Abstract: A formulation and a method for manufacturing an acne extraction patch. Water is added into polyvinyl alcohol and polyvinyl pyrrolidone to form an polymer solution. An adequate excipient is further added to form an optimal formulation. The formulation is coated directly onto the hydrophilic nonwovens or the nonwovens are placed over the release liner after coating the release liner with silicon coating. After the steps described above, the nonwovens are put into the dry oven for a two-step drying method at 55-90.degree. C., and 80-95.degree. C. A die-cut and package machine is used to cut an adequate patch. The patch is moistened with water and applied to the face or nose. The water solution of the formulation penetrates into the hair follicles or sebaceous glands. The lug of acne sticks to the polymer patch as the water evaporates. The acne is extracted from the hair follicle as the patch is removed.

Abstract: Scopolamine is a folksy cholinergic antagonist, and is used by parasympathetic nerves in autonomic nervous neurons as an anti-motion sickness drug or an anti-emesis drug. Since the human body most effectively absorbs this drug through the postauricular skin, the drug is administered by postauricular transdermal resorption patch. The penetrability of drug is increase by adding a dermal penetrative enhancer, because the penetration ability of patch-administered drugs is usually decreased by the penetrative blockade at dermal horny layers. The present invention discloses a penetration enhancer to increase dermal absorption and penetration of the cholinergic antagonist. The present invention finds that polyethylene and amide enhance penetration, about 2.2-2.8 fold. In accordance with the present invention, a penetration enhancer is added to the formulations of transdermal patch to increase the human body's absorption of scopolamine.

Abstract: A water retaining adhesive composition prepared by polymerizing and partially crosslinking 100 parts by weight of a 20 to 35 wt % solution of the acrylic polymer with 2 to 5 parts by weight of the amine group compound, amide group compound or amino group compound at a temperature of 20.degree. C. to 80.degree. C.; adjusting the pH value of the resultant partially crosslinked polymer to 6.0 to 7.0; and then sequentially compounding 10 to 40 parts by weight of modifiers and 2 to 5 parts by weight of water retaining agent in the partially crosslinked polymer. The modifier is a polyol, a polyalcohol or a poly(ether alcohol). The water retaining agent is 2-pyrrolidone-5-carboxylate.