Patents by Inventor Chieko Naba

Chieko Naba has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phosphonic diester derivatives
    Patent number: 5624918
    Abstract: The present invention provides a phosphonic diester derivative of the following general formula (1): ##STR1## wherein A represents an oxygen atom or a sulfur atom; R.sup.1, R.sup.2, R.sup.9 and R.sup.10 are the same or different and they each represent a hydrogen atom, a lower alkoxy group, a nitro group, a lower alkyl group, a halogen-substituted lower alkyl group or a halogen atom; R.sup.3 represents a phenyl group, --B--R.sup.6 (wherein B represents an oxygen atom or a sulfur atom and R.sup.6 represents a hydrogen atom, a lower alkyl group, a cycloalkyl group, a phenyl group, a phenyl(lower)alkyl group optionally having a halogen atom as a substituent on the phenyl ring, a phenoxy(lower)alkyl group, a lower alkoxycarbonyl(lower)alkyl group, a carboxy(lower)alkyl group or a lower alkenyl group) or --NR.sup.7 R.sup.8 (wherein R.sup.7 and R.sup.
    Type: Grant
    Filed: February 5, 1995
    Date of Patent: April 29, 1997
    Assignee: Otsuka Pharmaceutical Factory, Inc.
    Inventors: Yasuhisa Kurogi, Kazuyoshi Miyata, Shizuo Nakamura, Mitsuyoshi Kondo, Takeshi Iwamoto, Chieko Naba, Yoshihiko Tsuda, Yasuhide Inoue, Jun Kanaya, Keigo Sato
  • Phosphonic diester derivatives
    Patent number: 5527786
    Abstract: The present invention provides a phosphonic diester derivative of the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are the same or different and they each represent a hydrogen atom, a lower alkyl group, a halogen atom, a cyano group, a hydroxyl group, or a lower alkoxy group optionally having a halogen atom, a phenyl group or a hydroxypiperidino group as a substituent; R.sup.4 represents a hydrogen atom, a lower alkoxy group, a halogen atom, or a lower alkyl group optionally having a halogen atom or a cyano group as a substituent; and R.sup.5 and R.sup.6 are the same or different and they each represent a hydrogen atom or a lower alkyl group.The derivative of the present invention has excellent hypolipidemic, vasodepressor and hypoglycemic activities and is useful as therapeutic and preventive agents for hyperlipidemic diseases, hypertension and diabetes.
    Type: Grant
    Filed: April 19, 1995
    Date of Patent: June 18, 1996
    Assignee: Otsuka Pharmaceutical Factory, Inc.
    Inventors: Kazuyoshi Miyata, Yasuhisa Kurogi, Yoshihiko Tsuda, Kazuhiko Tsutsumi, Takeshi Iwamoto, Chieko Naba
  • Phosphonic diester derivatives
    Patent number: 5376665
    Abstract: The invention provides a phosphonic diester derivative of the general formula ##STR1## The phosphonic diester derivative of the invention has hypoglycemic and hypolipidemic activities, for instance, and is of value as an antidiabetic or anti-hyperlipidemic agent.
    Type: Grant
    Filed: January 14, 1994
    Date of Patent: December 27, 1994
    Assignee: Otsuka Pharmaceutical Factory, Inc.
    Inventors: Kazuyoshi Miyata, Yasuo Shoji, Yoshihiko Tsuda, Kazuhiko Tsutsumi, Yasuhide Inoue, Chieko Naba, Yasuhisa Kurogi