Patents by Inventor Chieko Kitada

Chieko Kitada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8778871
    Abstract: The invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, etc.). By modifying the constituent amino acids of metastin with specific modifying groups, metastin derivatives having more improved blood stability, etc. than native metastin and showing excellent cancer metastasis suppressing activity or cancer growth suppressing activity have been found. Furthermore, it has been found that these metastin derivatives exhibit effects of suppressing gonadotropic hormone secretion, suppressing sex hormone secretion, etc., which are wholly different from the effects heretofore known.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: July 15, 2014
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Chieko Kitada, Taiji Asami, Naoki Nishizawa
  • Patent number: 8361968
    Abstract: The present invention provides a metastin derivative in which the amino acids comprising metastin were modified by alternative chemical substituents resulting in metastin derivitives, having excellent blood stability and exhibiting cancer metastasis inhibiting action or cancer growth inhibiting action.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: January 29, 2013
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Chieko Kitada, Taiji Asami, Naoko Nishizawa, Tetsuya Ohtaki, Naoki Tarui, Hirokazu Matsumoto
  • Publication number: 20120015868
    Abstract: The present invention provides a metastin derivative in which the amino acids comprising metastin were modified by alternative chemical substituents resulting in metastin derivitives, having excellent blood stability and exhibiting cancer metastasis inhibiting action or cancer growth inhibiting action.
    Type: Application
    Filed: June 29, 2011
    Publication date: January 19, 2012
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Chieko Kitada, Taiji Asami, Naoko Nishizawa, Tetsuya Ohtaki, Naoki Tarui, Hirokazu Matsumoto, Jiro Noguchi, Hisanori Matsui
  • Publication number: 20110052563
    Abstract: Metastin, compounds that promote the activity of metastin or its receptors and the like are excellent gonadal function improving agents, ovulation inducers or promoters, gonadotropic hormone secretion promoters, gonadotropic hormone secretion inhibitors, sex hormone secretion promoters, sex hormone secretion inhibitors, etc., and can be used as agents for preventing/treating sterility, hormone-sensitive cancers, endometriosis, etc. Metastin and its receptors are useful for screening for these pharmaceuticals.
    Type: Application
    Filed: February 23, 2010
    Publication date: March 3, 2011
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Tetsuya Ohtaki, Hisanori Matsui, Hirokazu Matsumoto, Chieko Kitada
  • Patent number: 7799533
    Abstract: This invention relates to a novel polypeptide involving in the modulation of central nervous system function, circulatory function, immune function, gastrointestinal function, metabolic function, reproductive function, etc., it can be used as a drug for treating or preventing a variety of diseases, e.g. HIV infection or AIDS (acquired immune deficiency syndrome) or the like.
    Type: Grant
    Filed: July 2, 2008
    Date of Patent: September 21, 2010
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Shuji Hinuma, Kazuhiko Tatemoto, Masaki Hosoya, Yugo Habata, Ryo Fujii, Chieko Kitada
  • Patent number: 7754220
    Abstract: Metastin, compounds that promote the activity of metastin or its receptors and the like are excellent gonadal function improving agents, ovulation inducers or promoters, gonadotropic hormone secretion promoters, gonadotropic hormone secretion inhibitors, sex hormone secretion promoters, sex hormone secretion inhibitors, etc., and can be used as agents for preventing/treating sterility, hormone-sensitive cancers, endometriosis, etc. Metastin and its receptors are useful for screening for these pharmaceuticals.
    Type: Grant
    Filed: March 11, 2004
    Date of Patent: July 13, 2010
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Tetsuya Ohtaki, Hisanori Matsui, Hirokazu Matsumoto, Chieko Kitada
  • Patent number: 7691979
    Abstract: The present invention aims at providing an antibody, by which metastin or its derivative can be quantified specifically with a high sensitivity, a method of detecting/quantifying metastin or its derivative using the antibody, and a diagnostic agent (e.g., a diagnostic for pregnancy) the same. Specifically, an antibody capable of specifically reacting with a partial peptide at the N-terminus or C-terminus of a polypeptide having the amino acid sequence represented by SEQ ID NO: 1 or its derivative, and a method of detecting/quantifying metastin or its derivative using the antibody as well as a diagnostic agent using the same.
    Type: Grant
    Filed: August 2, 2006
    Date of Patent: April 6, 2010
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Hirokazu Matsumoto, Yasuko Horikoshi, Chieko Kitada, Tetsuya Ohtaki
  • Patent number: 7671174
    Abstract: The present invention provides a ligand to GPR8, in particular polypeptides capable of binding to GPR8 or its amides or esters, or salts thereof, as well as the DNA encoding for such polypeptides. The ligand to GPR8 of the present invention is useful in developing receptor-binding assay systems with the use of a GPR8 expression system, for screening candidate compounds for drugs such as preventive/therapeutic agents for obesity, appetite stimulants, and prolactin production inhibitors.
    Type: Grant
    Filed: January 26, 2007
    Date of Patent: March 2, 2010
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Masaaki Mori, Yukio Shimomura, Mioko Harada, Taiji Asami, Yoshio Matsumoto, Yuka Adachi, Tsukasa Sugo, Michiko Abe, Mika Goto, Chieko Kitada, Takuya Watanabe
  • Patent number: 7662574
    Abstract: The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.
    Type: Grant
    Filed: February 2, 2007
    Date of Patent: February 16, 2010
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Takuya Watanabe, Kuniko Kikuchi, Yasuko Terao, Yasushi Shintani, Shuji Hinuma, Shoji Fukusumi, Ryo Fujii, Masaki Hosoya, Chieko Kitada
  • Publication number: 20090318365
    Abstract: The present invention provides a metastin derivative in which the amino acids comprising metastin were modified by alternative chemical substituents resulting in metastin derivatives, having excellent blood stability and exhibiting cancer metastasis inhibiting action or cancer growth inhibiting action.
    Type: Application
    Filed: June 2, 2009
    Publication date: December 24, 2009
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Chieko Kitada, Taiji Asami, Naoko Nishizawa, Tetsuya Ohtaki, Naoki Tarui, Hirokazu Matsumoto, Jiro Noguchi, Hisanori Matsui
  • Patent number: 7635751
    Abstract: The present invention relates to novel peptide derivatives, which are recognized as ligands to G-coupled protein receptor proteins. The peptide of the present invention can be used in (1) development of a receptor binding assay system using the expression system of the recombinant receptor protein and screening of candidates for pharmaceutical compounds, and (2) development of pharmaceutical preparations such as a neutral nerve function regulator, a circulatory function regulator, a cardiac function regulator, an immune function regulator, a digestive organ function regulator, a metabolic function regulator, a generative organ regulator or the like.
    Type: Grant
    Filed: March 22, 2001
    Date of Patent: December 22, 2009
    Assignee: Takada Pharmaceutical Company Limited
    Inventors: Chieko Kitada, Naoki Nishizawa, Shuji Hinuma, Masaki Hosoya
  • Publication number: 20090298765
    Abstract: The invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, etc.). By modifying the constituent amino acids of metastin with specific modifying groups, metastin derivatives having more improved blood stability, etc. than native metastin and showing excellent cancer metastasis suppressing activity or cancer growth suppressing activity have been found. Furthermore, it has been found that these metastin derivatives exhibit effects of suppressing gonadotropic hormone secretion, suppressing sex hormone secretion, etc., which are wholly different from the effects heretofore known.
    Type: Application
    Filed: October 1, 2008
    Publication date: December 3, 2009
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Chieko Kitada, Taiji Asami, Naoki Nishizawa
  • Patent number: 7625869
    Abstract: The invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, etc.). By modifying the constituent amino acids of metastin with specific modifying groups, metastin derivatives having more improved blood stability, etc. than native metastin and showing excellent cancer metastasis suppressing activity or cancer growth suppressing activity have been found. Furthermore, it has been found that these metastin derivatives exhibit effects of suppressing gonadotropic hormone secretion, suppressing sex hormone secretion, etc., which are wholly different from the effects heretofore known.
    Type: Grant
    Filed: June 23, 2005
    Date of Patent: December 1, 2009
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Chieko Kitada, Taiji Asami, Naoki Nishizawa
  • Patent number: 7608409
    Abstract: The present invention relates to rat cerebellum-derived and human brain-derived G protein coupled receptor proteins or salts thereof, their partial peptides, amides, esters or salts thereof, ligands to the same, a method/kit for screening compounds that alter the binding property between the ligands and the G protein coupled receptor proteins, compounds obtained by the screening or salts thereof, and antibodies to the G protein coupled receptor proteins.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: October 27, 2009
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Takuya Watanabe, Yasuko Terao, Yasushi Shintani, Tetsuya Ohtaki, Kimiko Kanehashi, Chieko Kitada
  • Patent number: 7598351
    Abstract: The anti-19P2 ligand monoclonal antibodies of the invention (in particular P2L-1Ca) have very high binding ability and can neutralize the arachidonic acid metabolite releasing activity of the 19P2 ligand. Therefore, they can be used, among others, as diagnostic, prophylactic and/or therapeutic agents for various diseases caused by some or other abnormality in the pituitary function modulating activity (e.g. prolactin secretion promoting activity), central nervous system modulating activity and pancreatic function modulating activity, among others, supposedly possessed by the 19P2 ligand.
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: October 6, 2009
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Hirokazu Matsumoto, Chieko Kitada, Shuji Hinuma
  • Publication number: 20090075334
    Abstract: This invention relates to a novel polypeptide involving in the modulation of central nervous system function, circulatory function, immune function, gastrointestinal function, metabolic function, reproductive function, etc., it can be used as a drug for treating or preventing a variety of diseases, e.g. HIV infection or AIDS (acquired immune deficiency syndrome) or the like.
    Type: Application
    Filed: July 2, 2008
    Publication date: March 19, 2009
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Shuji Hinuma, Kazuhiko Tatemoto, Masaki Hosoya, Yugo Habata, Ryo Fujii, Chieko Kitada
  • Publication number: 20080312155
    Abstract: The invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, etc.). By modifying the constituent amino acids of metastin with specific modifying groups, metastin derivatives having more improved blood stability, etc. than native metastin and showing excellent cancer metastasis suppressing activity or cancer growth suppressing activity have been found. Furthermore, it has been found that these metastin derivatives exhibit effects of suppressing gonadotropic hormone secretion, suppressing sex hormone secretion, etc., which are wholly different from the effects heretofore known.
    Type: Application
    Filed: June 23, 2005
    Publication date: December 18, 2008
    Inventors: Chieko Kitada, Taiji Asami, Naoki Nishizawa
  • Publication number: 20080305998
    Abstract: The present invention aims at providing a ligand to GPR8, its DNA, etc., and more particularly, a polypeptide capable of binding to GPR8 or its amides or esters, or salts thereof, as well as its DNA, etc. The ligand to GPR8 of the present invention is useful in developing a receptor-binding assay system with the use of a GPR8 expression system, screening candidate compounds for drugs such as preventive/therapeutic agents for obesity, appetite stimulants, prolactin production inhibitors, etc.
    Type: Application
    Filed: January 26, 2007
    Publication date: December 11, 2008
    Inventors: Masaaki Mori, Yukio Shimomura, Mioko Harada, Taiji Asami, Yoshio Matsumoto, Yuka Adachi, Tsukasa Sugo, Michiko Abe, Mika Goto nee Mika Kurihara, Chieko Kitada, Takuya Watanabe
  • Patent number: 7410776
    Abstract: This invention relates to a novel polypeptide involving in the modulation of central nervous system function, circulatory function, immune function, gastrointestinal function, metabolic function, reproductive function, etc., it can be used as a drug for treating or preventing a variety of diseases, e.g. HIV infection or AIDS (acquired immune deficiency syndrome) or the like.
    Type: Grant
    Filed: June 27, 2002
    Date of Patent: August 12, 2008
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Shuji Hinuma, Kazuhiko Tatemoto, Masaki Hosoya, Yugo Habata, Ryo Fujii, Chieko Kitada
  • Publication number: 20080131976
    Abstract: The present invention relates to rat cerebellum-derived and human brain-derived G protein coupled receptor proteins or salts thereof, their partial peptides, amides, esters or salts thereof, ligands to the same, a method/kit for screening compounds that alter the binding property between the ligands and the G protein coupled receptor proteins, compounds obtained by the screening or salts thereof, and antibodies to the G protein coupled receptor proteins.
    Type: Application
    Filed: October 24, 2007
    Publication date: June 5, 2008
    Inventors: Takuya Watanabe, Yasuko Terao, Yasushi Shintani, Tetsuya Ohtaki, Kimiko Kanehashi, Chieko Kitada