Patents by Inventor Chieko Kitada
Chieko Kitada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 8778871Abstract: The invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, etc.). By modifying the constituent amino acids of metastin with specific modifying groups, metastin derivatives having more improved blood stability, etc. than native metastin and showing excellent cancer metastasis suppressing activity or cancer growth suppressing activity have been found. Furthermore, it has been found that these metastin derivatives exhibit effects of suppressing gonadotropic hormone secretion, suppressing sex hormone secretion, etc., which are wholly different from the effects heretofore known.Type: GrantFiled: October 1, 2008Date of Patent: July 15, 2014Assignee: Takeda Pharmaceutical Company LimitedInventors: Chieko Kitada, Taiji Asami, Naoki Nishizawa
-
Patent number: 8361968Abstract: The present invention provides a metastin derivative in which the amino acids comprising metastin were modified by alternative chemical substituents resulting in metastin derivitives, having excellent blood stability and exhibiting cancer metastasis inhibiting action or cancer growth inhibiting action.Type: GrantFiled: June 29, 2011Date of Patent: January 29, 2013Assignee: Takeda Pharmaceutical Company LimitedInventors: Chieko Kitada, Taiji Asami, Naoko Nishizawa, Tetsuya Ohtaki, Naoki Tarui, Hirokazu Matsumoto
-
Publication number: 20120015868Abstract: The present invention provides a metastin derivative in which the amino acids comprising metastin were modified by alternative chemical substituents resulting in metastin derivitives, having excellent blood stability and exhibiting cancer metastasis inhibiting action or cancer growth inhibiting action.Type: ApplicationFiled: June 29, 2011Publication date: January 19, 2012Applicant: Takeda Pharmaceutical Company LimitedInventors: Chieko Kitada, Taiji Asami, Naoko Nishizawa, Tetsuya Ohtaki, Naoki Tarui, Hirokazu Matsumoto, Jiro Noguchi, Hisanori Matsui
-
Publication number: 20110052563Abstract: Metastin, compounds that promote the activity of metastin or its receptors and the like are excellent gonadal function improving agents, ovulation inducers or promoters, gonadotropic hormone secretion promoters, gonadotropic hormone secretion inhibitors, sex hormone secretion promoters, sex hormone secretion inhibitors, etc., and can be used as agents for preventing/treating sterility, hormone-sensitive cancers, endometriosis, etc. Metastin and its receptors are useful for screening for these pharmaceuticals.Type: ApplicationFiled: February 23, 2010Publication date: March 3, 2011Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Tetsuya Ohtaki, Hisanori Matsui, Hirokazu Matsumoto, Chieko Kitada
-
Patent number: 7799533Abstract: This invention relates to a novel polypeptide involving in the modulation of central nervous system function, circulatory function, immune function, gastrointestinal function, metabolic function, reproductive function, etc., it can be used as a drug for treating or preventing a variety of diseases, e.g. HIV infection or AIDS (acquired immune deficiency syndrome) or the like.Type: GrantFiled: July 2, 2008Date of Patent: September 21, 2010Assignee: Takeda Pharmaceutical Company LimitedInventors: Shuji Hinuma, Kazuhiko Tatemoto, Masaki Hosoya, Yugo Habata, Ryo Fujii, Chieko Kitada
-
Patent number: 7754220Abstract: Metastin, compounds that promote the activity of metastin or its receptors and the like are excellent gonadal function improving agents, ovulation inducers or promoters, gonadotropic hormone secretion promoters, gonadotropic hormone secretion inhibitors, sex hormone secretion promoters, sex hormone secretion inhibitors, etc., and can be used as agents for preventing/treating sterility, hormone-sensitive cancers, endometriosis, etc. Metastin and its receptors are useful for screening for these pharmaceuticals.Type: GrantFiled: March 11, 2004Date of Patent: July 13, 2010Assignee: Takeda Pharmaceutical Company LimitedInventors: Tetsuya Ohtaki, Hisanori Matsui, Hirokazu Matsumoto, Chieko Kitada
-
Patent number: 7691979Abstract: The present invention aims at providing an antibody, by which metastin or its derivative can be quantified specifically with a high sensitivity, a method of detecting/quantifying metastin or its derivative using the antibody, and a diagnostic agent (e.g., a diagnostic for pregnancy) the same. Specifically, an antibody capable of specifically reacting with a partial peptide at the N-terminus or C-terminus of a polypeptide having the amino acid sequence represented by SEQ ID NO: 1 or its derivative, and a method of detecting/quantifying metastin or its derivative using the antibody as well as a diagnostic agent using the same.Type: GrantFiled: August 2, 2006Date of Patent: April 6, 2010Assignee: Takeda Pharmaceutical Company LimitedInventors: Hirokazu Matsumoto, Yasuko Horikoshi, Chieko Kitada, Tetsuya Ohtaki
-
Patent number: 7671174Abstract: The present invention provides a ligand to GPR8, in particular polypeptides capable of binding to GPR8 or its amides or esters, or salts thereof, as well as the DNA encoding for such polypeptides. The ligand to GPR8 of the present invention is useful in developing receptor-binding assay systems with the use of a GPR8 expression system, for screening candidate compounds for drugs such as preventive/therapeutic agents for obesity, appetite stimulants, and prolactin production inhibitors.Type: GrantFiled: January 26, 2007Date of Patent: March 2, 2010Assignee: Takeda Pharmaceutical Company LimitedInventors: Masaaki Mori, Yukio Shimomura, Mioko Harada, Taiji Asami, Yoshio Matsumoto, Yuka Adachi, Tsukasa Sugo, Michiko Abe, Mika Goto, Chieko Kitada, Takuya Watanabe
-
Patent number: 7662574Abstract: The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.Type: GrantFiled: February 2, 2007Date of Patent: February 16, 2010Assignee: Takeda Pharmaceutical Company LimitedInventors: Takuya Watanabe, Kuniko Kikuchi, Yasuko Terao, Yasushi Shintani, Shuji Hinuma, Shoji Fukusumi, Ryo Fujii, Masaki Hosoya, Chieko Kitada
-
Publication number: 20090318365Abstract: The present invention provides a metastin derivative in which the amino acids comprising metastin were modified by alternative chemical substituents resulting in metastin derivatives, having excellent blood stability and exhibiting cancer metastasis inhibiting action or cancer growth inhibiting action.Type: ApplicationFiled: June 2, 2009Publication date: December 24, 2009Applicant: Takeda Pharmaceutical Company LimitedInventors: Chieko Kitada, Taiji Asami, Naoko Nishizawa, Tetsuya Ohtaki, Naoki Tarui, Hirokazu Matsumoto, Jiro Noguchi, Hisanori Matsui
-
Patent number: 7635751Abstract: The present invention relates to novel peptide derivatives, which are recognized as ligands to G-coupled protein receptor proteins. The peptide of the present invention can be used in (1) development of a receptor binding assay system using the expression system of the recombinant receptor protein and screening of candidates for pharmaceutical compounds, and (2) development of pharmaceutical preparations such as a neutral nerve function regulator, a circulatory function regulator, a cardiac function regulator, an immune function regulator, a digestive organ function regulator, a metabolic function regulator, a generative organ regulator or the like.Type: GrantFiled: March 22, 2001Date of Patent: December 22, 2009Assignee: Takada Pharmaceutical Company LimitedInventors: Chieko Kitada, Naoki Nishizawa, Shuji Hinuma, Masaki Hosoya
-
Publication number: 20090298765Abstract: The invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, etc.). By modifying the constituent amino acids of metastin with specific modifying groups, metastin derivatives having more improved blood stability, etc. than native metastin and showing excellent cancer metastasis suppressing activity or cancer growth suppressing activity have been found. Furthermore, it has been found that these metastin derivatives exhibit effects of suppressing gonadotropic hormone secretion, suppressing sex hormone secretion, etc., which are wholly different from the effects heretofore known.Type: ApplicationFiled: October 1, 2008Publication date: December 3, 2009Applicant: Takeda Pharmaceutical Company LimitedInventors: Chieko Kitada, Taiji Asami, Naoki Nishizawa
-
Patent number: 7625869Abstract: The invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, etc.). By modifying the constituent amino acids of metastin with specific modifying groups, metastin derivatives having more improved blood stability, etc. than native metastin and showing excellent cancer metastasis suppressing activity or cancer growth suppressing activity have been found. Furthermore, it has been found that these metastin derivatives exhibit effects of suppressing gonadotropic hormone secretion, suppressing sex hormone secretion, etc., which are wholly different from the effects heretofore known.Type: GrantFiled: June 23, 2005Date of Patent: December 1, 2009Assignee: Takeda Pharmaceutical Company LimitedInventors: Chieko Kitada, Taiji Asami, Naoki Nishizawa
-
Patent number: 7608409Abstract: The present invention relates to rat cerebellum-derived and human brain-derived G protein coupled receptor proteins or salts thereof, their partial peptides, amides, esters or salts thereof, ligands to the same, a method/kit for screening compounds that alter the binding property between the ligands and the G protein coupled receptor proteins, compounds obtained by the screening or salts thereof, and antibodies to the G protein coupled receptor proteins.Type: GrantFiled: October 24, 2007Date of Patent: October 27, 2009Assignee: Takeda Pharmaceutical Company LimitedInventors: Takuya Watanabe, Yasuko Terao, Yasushi Shintani, Tetsuya Ohtaki, Kimiko Kanehashi, Chieko Kitada
-
Patent number: 7598351Abstract: The anti-19P2 ligand monoclonal antibodies of the invention (in particular P2L-1Ca) have very high binding ability and can neutralize the arachidonic acid metabolite releasing activity of the 19P2 ligand. Therefore, they can be used, among others, as diagnostic, prophylactic and/or therapeutic agents for various diseases caused by some or other abnormality in the pituitary function modulating activity (e.g. prolactin secretion promoting activity), central nervous system modulating activity and pancreatic function modulating activity, among others, supposedly possessed by the 19P2 ligand.Type: GrantFiled: December 3, 2004Date of Patent: October 6, 2009Assignee: Takeda Pharmaceutical Company LimitedInventors: Hirokazu Matsumoto, Chieko Kitada, Shuji Hinuma
-
Publication number: 20090075334Abstract: This invention relates to a novel polypeptide involving in the modulation of central nervous system function, circulatory function, immune function, gastrointestinal function, metabolic function, reproductive function, etc., it can be used as a drug for treating or preventing a variety of diseases, e.g. HIV infection or AIDS (acquired immune deficiency syndrome) or the like.Type: ApplicationFiled: July 2, 2008Publication date: March 19, 2009Applicant: Takeda Pharmaceutical Company LimitedInventors: Shuji Hinuma, Kazuhiko Tatemoto, Masaki Hosoya, Yugo Habata, Ryo Fujii, Chieko Kitada
-
Publication number: 20080312155Abstract: The invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, etc.). By modifying the constituent amino acids of metastin with specific modifying groups, metastin derivatives having more improved blood stability, etc. than native metastin and showing excellent cancer metastasis suppressing activity or cancer growth suppressing activity have been found. Furthermore, it has been found that these metastin derivatives exhibit effects of suppressing gonadotropic hormone secretion, suppressing sex hormone secretion, etc., which are wholly different from the effects heretofore known.Type: ApplicationFiled: June 23, 2005Publication date: December 18, 2008Inventors: Chieko Kitada, Taiji Asami, Naoki Nishizawa
-
Publication number: 20080305998Abstract: The present invention aims at providing a ligand to GPR8, its DNA, etc., and more particularly, a polypeptide capable of binding to GPR8 or its amides or esters, or salts thereof, as well as its DNA, etc. The ligand to GPR8 of the present invention is useful in developing a receptor-binding assay system with the use of a GPR8 expression system, screening candidate compounds for drugs such as preventive/therapeutic agents for obesity, appetite stimulants, prolactin production inhibitors, etc.Type: ApplicationFiled: January 26, 2007Publication date: December 11, 2008Inventors: Masaaki Mori, Yukio Shimomura, Mioko Harada, Taiji Asami, Yoshio Matsumoto, Yuka Adachi, Tsukasa Sugo, Michiko Abe, Mika Goto nee Mika Kurihara, Chieko Kitada, Takuya Watanabe
-
Patent number: 7410776Abstract: This invention relates to a novel polypeptide involving in the modulation of central nervous system function, circulatory function, immune function, gastrointestinal function, metabolic function, reproductive function, etc., it can be used as a drug for treating or preventing a variety of diseases, e.g. HIV infection or AIDS (acquired immune deficiency syndrome) or the like.Type: GrantFiled: June 27, 2002Date of Patent: August 12, 2008Assignee: Takeda Pharmaceutical Company LimitedInventors: Shuji Hinuma, Kazuhiko Tatemoto, Masaki Hosoya, Yugo Habata, Ryo Fujii, Chieko Kitada
-
Publication number: 20080131976Abstract: The present invention relates to rat cerebellum-derived and human brain-derived G protein coupled receptor proteins or salts thereof, their partial peptides, amides, esters or salts thereof, ligands to the same, a method/kit for screening compounds that alter the binding property between the ligands and the G protein coupled receptor proteins, compounds obtained by the screening or salts thereof, and antibodies to the G protein coupled receptor proteins.Type: ApplicationFiled: October 24, 2007Publication date: June 5, 2008Inventors: Takuya Watanabe, Yasuko Terao, Yasushi Shintani, Tetsuya Ohtaki, Kimiko Kanehashi, Chieko Kitada