Abstract: The present disclosure relates to a method for inhibiting a binding of a SARS-CoV-2 spike protein of a SARS-CoV-2 to an angiotensin-converting enzyme 2 including contacting the SARS-CoV-2 with a sufficient concentration of disulfiram, a method for inhibiting an activity of a main protease (Mpro) of SARS-CoV-2 including contacting a SARS-CoV-2 with a sufficient concentration of disulfiram, and a method for inhibiting an activity of a papain-like protease (PLpro) of SARS-CoV-2 including contacting a SARS-CoV-2 with a sufficient concentration of disulfiram. A method for inhibiting a replication or an infection of a SARS-CoV-2 in a cell includes contacting the cell with a sufficient concentration of disulfiram and a medical composition for use in a treatment of an infection of SARS-CoV-2 including a therapeutically effective amount of disulfiram are also provided.

Abstract: The present disclosure relates to a method for preventing or inhibiting a synthesis of viral RNA of SARS-CoV-2 in a cell including contacting the cell with a sufficient concentration of tafenoquine, boceprevir or narlaprevir and a method for inhibiting an activity of a main protease (Mpro) of SARS-CoV-2 including contacting a SARS-CoV-2 with a sufficient concentration of tafenoquine, boceprevir or narlaprevir. A medical composition for use in a treatment of an infection of SARS-CoV-2 including a therapeutically effective amount of tafenoquine, boceprevir or narlaprevir is also provided.

Abstract: Pharmaceutical compositions containing a combination of anti-chondrogenesis agents are disclosed. Methods of reducing scleral chondrogensis, reducing one or more ocular chondrogenic proteins, reducing inflammation induced chondrogensis and treating myopia by administering an effective amount of one or more anti-chondrogensis agents are also provided. The pharmaceutical compositions are useful for treating myopia.

Abstract: Pharmaceutical compositions containing a combination of anti-chondrogenesis agents are disclosed. Methods of reducing scleral chondrogensis, reducing one or more ocular chondrogenic proteins, reducing inflammation induced chondrogensis and treating myopia by administering an effective amount of one or more anti-chondrogensis agents are also provided. The pharmaceutical compositions are useful for treating myopia.

Abstract: Pharmaceutical compositions containing a combination of anti-chondrogenesis agents are disclosed. Methods of reducing scleral chondrogenesis, reducing one or more ocular chondrogenic proteins, reducing inflammation induced chondrogenesis and treating myopia by administering an effective amount of one or more anti-chondrogenesis agents are also provided. The pharmaceutical compositions are useful for treating myopia.

Abstract: Pharmaceutical compositions containing a combination of anti-chondrogenesis agents are disclosed. Methods of reducing scleral chondrogenesis, reducing one or more ocular chondrogenic proteins, reducing inflammation induced chondrogenesis and treating myopia by administering an effective amount of one or more anti-chondrogenesis agents are also provided. The pharmaceutical compositions are useful for treating myopia.

Abstract: Pharmaceutical compositions containing a combination of anti-chondrogenesis agents are disclosed. Methods of reducing scleral chondrogensis, reducing one or more ocular chondrogenic proteins, reducing inflammation induced chondrogensis and treating myopia by administering an effective amount of one or more anti-chondrogensis agents are also provided. The pharmaceutical compositions are useful for treating myopia.

Abstract: A method is provided for securely delivering identity data units over a communications network to a client device. The method includes receiving a selection from a customer identifying a final zipped package to be unpacked. The final zipped package is unpacked to obtain a common package and a digital signature file signed by an entity generating identity data requested by the customer. The digital signature in the digital signature file is verified and the common package is unpacked to obtain a plurality of outer packages and an encrypted symmetric key. The symmetric key is decrypted with a private key associated with the customer and each of the outer packages is decrypted with the symmetric key to obtain a plurality of identity data units.

Abstract: A method and apparatus is provided for maintaining inventory levels of identity data to be provisioned in electronic devices. The method includes monitoring over a communications network inventory levels of identity data records stored on a plurality of identity data personalization servers that each provision electronic devices with an identity data record. Additionally, if the inventory level on at least one of the identity data personalization servers falls below a minimum specified level, a refill request is sent to an identity data management authority requesting that additional identity data records be uploaded to the identity data personalization server.

Abstract: A method and apparatus are provided for generating identity data to be provisioned in product devices that are a part of a project. The method includes establishing a template associated with each CA in a hierarchical chain of CAs having a root CA at a highest level in the chain and a signing CA at a lowest level in the chain. The template associated with the signing CA inherits mandatory attribute fields specified in the root CA and any intermediate CA in the hierarchical chain. The mandatory attribute fields are user-specifiable fields to be populated with PKI data. A configuration file is generated upon receipt of an order for digital certificates using PKI data provided by a user to populate the mandatory attribute fields of the template associated with the signing CA. The digital certificates requested in the order are generated using the PKI data in the configuration file.

Abstract: A method is provided for securely delivering identity data units over a communications network to a client device. The method includes receiving a selection from a customer identifying a final zipped package to be unpacked. The final zipped package is unpacked to obtain a common package and a digital signature file signed by an entity generating identity data requested by the customer. The digital signature in the digital signature file is verified and the common package is unpacked to obtain a plurality of outer packages and an encrypted symmetric key. The symmetric key is decrypted with a private key associated with the customer and each of the outer packages is decrypted with the symmetric key to obtain a plurality of identity data units.

Abstract: A method and apparatus is provided for establishing a process for provisioning a digital certificate service delivered by a PKI system. The method includes receiving a request for a digital certificate service and receiving data specifying a project that includes at least one product to be provisioned with a digital certificate. Data specifying an identification of an owner organization of the project and at least one participant organization participating in the project is also received. Attributes with which PKI data to be included in the digital certificates is to comply is received from the owner organization. Based on the received data and attributes, an account is established for each of the organizations associated with the project through which users associated with each of the organizations can respectively request digital certificates for the at least one product in accordance with the attributes received from the owner organization.

Abstract: A method and apparatus are provided for generating identity data to be provisioned in product devices that are a part of a project. The method includes establishing a template associated with each CA in a hierarchical chain of CAs having a root CA at a highest level in the chain and a signing CA at a lowest level in the chain. The template associated with the signing CA inherits mandatory attribute fields specified in the root CA and any intermediate CA in the hierarchical chain. The mandatory attribute fields are user-specifiable fields to be populated with PKI data. A configuration file is generated upon receipt of an order for digital certificates using PKI data provided by a user to populate the mandatory attribute fields of the template associated with the signing CA. The digital certificates requested in the order are generated using the PKI data in the configuration file.

Abstract: An iterative method and associated algorithm for performing image registration to map features in a first image to corresponding features in a second image in accordance with a transformation model. Upon convergence of a parameter vector associated with the model, a current bootstrap region includes and exceeds an initial bootstrap region that is initially established. During the iterations, the parameter vector is estimated by minimizing an objective function with respect to the parameter vector. Each iteration generates a next bootstrap region that minimally includes the current bootstrap region and may exceed the current bootstrap region. The model may change in successive iterations.

Abstract: An iterative method and associated algorithm for performing image registration to map features in a first image to corresponding features in a second image in accordance with a transformation model. Upon convergence of a parameter vector associated with the model, a current bootstrap region includes and exceeds an initial bootstrap region that is initially established. During the iterations, the parameter vector is estimated by minimizing an objective function with respect to the parameter vector. Each iteration generates a next bootstrap region that minimally includes the current bootstrap region and may exceed the current bootstrap region. The model may change in successive iterations.