Patents by Inventor Chie OKUYAMA

Chie OKUYAMA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bispecific antibody binding to human TLR2 and human TLR4
    Patent number: 10253105
    Abstract: The present application provides a bispecific antibody for preventing or treating an immune inflammatory disease by acting on both human TLR2 and human TLR4 to inhibit human TLR2- and human TLR4-mediated immune inflammatory effects. More specifically, the provided bispecific antibody is a bispecific antibody for human TLR2 and human TLR4, including a heavy chain variable region of an anti-human TLR2 antibody consisting of the amino acid sequence of amino acid numbers 1 to 120 of SEQ ID NO: 4; a light chain variable region of an anti-human TLR2 antibody consisting of the amino acid sequence of amino acid numbers 1 to 113 of SEQ ID NO: 6; a heavy chain variable region of an anti-human TLR4 antibody consisting of the amino acid sequence of amino acid numbers 491 to 609 of SEQ ID NO: 4; and a light chain variable region of an anti-human TLR4 antibody consisting of the amino acid sequence of amino acid numbers 625 to 732 of SEQ ID NO: 4.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: April 9, 2019
    Assignee: Astellas Pharma Inc.
    Inventors: Satoshi Takeuchi, Masahito Sato, Jotarou Suzuki, Shinji Soga, Jun Takasaki, Koji Aoyama, Chie Okuyama
  • NOVEL BISPECIFIC ANTIBODY BINDING TO HUMAN TLR2 AND HUMAN TLR4
    Publication number: 20160355602
    Abstract: [Problem] To provide a bispecific antibody for preventing or treating an immune inflammatory disease by acting on both human TLR2 and human TLR4 to inhibit human TLR2- and human TLR4-mediated immune inflammatory effects. [Means for Solution] Provided is a bispecific antibody for human TLR2 and human TLR4, including a heavy chain variable region of an anti-human TLR2 antibody consisting of the amino acid sequence of amino acid numbers 1 to 120 of SEQ ID NO: 4; a light chain variable region of an anti-human TLR2 antibody consisting of the amino acid sequence of amino acid numbers 1 to 113 of SEQ ID NO: 6; a heavy chain variable region of an anti-human TLR4 antibody consisting of the amino acid sequence of amino acid numbers 491 to 609 of SEQ ID NO: 4; and a light chain variable region of an anti-human TLR4 antibody consisting of the amino acid sequence of amino acid numbers 625 to 732 of SEQ ID NO: 4.
    Type: Application
    Filed: February 27, 2015
    Publication date: December 8, 2016
    Applicant: ASTELLAS PHARMA INC.
    Inventors: Satoshi TAKEUCHI, Masahito SATO, Jotarou SUZUKI, Shinji SOGA, Jun TAKASAKI, Koji AOYAMA, Chie OKUYAMA