Patents by Inventor Chiaki Senoo
Chiaki Senoo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8058408Abstract: Using an undifferentiated mouse CL6 cell line, DMSO was added to induce its differentiation into cardiac muscular cells in order to obtain gene fragments whose expression elevated upon the induction. The isolated gene had zinc finger domains and showed a significant homology to the Sp1 family genes. Furthermore, a human gene corresponding to this mouse gene was isolated. The protein encoded by this gene existed in the nucleus and bonded to a GC-box. The protein was revealed to repress the transcription regulatory activity of the CMV promoter and thus serves as a transcription factor.Type: GrantFiled: January 30, 2009Date of Patent: November 15, 2011Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Chiaki Senoo, Mariko Numata
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Patent number: 7732149Abstract: Cell strains with ligand-dependent (factor-dependent) proliferation are super-infected with antibody libraries against each of the various receptor chains. Antibody genes are recovered from strains that autonomously grow by the autocrine stimulation by agonistic antibodies formed by appropriate combinations, enabling effective screening of agonistic antibodies. In this method, effective screening can be carried out using antibodies as libraries. Furthermore, the manipulations are simple, and there is no need for complicated operations.Type: GrantFiled: April 25, 2003Date of Patent: June 8, 2010Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Tetsuo Kojima, Chiaki Senoo
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Publication number: 20090182124Abstract: Using an undifferentiated mouse CL6 cell line, DMSO was added to induce its differentiation into cardiac muscular cells in order to obtain gene fragments whose expression elevated upon the induction. The isolated gene had zinc finger domains and showed a significant homology to the Sp1 family genes. Furthermore, a human gene corresponding to this mouse gene was isolated. The protein encoded by this gene existed in the nucleus and bonded to a GC-box. The protein was revealed to repress the transcription regulatory activity of the CMV promoter and thus serves as a transcription factor.Type: ApplicationFiled: January 30, 2009Publication date: July 16, 2009Inventors: Chiaki Senoo, Mariko Numata
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Publication number: 20090035799Abstract: Two novel trypsin-family serine proteases specifically expressed in adult mouse testis (“Tespec PRO-1” and “Tespec PRO-2”), and a novel trypsin-family serine protease derived from mouse (“Tespec PRO-3”) have been isolated. Also, two novel trypsin-family serine proteases derived from human (“Tespec PRO-2” and “Tespec PRO-3”) have been isolated. It has been suggested that these proteins are involved in sperm differentiation and maturation, and sperm functions (e.g., fertilization). Therefore, these proteins are useful for development of novel therapeutics and diagnostics for infertility, as well as for development of novel contraceptives.Type: ApplicationFiled: September 8, 2008Publication date: February 5, 2009Inventors: Chiaki SENOO, Mariko Numata
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Patent number: 7485714Abstract: Using an undifferentiated mouse CL6 cell line, DMSO was added to induce its differentiation into cardiac muscular cells in order to obtain gene fragments whose expression elevated upon the induction. The isolated gene had zinc finger domains and showed a significant homology to the Sp1 family genes. Furthermore, a human gene corresponding to this mouse gene was isolated. The protein encoded by this gene existed in the nucleus and bonded to a GC-box. The protein was revealed to repress the transcription regulatory activity of the CMV promoter and thus serves as a transcription factor.Type: GrantFiled: June 14, 2001Date of Patent: February 3, 2009Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Chiaki Senoo, Mariko Numata
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Publication number: 20080075712Abstract: The present inventors succeeded in separating bispecific antibodies that functionally substitute for ligands of type I interferon receptors comprising two types of molecules: AR1 chain and AR2 chain. Furthermore, the present inventors succeeded in producing bispecific antibodies that substitute for the enzyme reaction-accelerating function of blood coagulation factor VIII/activated blood coagulation factor VIII, which bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X.Type: ApplicationFiled: October 14, 2003Publication date: March 27, 2008Inventors: Kunihiro Hattori, Tetsuo Kojima, Taro Miyazaki, Tetsuhiro Soeda, Chiaki Senoo, Osamu Natori, Keiko Kasutani, Shinya Ishii
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Publication number: 20060204496Abstract: Animals were immunized with either the A or B chain of a receptor, and then mRNA was extracted from the spleen cells of the animals, and the variable regions of the L and H chains were isolated by RT-PCR using primers for variable regions comprising CDRs. Single-chain Fv was synthesized by assembly PCR to construct a phage library. Clones for antigen-bound antibodies were concentrated and cloned by panning. An expression vector for scFv-CH1-Fc was prepared by inserting a single-chain variable region between CH1-hinge-CH2-CH3 and the signal sequence for animal cells. Various combinations of such expression vectors were introduced into cells to express antibodies, and antibody clones exhibiting ligand-like activity were selected.Type: ApplicationFiled: November 28, 2003Publication date: September 14, 2006Inventors: Tetsuo Kojima, Chiaki Senoo, Osamu Natori, Keiko Kasutani, Shiny Ishi
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Publication number: 20050250144Abstract: Selection of clones having the kinase and/or phosphatase-like structure from clones which had been isolated and the structures thereof had been determined in the Helix Research Institute (helix clones; Japanese Patent Application No. 2000-183767) was conducted. Two novel genes were provided by carrying out homology search for all the helix clones by using the amino acid sequences of known kinases and phosphatases as queries. The genes are expected to be involved in intracellular signal transduction. The physiological functions of the inventive genes can be tested by using reporter gene assay systems capable of detecting signal transduction. The proteins of the present invention are useful as target molecules in drug discovery and in the development of new pharmaceuticals.Type: ApplicationFiled: April 19, 2005Publication date: November 10, 2005Inventors: Toshio Ota, Takao Isogai, Tetsuo Nishikawa, Koji Hayashi, Kaoru Otsuka, Jun-Ichi Yamamoto, Shizuko Ishii, Tomoyasu Sugiyama, Ai Wakamatsu, Keiichi Nagai, Tetsuji Otsuki, Shin-Ichi Funahashi, Chiaki Senoo, Jin-Ichi Nezu
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Publication number: 20050164307Abstract: Cell strains with ligand-dependent (factor-dependent) proliferation are super-infected with antibody libraries against each of the various receptor chains. Antibody genes are recovered from strains that autonomously grow by the autocrine stimulation by agonistic antibodies formed by appropriate combinations, enabling effective screening of agonistic antibodies. In this method, effective screening can be carried out using antibodies as libraries. Furthermore, the manipulations are simple, and there is no need for complicated operations.Type: ApplicationFiled: April 25, 2003Publication date: July 28, 2005Inventors: Tetsuo Kojima, Chiaki Senoo
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Publication number: 20030162205Abstract: Using an undifferentiated mouse CL6 cell line, DMSO was added to induce its differentiation into cardiac muscular cells in order to obtain gene fragments whose expression elevated upon the induction. The isolated gene had zinc finger domains and showed a significant homology to the Sp1 family genes. Furthermore, a human gene corresponding to this mouse gene was isolated. The protein encoded by this gene existed in the nucleus and bonded to a GC-box. The protein was revealed to repress the transcription regulatory activity of the CMV promoter and thus serves as a transcription factor.Type: ApplicationFiled: April 28, 2003Publication date: August 28, 2003Inventors: Chiaki Senoo, Mariko Numata
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Publication number: 20030082776Abstract: Selection of clones having the kinase and/or phosphatase-like structure from clones which had been isolated and the structures thereof had been determined in the Helix Research Institute (helix clones; Japanese Patent Application No. 2000-183767) was conducted. Twelve novel genes were provided by carrying out homology search for all the helix clones by using the amino acid sequences of known kinases and phosphatases as queries. The genes are expected to be involved in intracellular signal transduction. The physiological functions of the inventive genes can be tested by using reporter gene assay systems capable of detecting signal transduction. The proteins of the present invention are useful as target molecules in drug discovery and in the development of new pharmaceuticals.Type: ApplicationFiled: January 29, 2002Publication date: May 1, 2003Inventors: Toshio Ota, Takao Isogai, Tetsuo Nishikawa, Koji Hayashi, Kaoru Otsuka, Jun-Ichi Yamamoto, Shizuko Ishii, Tomoyasu Sugiyama, Ai Wakamatsu, Keiichi Nagai, Tetsuji Otsuki, Shin-Ichi Funahashi, Chiaki Senoo, Jun-Ichi Nezu
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Publication number: 20030017480Abstract: Selection of clones having the kinase and/or phosphatase-like structure from clones which had been isolated and the structures thereof had been determined in the Helix Research Institute (helix clones; Japanese Patent Application No. 2000-183767) was conducted. Two novel genes were provided by carrying out homology search for all the helix clones by using the amino acid sequences of known kinases and phosphatases as queries. The genes are expected to be involved in intracellular signal transduction. The physiological functions of the inventive genes can be tested by using reporter gene assay systems capable of detecting signal transduction. The proteins of the present invention are useful as target molecules in drug discovery and in the development of new pharmaceuticals.Type: ApplicationFiled: January 29, 2002Publication date: January 23, 2003Inventors: Toshio Ota, Takao Isogai, Tetsuo Nishikawa, Koji Hayashi, Kaoru Otsuka, Jun-Ichi Yamamoto, Shizuko Ishii, Tomoyasu Sugiyama, Ai Wakamatsu, Keiichi Nagai, Tetsuji Otsuki, Shin-Ichi Funahashi, Chiaki Senoo, Jun-Ichi Nezu
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Patent number: 5800982Abstract: The present invention relates to an NS4-related antigenic peptide capable of reacting specifically with antibodies directed against Group I of hepatitis C virus (HCV); to an NS4-related antigenic peptide capable of reacting specifically with antibodies directed against Group II of HCV; to a kit for identifying HCV Groups I or II which comprises said peptides in separate sections; and to methods for grouping HCV. The peptides of the present invention can be used to detect HCV Groups I or II specifically as well as the detection of patients having the mixed infection, by which HCV Group II-infected patients can receive early interferon treatment effectively. The peptides are also useful for diagnosis of HCV infection.Type: GrantFiled: July 24, 1996Date of Patent: September 1, 1998Assignee: Tonen CorporationInventors: Akira Hasegawa, Noboru Maki, Shintaro Yagi, Tomiko Kashiwakuma, Kenjiro Yamaguchi, Naoko Ikeguchi, Tomoko Kobayashi, Chiaki Senoo