Abstract: This invention discloses a peptide, which inhibits the interaction between of MZF-1 and Elk-1 and further inhibits cancers. Both myeloid zinc finger 1 (MZF-1) and Ets-like protein-1 (Elk-1) expressions correlate to PKC? expression in cancer cells. Furthermore, it is the interaction between the acidic domain of MZF-1 and the heparin-binding domain of Elk-1 which facilitated their heterodimeric complex formation before their binding to the PKC? promoter. Blocking the formation of the heterodimer changed Elk-1 nuclear localization, MZF-1 protein degradation, their DNA-binding activities, and subsequently the expression of PKC? in cancer cells. Thus, migration, tumorigenicity, and epithelial-mesenchymal transition potential of cancer cells decreased, suggesting that the Elk-1/MZF-1 heterodimer is considered as a mediator of PKC? in TNBC cell malignancy.

Abstract: An optical coupling device includes an optical coupling member, an optical-electrical converting module, and at least two optical fibers. The optical coupling member has a first under positioning portion. The optical-electrical converting module has a substrate, a base, an optical signal transmitter, and an optical signal receiver. The base is made of an insulating material and is provided on the substrate. The base has a receiving portion and a second under positioning portion to engage the first under positioning portion. The optical signal transmitter and the optical signal receiver are receiving in the receiving portion and face the first lens portion when the second under positioning portion engages the first under positioning portion. The optical fibers are beside the optical coupling member and face the second lens portion.

Abstract: An optical coupling device includes an optical coupling member, an optical-electrical converting module, and at least two optical fibers. The optical coupling member has a first under positioning portion. The optical-electrical converting module has a substrate, a base, an optical signal transmitter, and an optical signal receiver. The base is made of an insulating material and is provided on the substrate. The base has a receiving portion and a second under positioning portion to engage the first under positioning portion. The optical signal transmitter and the optical signal receiver are receiving in the receiving portion and face the first lens portion when the second under positioning portion engages the first under positioning portion. The optical fibers are beside the optical coupling member and face the second lens portion.