Abstract: The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.

Abstract: The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.

Abstract: An embedded memory includes a memory interface circuit, a cell array, and a peripheral circuit. The memory interface circuit receives at least a clock signal, a non-clock signal, and a setup-hold time control setting, and includes a programmable path delay circuit that is used to set a path delay of at least one of a clock path and a non-clock path according to the setup-hold time control setting. The clock path is used to deliver the clock signal, and the non-clock path is used to deliver the non-clock signal. The peripheral circuit is used to access the cell array according to at least the clock signal provided from the clock path and the non-clock signal.

Abstract: The present invention relates to bispecific chimeric polypeptide assembly compositions comprising bulking moieties linked to binding domains by cleavable release segments that, when cleaved are capable of concurrently binding effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable chimeric polypeptide assembly compositions.

Abstract: A sense amplifier for reading a via Read-Only Memory (Via-ROM) is provided. The sense amplifier includes a read circuit, an adaptive keeper circuit and a leakage monitor circuit. The read circuit is connected to the via-ROM. The adaptive keeper circuit is connected to the read circuit. The leakage monitor circuit is connected to the adaptive keeper circuit for forming a current mirror, such that the adaptive keeper circuit compensates a read voltage of a memory cell whose via is opened when a bit-line leakage is happened.

Abstract: Disclosed are systems that include a plurality of solid state rechargeable battery cells. The system can be configured to power a drivetrain and can include a rolled substrate and at least one electrochemical cell overlying the surface region of the rolled substrate. The electrochemical cell can include a positive electrode, a solid state layer, a negative electrode, and an electrically conductive material.

Abstract: A method for the continuous or semi-batch manufacture of a solid-state battery device using a high speed process. The method can include forming multiple repeating stacks of thin film layers overlying a substrate in order to form multiple solid state batteries connected in series or parallel, wherein forming the multiple repeating stacks of thin film layers includes forming a polymer interlayer. The method can also include stacking multiple stacks of thin film layers of multi-layer battery cells connected in parallel or in series.

Abstract: An integrated energy storage system can include a first, second, and third energy storage units and a controller. The first energy storage units can have a gravimetric energy density of greater than 180 Wh/kg and volumetric energy density greater than 450 Wh/L in an environmental temperature above 0° C., the second energy storage units can have a gravimetric power density of greater than 450 W/kg and volumetric power density greater than 1080 W/L in an environmental temperature above 0° C., and the third energy storage units can be configured to operate in an environmental temperature as low as ?100° C. The controller can be programmed to receive inputs from voltage sensors, current sensors, and temperature sensors, and to allocate the current or power among the first, second, or third energy storage units depending on a power consumption from an application load and an environmental temperature.

Abstract: The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.

Abstract: A high speed deposition apparatus for the manufacture of solid state batteries. The apparatus can be used for the manufacture of solid state multilayer stacked battery devices via a vacuum deposition process. In various embodiments, the manufacturing apparatus can include a containment vessel, a reactor region, a process region, a work piece, one or more vacuum chambers, and an energy source. A complete stack of battery layers can be manufactured in a single vacuum cycle, having background gas, pressure, and deposition rate optimized and controlled for the deposition of each layer. The work piece can include a drum and a substrate, which can be a commercial polymer or metallic web, that are temperature controlled. Masks can be used to delineate or shape layers within the multi-layer stacked electrochemical device manufactured by embodiments of the apparatus.

Abstract: A method of producing a monolithically integrated high energy density solid-state battery device. The method can include positioning a substrate and depositing one or more stacked monolithically integrated high energy density solid-state electrochemical cells in series or in parallel configurations sequentially or individually. Each of these cells can have a first barrier layer, a cathode current collector deposited overlying the first barrier layer, a cathode overlying the electrically conductive layer, an anode, an anode current collector deposited overlying the solid state layer of negative electrode material, and a second barrier layer.

Abstract: A pulsed laser can be used to ablate the desired thin film layers at a desired location, to a desired depth, without impinging significantly upon other layers. The battery cell layer order may be optionally optimized to aid in ease of laser ablation. The laser process can isolate layers of thin film within sufficient proximity to at least one edge of the final thin film battery stack to optimize active battery area.

Abstract: A multi-layered solid-state battery device can have a substrate member having a surface region and a thin film battery device layer overlying the barrier material. The thin film battery device layer can comprise a cathode current collector, a cathode device, an electrolyte, an anode device, and an anode current collector. The device can have a non-planar surface region configured from the thin film battery device and a first polymer material overlying the thin film battery device and configured to fill in a gap region of the non-planar surface region and a planarizing surface region configured from the first polymer material.

Abstract: A data line control circuit has a data line driving circuit and a write-assist data line driving circuit. The data line driving circuit is used to drive differential data lines during a write operation of at least one memory cell. The write-assist data line driving circuit is used to drive at least one write-assist data line during the write operation of the at least one memory cell, wherein the at least one write-assist data line is isolated from the differential data lines, and is driven to have a first voltage transition from a first voltage level to a second voltage level, such that one of the differential data lines has a second voltage transition from a third voltage level to a fourth voltage level that is induced by the first voltage transition via capacitive coupling.

Abstract: A sense amplifier for reading a via Read-Only Memory (Via-ROM) is provided. The sense amplifier includes a read circuit, an adaptive keeper circuit and a leakage monitor circuit. The read circuit is connected to the via-ROM. The adaptive keeper circuit is connected to the read circuit. The leakage monitor circuit is connected to the adaptive keeper circuit for forming a current mirror, such that the adaptive keeper circuit compensates a read voltage of a memory cell whose via is opened when a bit-line leakage is happened.

Abstract: The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.

Abstract: The present invention relates to binding fusion protein compositions comprising targeting moieties linked to extended recombinant polypeptide (XTEN), binding fusion protein-drug conjugate compositions, and XTEN-drug conjugate compositions, isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of diseases, disorders, and conditions.

Abstract: An embedded memory includes a memory interface circuit, a cell array, and a peripheral circuit. The memory interface circuit receives at least a clock signal, a non-clock signal, and a setup-hold time control setting, and includes a programmable path delay circuit that is used to set a path delay of at least one of a clock path and a non-clock path according to the setup-hold time control setting. The clock path is used to deliver the clock signal, and the non-clock path is used to deliver the non-clock signal. The peripheral circuit is used to access the cell array according to at least the clock signal provided from the clock path and the non-clock signal.

Abstract: The present invention relates to compositions comprising biologically active proteins linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of glucose-related diseases, metabolic diseases, coagulation disorders, and growth hormone-related disorders and conditions.

Abstract: The present invention relates to compositions comprising glucose regulating peptides linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of glucose regulating peptide-related diseases, disorders, and conditions.