Abstract: A bottle partition frame, at least includes adapters, blocking strips and three-way connectors. The adapter has plugged holes at two adjacent sides thereof so that the blocking strips can be plugged in the plugged holes of the adapters which further has a locking hole located in an indentation at a corner thereof for being passed by a locking piece, so that the adapter can be fixed on the corner of the flat board. Furthermore, according to the demands of different objects, the blocking strips can be cut into proper lengths and plugged into the plugged holes of the three-way connectors for assembling, and then, through the engaging portion at the lower end of the through hole of the three-way connector, the three-way connector can be assembled with another blocking strip. Hence, the present invention solves the drawback that the known bottle partition device needs to be locked on the side walls of the drawer.