Patents by Inventor Chiaki Ishii

Chiaki Ishii has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210290777
    Abstract: A therapeutic agent for a metastatic brain tumor comprising, as an active component, an antibody-drug conjugate in which a drug-linker represented by the following formula (wherein A represents a connecting position to an antibody) is conjugated to the antibody via a thioether bond and/or a method of treatment for a metastatic brain tumor, comprising administering the antibody-drug conjugate to a subject in need of the treatment for a metastatic brain tumor.
    Type: Application
    Filed: July 30, 2019
    Publication date: September 23, 2021
    Applicant: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Kiyoshi SUGIHARA, Chiaki ISHII
  • Publication number: 20210290775
    Abstract: A pharmaceutical composition, wherein an antibody-drug conjugate in which a drug-linker represented by the following formula (wherein A represents a connecting position to an antibody) is conjugated to the antibody via a thioether bond, and a tubulin inhibitor are administered in combination, and a method of treatment, wherein the antibody-drug conjugate and the tubulin inhibitor are administered in combination to a subject.
    Type: Application
    Filed: August 5, 2019
    Publication date: September 23, 2021
    Applicant: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Yusuke OGITANI, Chiaki ISHII, Yasuki KAMAI, Kiyoshi SUGIHARA, Shotaro NAGASE
  • Publication number: 20190314362
    Abstract: A pharmaceutical composition and a therapeutic method wherein an antibody-drug conjugate and an immune checkpoint inhibitor are administered in combination, and the antibody-drug conjugate is an antibody-drug conjugate in which a drug-linker represented by the following formula (wherein A represents the connecting position to an antibody) is conjugated to the antibody via a thioether bond; and a pharmaceutical composition and a therapeutic method for use in treatment of a disease that can be ameliorated through an antitumor immunity-activating effect wherein the antibody-drug conjugate is included.
    Type: Application
    Filed: December 11, 2017
    Publication date: October 17, 2019
    Applicant: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Tomomi IWATA, Chiaki ISHII, Teiji WADA, Saori ISHIDA, Yasuki KAMAI
  • Publication number: 20040121377
    Abstract: Arrays of separated lipid bilayers are disclosed. Also disclosed are methods of using the arrays and methods of forming the arrrays. In addition, the invention provides useful systems and methods for selectively removing, collecting, and reconstitute lipid bilayers from specified regions of a surface. A stream of detergent solution is directed over a preformed bilayer, resulting in the removal of bilayer material. Diffusion-limited mixing between adjacent flows at low Reynolds number provides confinement of this stripping solution and, consequently, high precision. The freshly exposed surface allows formation of new connected bilayer when exposed to lipid vesicles. In conjunction with surface micropatterning and electrophoretic manipulation, the invention also provides a membrane-based separation/purification strategy.
    Type: Application
    Filed: October 6, 2003
    Publication date: June 24, 2004
    Inventors: Chiaki Ishii, Steven G. Boxer, Lance Kam