Abstract: Disclosed are cyclic urea-containing compounds that are useful as antiarrhythmic and/or antifibrillatory agents. These compounds have the following structure: ##STR1## where X and Y are each independently selected from various cyclic moieties; R.sub.5 is a substituted or unsubstituted C.sub.2 alkyl (thus providing a 6-membered cyclic urea); and R.sub.1, R.sub.2, R.sub.3, R.sub.4, L, and A are as defined in the specification. Also disclosed are compositions containing the compounds and methods of treating humans or other mammals afflicted with cardiac arrhythmias and/or cardiac fibrillation by administration of the compounds/compositions.

Abstract: The novel cyclic urethanes, and their pharmaceutically-acceptable salts and esters, described herein which are useful as antiarrhythmic and antifibrillatory agents and have the following general structure: ##STR1## wherein (a) X is a saturated or unsaturated, 5-, 6-, or 7-membered heterocycle or carbocycle;(b) Y is a substituted or unsubstituted, saturated or unsaturated, 5-, 6-, or 7-membered heterocyclic ring or carbocyclic ring, or is nil;(c) L is selected from the group consisting of alkylamino, alkenylamino, alkylimino, alkenylimino and acylamino; wherein the nitrogen atom thereof is bound to the nitrogen atom at the 3-position of the cyclic urethane ring moiety;(d) A is a substituted or unsubstituted, saturated or unsaturated, straight-chain or branched, C.sub.1 -C.sub.8 heteroalkyl; or a substituted or unsubstituted, saturated or unsaturated heterocycle having 6- or 7-members which may not have an oxygen atom; and A has one nitrogen atom which is adjacent to R.sub.

Abstract: Urethane-containing amino steroids having the general chemical formula: ##STR1## wherein a, b, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.14 and Z are as defined in the specification. Also disclosed are pharmaceutical composition and the use of the compounds/composition in the treatment of congestive heart failure.

Abstract: The cyclic ureas, and the pharmaceutically-acceptable salts and esters thereof, of the present invention are useful as antiarrhythmic and antifibrillatory agents and have the following general structure: ##STR1## wherein X, Y, A, L, R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are defined as in the Specification.

Abstract: The 4-oxocyclic ureas and the pharmaceutically acceptable salts and esters thereof, of the present invention are useful as antiarrhythmic and antifibrillatory agents and have the following general structure: ##STR1## wherein X, Y, A, L, R, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are defined as in the specification.

Abstract: Certain 5-phenyl-2-furoic acid hydrazides of the formula: ##STR1## wherein X represents 4-chloro, 4-fluoro, 3-trifluoromethyl or hydrogen, R.sub.1 represents hydrogen or methyl, R.sub.2 represents acetyl, isopropyl or methyl, and R.sub.1 and R.sub.2 taken together represent isopropylidene or 4-pyridinylmethylene are useful as anti-inflammatory agents.

Abstract: 2-[2-(5-Phenylfurfurylamino)ethyl]pyridines are useful as antihypertensive agents.

Abstract: 5-(4-Aminophenyl)-2-thiophenecarboximidamide hydrochloride hemihydrate is useful as an antidepressant agent.

Abstract: 5-(3-Trifluoromethylphenyl)-2-furancarboxylic acid 2-(1-methylethylidene)hydrazide is an effective skeletal muscle relaxant.

Abstract: 5-(4-Chlorophenyl)-2-furanmethyl methyl ketone is useful as an antifungal agent.

Abstract: 2-[5-(4-Chlorophenyl)furfuryl]-1,3,-propanediol is useful as an anti-inflammatory and antifungal agent.

Abstract: 2-(5-p-Chlorophenyl-2-furyl)-5-methyl-1,3,4-oxadiazole is useful as an anti-inflammatory agent.

Abstract: 5-(p-Nitrophenyl)-2-furaldehyde 2-(2-hydroxyethyl)hydrazone is useful as an anti-inflammatory.

Abstract: Certain 5-(4-nitrophenyl)-2-furanmethanamines are useful as anthelmintic agents.

Abstract: N,N-Dimethyl-5-phenyl-2-furamides are useful as anti-inflammatory agents.

Abstract: 7-Nitro-2-Benzofurancarboximidamide Hydrochloride is useful as an antidepressant.

Abstract: 2-??5-(4-Chlorophenyl)furfurylamino!methyl!pyridine dihydrochloride is useful as an anti-inflammatory agent.

Abstract: The compound 2-[5-(4-chlorophenyl)-2-furanyl]-5-mercapto-1,3,4-oxidiazole potassium salt is useful as an antifungal agent.

Abstract: Bis-[(5-p-chlorophenyl)furfuryl]amine hydrochloride is useful as an anti-inflammatory agent.

Abstract: 5-(2-Nitrophenyl)-2-furancarboximidoyl morpholine or pyrrolidine hydrochloride are useful as antidepressants.