Patents by Inventor Chia-Lin J. Wang

Chia-Lin J. Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antiatherosclerosis agents for lipid-lowering and antiperoxidative activity
    Patent number: 5840991
    Abstract: The invention relates to novel compounds of formula (I) ##STR1## wherein R.sub.1 represents hydrogen, hydroxy or alkoxy;R.sub.2, R.sub.3, R.sub.4 and R.sub.5 may be hydrogen or alkyl; andn is 0,1 or 2;and the pharmaceutically acceptable salts thereof.The invention also relates to the processes for preparing the compounds of formula (I), and the pharmaceutical compositions containing them, and their use as a low density lipoprotein peroxidation inhibitors, anti-atherosclerotic agents and/or antihyperlipidemic agents.
    Type: Grant
    Filed: September 17, 1997
    Date of Patent: November 24, 1998
    Assignee: Development Center for Biotechnology
    Inventors: Feng-Wen Yeng, Shan-Shue Wang, Jaw-Yuh Chiu, Chin-Fen Lee, Chia-Lin J. Wang
  • Preparation of fluconazole and pharmaceutically acceptable salts thereof
    Patent number: 5710280
    Abstract: A process for preparing fluconazole, including the steps of (1) acylating 1,3-difluorobenzene (DFB) to obtain 2-chloro-2',4'-difluoroacetophenone (CAP); (2) alkylating 4-amino-4H-1,2,4-triazole (4-AT) with CAP to obtain 2-(1H-1,2,4-triazol-1-yl)-2',4'-difluoroacetophenone (TAAP) salt; (3) deaminating TAAP salt to obtain TAAP; and (4) reacting TAAP with 1,2,4-triazole to obtain fluconazole.
    Type: Grant
    Filed: July 9, 1996
    Date of Patent: January 20, 1998
    Assignee: Development Center for Biotechnology
    Inventors: Kae-Shyang Shih, Lie-Rong Chen, Ching-Wei Liu, Chia-Lin J. Wang
  • Method for resolving racemic compounds
    Patent number: 5504221
    Abstract: A method for resolving racemic dimethyl-4,4'-dimethoxy-5,6,5',6'-di(methylenedioxy)biphenyl-2,2'-dicarbox ylate ("DDB"), in which a chiral .alpha.-alkyl benzyl alcohol is used as the resolving agent. More specifically, racemic DDB is first hydrolyzed to form dicarboxylic acid, which is then reacted with chiral .alpha.-alkyl benzyl alcohol to form two chiral isomers. The chiral isomers, after separation either by chromatography or by recrystalli-zation, are respectively hydrogenated and esterified to form chiral DDB isomers.
    Type: Grant
    Filed: March 2, 1995
    Date of Patent: April 2, 1996
    Assignee: Development Center for Biotechnology
    Inventors: Feng-Wen Yeng, Jaw-Yuh Chiu, Chia-Lin J. Wang
  • Aminomethyl oxooxazolidinyl oxa or thia cycloalkylbenzene derivatives useful as antibacterial agents
    Patent number: 5039690
    Abstract: Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives, such as l-N-[3-(2,3-dihydro-oxa or thio-lH-inden-5-yl)-2-oxooxazolidin-5-ylmethyl]acetamide, possess useful antibacterial activity.
    Type: Grant
    Filed: March 15, 1990
    Date of Patent: August 13, 1991
    Assignee: Du Pont Merck Pharmaceutical Company
    Inventors: Chia-Lin J. Wang, Mark A. Wuonola
  • Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents
    Patent number: 5036092
    Abstract: Aminomethyl oxooxazolidinyl aza cycloalkylbenzene derivatives, such as l-N-[3-(2,3-dihydro-3-aza-1H-inden-5-yl)-2-oxooxazolidin-5-ylmethyl]acetam ide, possess useful antibacterial activity.
    Type: Grant
    Filed: March 15, 1990
    Date of Patent: July 30, 1991
    Assignee: Du Pont Merck Pharmaceutical
    Inventors: Chia-Lin J. Wang, Mark A. Wuonola
  • Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives useful as antibacterial agents
    Patent number: 5036093
    Abstract: Aminomethyl oxooxazolidinyl azacycloalkylbenzene derivatives, such as l-N-[3-(2,3-dihydro-3-aza-1H-inden-5-yl)-2-oxooxazolidin-5-ylmethyl]acetam ide, possess useful antibacterial activity.
    Type: Grant
    Filed: March 15, 1990
    Date of Patent: July 30, 1991
    Assignee: Du Pont Merck Pharmaceutical
    Inventors: Chia-Lin J. Wang, Mark A. Wuonola
  • Aminomethyl oxooxazolidinyl oxa or thia cycloalkylbenzene derivatives useful as antibacterial agents
    Patent number: 5032605
    Abstract: Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives, such as l-N-[3-(2,3-dihydro-oxa or thia-1H-inden-5-yl)-2-oxooxazolidin-5-ylmethyl]acetamide, possess useful antibacterial activity.
    Type: Grant
    Filed: March 15, 1990
    Date of Patent: July 16, 1991
    Assignee: Du Pont Merck Pharmaceutical Company
    Inventors: Chia-Lin J. Wang, Mark A. Wuonola
  • Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
    Patent number: 4985429
    Abstract: Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives, such as l-N-[3-(2,3-dihydro-1-oxo-1H-inden-5-yl)-2-oxooxazolidin-5-ylmethyl]acetam ide, possess useful antibacterial activity.
    Type: Grant
    Filed: March 15, 1990
    Date of Patent: January 15, 1991
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Chia-Lin J. Wang, Mark A. Wuonola
  • Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
    Patent number: 4965268
    Abstract: Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives, such as l-N-[3-(2,3-dihydro-1-oxo-1H-inden-5-yl)-2-oxooxazolidin-5-ylmethyl]acetam ide, possess useful antibacterial activity.
    Type: Grant
    Filed: March 15, 1990
    Date of Patent: October 23, 1990
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Chia-Lin J. Wang, Mark A. Wuonola
  • Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
    Patent number: 4921869
    Abstract: Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives, such as l-N-[3-(2,3-dihydro-1-oxo-1H-inden-5-yl)-2-oxooxazolidin-5-ylmethyl]acetam ide, possess useful antibacterial activity.
    Type: Grant
    Filed: August 19, 1988
    Date of Patent: May 1, 1990
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Chia-Lin J. Wang, Mark A. Wuonola
  • S-modified adenosyl-1,8-diamino-3-thiooctane derivatives
    Patent number: 4803272
    Abstract: S-Modified Adenosyl-1,8-Diamino-3-Thiooctane derivatives which are useful as interferon potentiators and polyamine biosynthesis inhibitors are disclosed.
    Type: Grant
    Filed: February 24, 1987
    Date of Patent: February 7, 1989
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: David L. Anton, Bruce D. Korant, Chia-Lin J. Wang
  • Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
    Patent number: 4801600
    Abstract: Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives, such as l-N-[3-(2,3-dihydro-1-oxo-1H-inden-5-yl)-2-oxooxazolidin-5-ylmethyl]acetam ide, possess useful antibacterial activity.
    Type: Grant
    Filed: October 9, 1987
    Date of Patent: January 31, 1989
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Chia-Lin J. Wang, Mark A. Wuonola
  • 8-Aza-13-thiaprostanoids and a method of use thereof as anti-ulcer agents
    Patent number: 4530933
    Abstract: Biologically active 8-aza-13-thiaprostanoids having the formula: ##STR1## wherein A is CH.dbd.CH (cis or trans), C.tbd.C, CH.sub.2 CH.sub.2, ##STR2## or CHOHCH.sub.2 ; R is H, C.sub.1 to C.sub.12 n-alkyl, branched chain alkyl, or cycloalkyl, or a physiologically acceptable metal or amine salt cation;R.sup.1 is H, CH.sub.3 or C.sub.2 H.sub.5 ;R.sup.2 is CH.sub.3 or CF.sub.3 ; andn is an integer from 4 to 9.
    Type: Grant
    Filed: December 27, 1982
    Date of Patent: July 23, 1985
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Chia-Lin J. Wang
  • Justicidin insecticidal and antiviral compounds
    Patent number: 4486445
    Abstract: A natural lignan of the 1-aryl-2-napthoic acid type and related compounds are disclosed. The compounds correspond to the formula ##STR1## and exhibit both insecticidal and antiviral activity.
    Type: Grant
    Filed: January 12, 1983
    Date of Patent: December 4, 1984
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Narayan G. Patel, Chia-Lin J. Wang
  • 6-Keto- and 6-hydroxy-8-azaprostanoids and anti-ulcer use thereof
    Patent number: 4456613
    Abstract: Biologically active 6-keto- and 6-hydroxy-8-azaprostanoids having the formula: ##STR1## wherein A is O or ##STR2## R is CO.sub.2 R.sup.4 or CH.sub.2 OH; R.sup.1 is H, CH.sub.3, or C.sub.2 H.sub.5 ;R.sup.2 is H, CH.sub.3, or F;R.sup.3 is CH.sub.3 or CF.sub.3 ;R.sup.4 is H, C.sub.1 to C.sub.12 n-alkyl, branched chain alkyl, or cycloalkyl, or a physiologically acceptable metal or amine salt cation; andn is an integer from 3 to 8.
    Type: Grant
    Filed: December 27, 1982
    Date of Patent: June 26, 1984
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Chia-Lin J. Wang