Abstract: Provided herein are oligonucleotides, trimeric peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease in a subject in need thereof, comprising administering to the subject oligonucleotides, trimeric peptides, and peptide-oligonucleotide-conjugates described herein. A synthetic method provides for the generation of a library of cell-penetrating peptides conjugated to an antisense oligonucleotide, and a machine learning-based generator-predictor-optimizer loop for the generation of novel peptide sequences capable of enhanced delivery of oligonucleotide cargo from the library of conjugates.

Abstract: The disclosure provides an electronic device. The electronic device has a first touch area and a second touch area. The first touch module is disposed in the first touch area and includes multiple first touch electrodes. The second touch module is disposed in the second touch area and includes multiple second touch electrodes. Multiple display electrodes are disposed in the first touch area, but not disposed in the second touch area. The integrated chip is electrically connected to the first touch module and the second touch module, and is configured to process a first touch signal transmitted by at least one of the first touch electrodes and process a second touch signal transmitted by at least one of the second touch electrodes. The electronic device of the disclosure can effectively save the number of pads of chips and reduce the chip space.

Abstract: Antisense oligomers and antisense oligomer conjugates complementary to a selected target site in the human dystrophin gene to induce exon 53 skipping are described.

Abstract: Antisense oligomers and antisense oligomer conjugates complementary to a selected target site in the human dystrophin gene to induce exon 53 skipping are described.

Abstract: An endoscope decontamination sheath includes a terminal section for seeing therethrough for an image and a sleeve section connected to the terminal section for receiving an endoscope to insert therein. The terminal section is of a tubular configuration. The terminal section has a front end to which a lens is mounted and a rear end in which an insertion groove is formed. The sleeve section is of an elongated tubular configuration having a front end fit into the insertion groove of the terminal section. In medical treatment of endoscopy or intubation, the endoscope is inserted into and sleeved with the sleeve section, and the endoscope sleeved with the decontamination sheath is inserted into an endotracheal tube. The matched arrangement between the lens and a lens of the endoscope helps prevent image deterioration and thus making images clearer. The decontamination sheath, after use, can be disposed of to prevent cross infection.

Abstract: Analog and logic devices may coexist on a common integrated circuit chip, accommodating features with different pitches, linewidths, and pattern densities. Such differences in design and layout at various layers during manufacturing can cause process loading by contributing different amounts of reactants to surface chemical reactions. Such variation in the balance of chemical reactants can result in disparities in film thicknesses within the chip that can affect device performance. Embodiments of the present disclosure disclose a masking sequence that can alleviate process loading disparities during an undercut etch process adjacent to polysilicon structures.

Abstract: An endoscope decontamination sheath includes a terminal section for seeing therethrough for an image and a sleeve section connected to the terminal section for receiving an endoscope to insert therein. The terminal section is of a tubular configuration. The terminal section has a front end to which a lens is mounted and a rear end in which an insertion groove is formed. The sleeve section is of an elongated tubular configuration having a front end fit into the insertion groove of the terminal section. In medical treatment of endoscopy or intubation, the endoscope is inserted into and sleeved with the sleeve section, and the endoscope sleeved with the decontamination sheath is inserted into an endotracheal tube. The matched arrangement between the lens and a lens of the endoscope helps prevent image deterioration and thus making images clearer. The decontamination sheath, after use, can be disposed of to prevent cross infection.

Abstract: A method of sidelink communications by a plurality of user equipment (UE) without the control of a base station in a wireless communication system is disclosed. In one embodiment, the UE being a scheduler end is configured to allocate the resources for initial/repeated transmissions and ACK/NACK messages, and also transmit information regarding the allocated resources to both the UEs being a transmitter end and a receiver end. In one embodiment, retransmission is performed when none of the scheduler and transmitter ends has received the ACK message sent by the receiver end, so as to minimize redundant retransmission in consideration of transmission reliability. In one embodiment, retransmission is performed when at least one of the scheduler and transmitters end has received the NACK message sent by the receiver end before the retransmission timer has reached to zero, so as to minimize transmission latency.

Abstract: A method of sidelink communications by a plurality of user equipment (UE) without the control of a base station in a wireless communication system is disclosed. In one embodiment, the UE being a scheduler end is configured to allocate the resources for initial/repeated transmissions and ACK/NACK messages, and also transmit information regarding the allocated resources to both the UEs being a transmitter end and a receiver end. In one embodiment, retransmission is performed when none of the scheduler and transmitter ends has received the ACK message sent by the receiver end, so as to minimize redundant retransmission in consideration of transmission reliability. In one embodiment, retransmission is performed when at least one of the scheduler and transmitters end has received the NACK message sent by the receiver end before the retransmission timer has reached to zero, so as to minimize transmission latency.

Abstract: Antisense oligomers and antisense oligomer conjugates complementary to a selected target site in the human dystrophin gene to induce exon 53 skipping are described.

Abstract: Antisense oligomers, and antisense oligomer conjugates complementary to a selected target site in the human, dystrophin gene to induce exon 53 skipping are described.

Abstract: The disclosure relates to methods for nucleic acid purification, comprising (a) combining a sample comprising at least one nucleic acid with a binding buffer comprising at least one magnetic particle and having a pH ranging from about 4 to about 10 to form a solution; (b) incubating the sample with the binding buffer for a time period sufficient to reversibly bind the at least one nucleic acid to the at least one magnetic particle to form at least one modified magnetic particle, (c) separating the at least one modified magnetic particle from the solution, (d) washing the at least one modified magnetic particle with at least one wash buffer; and (e) combining the at least one modified magnetic particle with an elution buffer Kits comprising these buffers and magnetic particles are also disclosed herein.

Abstract: The disclosure relates to methods for nucleic acid purification, comprising (a) combining a sample comprising at least one nucleic acid with a binding buffer comprising at least one magnetic particle and having a pH ranging from about 4 to about 10 to form a solution; (b) incubating the sample with the binding buffer for a time period sufficient to reversibly bind the at least one nucleic acid to the at least one magnetic particle to form at least one modified magnetic particle, (c) separating the at least one modified magnetic particle from the solution, (d) washing the at least one modified magnetic particle with at least one wash buffer; and (e) combining the at least one modified magnetic particle with an elution buffer Kits comprising these buffers and magnetic particles are also disclosed herein.

Abstract: The disclosure relates to methods for nucleic acid purification, comprising (a) combining a sample comprising at least one nucleic acid with a binding buffer comprising at least one magnetic particle and having a pH ranging from about 4 to about 10 to form a solution; (b) incubating the sample with the binding buffer for a time period sufficient to reversibly bind the at least one nucleic acid to the at least one magnetic particle to form at least one modified magnetic particle, (c) separating the at least one modified magnetic particle from the solution, (d) washing the at least one modified magnetic particle with at least one wash buffer; and (e) combining the at least one modified magnetic particle with an elution buffer Kits comprising these buffers and magnetic particles are also disclosed herein.

Abstract: Provided herein are systems, kits, and methods for nucleic acid purification from blood samples. In particular, provided herein are reagents, e.g. dissolving buffer comprising sarcosine, and methods of using such reagents, for high yield purification of nucleic acids from blood samples, including dried blood samples. Also claimed is a system for purifying nucleic acids from whole blood samples comprising a lysis buffer comprising guanidine and disodium hydrogen phosphate. Magnetic particles are suggested as solid support for capturing the nucleic acids.

Abstract: The disclosure relates to methods for nucleic acid purification, comprising (a) combining a sample comprising at least one nucleic acid with a suspension buffer to form a suspension, (b) combining the suspension with a lysis buffer to form a lysate, (c) combining the lysate with a binding buffer to form a solution; (d) combining the solution with at least one magnetic particle to form a combined solution comprising at least one modified magnetic particle reversibly bound to the at least one nucleic acid, (e) separating the at least one modified magnetic particle from the combined solution, (f) washing the at least one modified magnetic particle with a first wash buffer and a second wash buffer, and (g) combining the at least one modified magnetic particle with an elution buffer. Kits comprising these buffers and magnetic particles are also disclosed herein.

Abstract: The disclosure relates to methods for nucleic acid purification, comprising (a) combining a sample comprising at least one nucleic acid with a binding buffer comprising at least one magnetic particle and having a pH ranging from about 4 to about 10 to form a solution; (b) incubating the sample with the binding buffer for a time period sufficient to reversibly bind the at least one nucleic acid to the at least one magnetic particle to form at least one modified magnetic particle, (c) separating the at least one modified magnetic particle from the solution, (d) washing the at least one modified magnetic particle with at least one wash buffer; and (e) combining the at least one modified magnetic particle with an elution buffer Kits comprising these buffers and magnetic particles are also disclosed herein.

Abstract: A solar energy collector and a method for manufacturing the same. The solar energy collector has a solar chip, conductive wires connected to the solar chip, and a securing line that secures the solar chip and the conductive wires. The solar energy collector is rollable, foldable and expandable.

Abstract: Display mode management systems and methods. The system comprises a plurality of supported display modes, and a processing module. The processing module receives an expected display mode, and determines whether the expected display mode is among the supported display modes. If not, a specific display mode is selected from the supported display modes. The resolution of the specific display mode is smaller than and closest to that of the expected display mode among the supported display modes. The specific display mode is set as the display mode of a device.

Abstract: Display mode management systems and methods. The system comprises a plurality of supported display modes, and a processing module. The processing module receives an expected display mode, and determines whether the expected display mode is among the supported display modes. If not, a specific display mode is selected from the supported display modes. The resolution of the specific display mode is smaller than and closest to that of the expected display mode among the supported display modes. The specific display mode is set as the display mode of a device.