Patents by Inventor Chia-Ying James Lin

Chia-Ying James Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12357606
    Abstract: Controlled release hydrogel formulations of one or more simvastatin metabolites 3?-hydroxy simvastatin (hSV), 6?-exomethylene simvastatin (eSV), 3?,5?-dihydrodiol simvastatin, 3?,5?-dihydrodiol simvastatin (dSV), simvastatin-beta-hydroxy acid (SVA), and methods for the treatment of patients suffering from injured or degenerating substantially avascular cartilaginous tissue.
    Type: Grant
    Filed: July 21, 2023
    Date of Patent: July 15, 2025
    Assignee: University of Cincinnati
    Inventor: Chia-Ying James Lin
  • Publication number: 20240075183
    Abstract: Decellularized matrix microspheres comprising a polymeric material and a donor tissue are provided. Also disclosed are structures containing a plurality of decellularized matrix microspheres incorporating a first polymer and a donor tissue; and a second polymer, wherein the decellularized matrix microspheres and the second polymer are in the form of a filament. Methods of treating a tissue injury employing the matrix microspheres and structures described as well as their methods of manufacture are also provided.
    Type: Application
    Filed: June 13, 2023
    Publication date: March 7, 2024
    Inventors: Chia-Ying James Lin, Stacey Gruber, Patrick W. Whitlock, Paulomi Ghosh
  • Publication number: 20230381136
    Abstract: Controlled release hydrogel formulations of one or more simvastatin metabolites 3?-hydroxy simvastatin (hSV), 6?-exomethylene simvastatin (eSV), 3?,5?-dihydrodiol simvastatin, 3?,5?-dihydrodiol simvastatin (dSV), simvastatin-beta-hydroxy acid (SVA), and methods for the treatment of patients suffering from injured or degenerating substantially avascular cartilaginous tissue.
    Type: Application
    Filed: July 21, 2023
    Publication date: November 30, 2023
    Applicant: University of Cincinnati
    Inventor: Chia-Ying James Lin
  • Patent number: 11744821
    Abstract: Controlled release hydrogel formulations of one or more simvastatin metabolites 3?-hydroxy simvastatin (hSV), 6?-exomethylene simvastatin (eSV), 3?,5?-dihydrodiol simvastatin, 3?,5?-dihydrodiol simvastatin (dSV), simvastatin-beta-hydroxy acid (SVA), and methods for the treatment of patients suffering from injured or degenerating substantially avascular cartilaginous tissue.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: September 5, 2023
    Assignee: University of Cincinnati
    Inventor: Chia-Ying James Lin
  • Patent number: 11712496
    Abstract: Decellularized matrix microspheres comprising a polymeric material and a donor tissue are provided. Also disclosed are structures containing a plurality of decellularized matrix microspheres incorporating a first polymer and a donor tissue; and a second polymer, wherein the decellularized matrix microspheres and the second polymer are in the form of a filament. Methods of treating a tissue injury employing the matrix microspheres and structures described as well as their methods of manufacture are also provided.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: August 1, 2023
    Assignees: University of Cincinnati, Children's Hospital Medical Center
    Inventors: Chia-Ying James Lin, Stacey Gruber, Patrick W. Whitlock, Paulomi Ghosh
  • Patent number: 11376117
    Abstract: Various aspects of the disclosure relate to a tracheal implant comprising (a) a trachea processed to comprise one or more incisions providing a helical configuration to the processed trachea; and (b) a subject-specific synthetic support.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: July 5, 2022
    Assignees: University of Cincinnati, Children's Hospital Medical Center
    Inventors: Chia-Ying James Lin, John van Aalst, Stacey Gruber, Alessandro de Alarcon, Michael A. Helmrath
  • Publication number: 20210154168
    Abstract: Controlled release hydrogel formulations of one or more simvastatin metabolites 3?-hydroxy simvastatin (hSV), 6?-exomethylene simvastatin (eSV), 3?,5?-dihydrodiol simvastatin, 3?,5?-dihydrodiol simvastatin (dSV), simvastatin-beta-hydroxy acid (SVA), and methods for the treatment of patients suffering from injured or degenerating substantially avascular cartilaginous tissue.
    Type: Application
    Filed: May 15, 2018
    Publication date: May 27, 2021
    Inventor: Chia-Ying James Lin
  • Publication number: 20200289702
    Abstract: Decellularized matrix microspheres comprising a polymeric material and a donor tissue are provided. Also disclosed are structures containing a plurality of decellularized matrix microspheres incorporating a first polymer and a donor tissue; and a second polymer, wherein the decellularized matrix microspheres and the second polymer are in the form of a filament. Methods of treating a tissue injury employing the matrix microspheres and structures described as well as their methods of manufacture are also provided.
    Type: Application
    Filed: October 26, 2018
    Publication date: September 17, 2020
    Inventors: Chia-Ying James Lin, Stacey Gruber, Patrick W. Whitlock, Paulomi Ghosh
  • Publication number: 20200253727
    Abstract: Various aspects of the disclosure relate to a tracheal implant comprising (a) a trachea processed to comprise one or more incisions providing a helical configuration to the processed trachea; and (b) a subject-specific synthetic support.
    Type: Application
    Filed: August 31, 2018
    Publication date: August 13, 2020
    Inventors: Chia-Ying James Lin, John van Aalst, Stacey Gruber, Alessandro de Alarcon, Michael A. Helmrath