Patents by Inventor Chieko Yokoyama

Chieko Yokoyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies specific to human prostacyclin synthase
    Patent number: 7119176
    Abstract: The present invention clarifies the primary structure of human-originated PGIS and the nucleotide sequence encoding same. The PGIS and its DNA are useful as reagents for the development of therapeutic agents for the cardiovascular diseases induced by the production imbalance between PGI2 and TXA2, and as diagnostics for determining the in vivo tissue expression level and distribution of PGIS or mRNA thereof. Moreover, they can be used as therapeutic agents for cardiovascular diseases, which introduce PGIS and the like into human or other animals in a lesion-specific manner. The production method of the present invention is useful for the easy and efficient mass production of the human-originated PGIS. The antibody of the present invention is useful for the purification of the human-originated PGIS and immunohistochemical analysis of the cause of a disease.
    Type: Grant
    Filed: September 17, 2003
    Date of Patent: October 10, 2006
    Inventors: Tadashi Tanabe, Chieko Yokoyama
  • Method for treating or preventing inflammatory disorders
    Publication number: 20050080140
    Abstract: According to the present invention, the gene for IL-13, an anti-inflammatory cytokine, was shown to be a target of prostacyclin (PGI2)-activated Peroxisome proliferator-activated receptor (PPAR) ?. Furthermore, the PGI2-PPAR? signaling pathway was revealed to regulate the expression of IL-13 gene in human vascular endothelial cells, and controls inflammatory responses induced by proinflammatory cytokines through the production of IL-13 in an autocrine or paracrine manner. Thus, the present invention provides a method for treating or preventing inflammatory disorders, which comprises administering a therapeutically effective amount of PPAR? agonist into a subject. Furthermore, the present invention provides a method for treating or preventing inflammatory disorders, which comprises administering a prostacyclin synthase gene or a protein encoded by the gene into a subject.
    Type: Application
    Filed: August 20, 2004
    Publication date: April 14, 2005
    Applicant: AnGes MG, Inc.
    Inventors: Toshihisa Hatae, Chieko Yokoyama, Tadashi Tanabe
  • Antibodies specific to human prostacyclin synthase
    Publication number: 20040092722
    Abstract: The present invention clarifies the primary structure of human-originated PGIS and the nucleotide sequence encoding same. The PGIS and its DNA are useful as reagents for the development of therapeutic agents for the cardiovascular diseases induced by the production imbalance between PGI2 and TXA2, and as diagnostics for determining the in vivo tissue expression level and distribution of PGIS or mRNA thereof. Moreover, they can be used as therapeutic agents for cardiovascular diseases, which introduce PGIS and the like into human or other animals in a lesion-specific manner. The production method of the present invention is useful for the easy and efficient mass production of the human-originated PGIS. The antibody of the present invention is useful for the purification of the human-originated PGIS and immunohistochemical analysis of the cause of a disease.
    Type: Application
    Filed: September 17, 2003
    Publication date: May 13, 2004
    Inventors: Tadashi Tanabe, Chieko Yokoyama