent disposed on one or more of walls of the microchannel after the microvortices form in the fluid; and capturing at least some of the particles contacting the adherent.
    Type: Grant
    Filed: September 25, 2009
    Date of Patent: September 8, 2015
    Assignee: The General Hospital Corporation
    Inventors: Mehmet Toner, Shannon Stott, Chia-Hsien Hsu
  • Patent number: 9034636
    Abstract: A microfluidic hanging drop chip is disclosed. Also disclosed are methods for culturing cells and forming cell aggregates in hanging drops.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: May 19, 2015
    Assignees: NATIONAL HEALTH RESEACH INSTITUTES, NATIONAL TSING HUA UNIVERSITY
    Inventors: Chia-Hsien Hsu, Chih-Chen Chen
  • Publication number: 20140120537
    Abstract: A system and method thereof for collecting and concentrating a biologic substance of interest is provided. The biologic of interest obtained from a biologic sample present at an initial low concentration (or low number counts) can be captured and released through a collection device of the system to an intermediate second concentration, and further recovered through a concentration device of the system to a third concentration, thereby facilitating subsequent detection, characterization, enumeration, immunostaining, inspection, imaging, culturing, molecular analysis, and/or other assays.
    Type: Application
    Filed: October 28, 2013
    Publication date: May 1, 2014
    Inventors: Ying-Chih Chang, Chia-Hsien Hsu
  • Publication number: 20130084634
    Abstract: A microfluidic hanging drop chip is disclosed. Also disclosed are methods for culturing cells and forming cell aggregates in hanging drops.
    Type: Application
    Filed: September 26, 2012
    Publication date: April 4, 2013
    Applicants: NATIONAL TSING HUA UNIVERSITY, NATIONAL HEALTH RESEARCH INSTITUTES
    Inventors: Chia-Hsien Hsu, Chih-Chen Chen