Abstract: A biological device includes a substrate, a gate electrode, and a sensing well. The substrate includes a source region, a drain region, a channel region, a body region, and a sensing region. The channel region is disposed between the source region and the drain region. The sensing region is at least disposed between the channel region and the body region. The gate electrode is at least disposed on or above the channel region of the substrate. The sensing well is at least disposed adjacent to the sensing region.

Abstract: A biological device includes a substrate, a gate electrode, and a sensing well. The substrate includes a source region, a drain region, a channel region, a body region, and a sensing region. The channel region is disposed between the source region and the drain region. The sensing region is at least disposed between the channel region and the body region. The gate electrode is at least disposed on or above the channel region of the substrate. The sensing well is at least disposed adjacent to the sensing region.

Abstract: The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and/or CD3 (Cluster of Differentiation 3). The invention also relates to antibody conjugates (e.g., antibody-drug-conjugates) comprising the BCMA antibodies, compositions comprising the BCMA antibodies, and methods of using the BCMA antibodies and their conjugates for treating conditions associated with cells expressing BCMA (e.g., cancer or autoimmune disease). The invention further relates to heteromultimeric antibodies that specifically bind to CD3 and a tumor cell antigen, (e.g., bispecific antibodies that specifically bind to CD3 and BCMA). Compositions comprising such heteromultimeric antibodies, methods for producing and purifying such heterodimeric antibodies, and their use in diagnostics and therapeutics are also provided.

Abstract: A retrofitting method for a beam with an opening is disclosed. The retrofitting method provides a hoop cooperated with an inclined stirrup to form a reinforcement set. The hoop is used to enclose the opening; and the reinforcement set may be selectively adjusted according to the distance between the edge of opening and a column face. The retrofitting method and reinforcement set are not only suitable for openings located in the non-plastic hinge zone of the beam, but also suitable for the openings located in the plastic hinge zone.

Abstract: The present disclosure provides for antibody-oligonucleotide conjugates, methods of preparation thereof, and methods of use thereof. Also provided are related compounds, compositions and kits.

Abstract: A pixel circuit for an electronic display may include a memory to store a digital data signal indicative of a value within a data range. The pixel circuit may also include a light-emitting diode to emit light based at least in part on the digital data signal. The pixel circuit may also include an initialization transistor to initialize the pixel circuit before the light-emitting diode emits light and a driving transistor to activate based at least in part on the digital data signal.

Abstract: An electronic display may include a pixel circuit. The pixel circuit may include memory storage to store data values representative of image data to be depicted via the pixel circuit. The memory storage may also include memory components for storing bits of the data value. The pixel circuit may also include a light-emitting device for emitting light based at least in part on the data value and a controller. The controller may receive the data value and store the bits based on a mapping between the bits and the memory components. The mapping may be determined based on routing one or more of the bits associated with one or more defective memory components of the memory components to one or more other memory components of the memory components. The controller may also drive the light-emitting device to emit light based on the bits stored in accordance with the mapping.

Abstract: A connector clip is disclosed. The connector clip includes a base, a cover, a hinge coupling the cover and the base, and a fastener. The base has a first base side joined to a second base side via a connecting base side. The cover has a first cover side joined to a second cover side via a connecting cover side. The fastener holds the first base side and the first cover side in a fixed position when the connector clip is in a closed configuration in which the connecting base side is parallel to the connecting cover side. An internal cable opening is formed in part by the connecting base side and the connecting cover side when the connector clip is in the closed configuration. The connector clip secures a cable passing through the internal cable opening and connected to a board in its place in the closed configuration.

Abstract: Provided are methods of treating cancer that comprise administering a polypeptide (e.g. a fusion polypeptide) that comprises a SIRP? D1 domain variant and an Fc domain variant in combination with at least one chemotherapy agent and/or at least one therapeutic antibody. Also provided are related kits.

Abstract: A semiconductor package is provided, including a package component and a number of conductive features. The package component has a non-planar surface. The conductive features are formed on the non-planar surface of the package component. The conductive features include a first conductive feature and a second conductive feature respectively arranged in a first position and a second position of the non-planar surface. The height of the first position is less than the height of the second position, and the size of the first conductive feature is smaller than the size of the second conductive feature.

Abstract: A cable distribution box includes a base plate, a proximal wall extending from a first side of the base plate, a distal wall extending from a second side of the base plate, a latch formed on a third side of the base plate, and a cover plate extending from the proximal wall. The latch is configured to secure the cable distribution box to a chassis. The cover plate has a center portion that projects towards the base plate, such that the center portion is configured to wrap a cable thereon. The cover plate is foldable along a length of the proximal wall, relative to the base plate in a clamshell fashion, to enclose the wrapped cable between the cover plate and the base plate. The cover plate includes a locking mechanism that is configured to engage the distal wall, and secure the cover plate onto the base plate.

Abstract: A power tool includes an air spring cylinder. A piston is movably positioned within the cylinder and a driver blade and a rack are attached to the piston. The power tool includes a lifter gear including a lifter gear wheel portion, and a plurality of teeth extending radially from the lifter gear wheel portion and configured to engage the rack. A hub includes a first end operably connected to a motor output and a second end including a hub wheel portion. A first receptacle is provided in one of the lifter gear and the hub and a first bearing element extends from the other of the lifter gear and the hub into the first receptacle. A first elastomeric damper is positioned within the first receptacle between the first bearing element and a bearing element defined portion of the first receptacle.

Abstract: A data storage device includes a memory device and a controller coupled to the memory device. The controller is configured to receive a command, such as from a host device, to write data to the memory device, perform toggle mode (TM) encoding on the data, and send the TM encoded data to the memory device. The memory device is configured to receive the TM encoded data, decode the TM encoded data, and write the decoded data to a location within the memory device. The memory device is further configured to receive a read command to read data from a location within the memory device, read the data, TM encode the data, and send the TM encoded data to the controller. The controller is configured to receive and decode the TM encoded data, and send the decoded data to a host device.

Abstract: A storage apparatus includes non-volatile memory cells formed on a memory die, each memory cell configured to hold bits of data, and a control circuit formed on the memory die. The control circuit is configured to calculate parity data for data to be stored in the memory cells and program the memory cells to first distributions. The control circuit is also configured to read the memory cells in the first distributions, recover the data from results of reading the memory cells in the first distributions combined with the parity data, and further program the memory cells from the first distributions to second distributions to store the data. In some cases, the recovered data may have a high bit error rate. To handle higher bit error rates, the use of soft bit data is incorporated into an encoded foggy-fine scheme.

Abstract: A memory macro includes a first memory cell array, a first tracking circuit, a first and a second transistor. The first memory cell array includes rows of memory cells and columns of memory cells. The first tracking circuit includes a first set of memory cells configured as a first set of loading cells responsive to a first control signal, a second set of memory cells configured as a first set of pull-down cells responsive to a second control signal, and a first tracking bit line coupled to the first and second set of memory cells. The first set of pull-down cells or loading cells is configured to track a memory cell of the first memory cell array. The first and second transistor are coupled to the first tracking bit line, and configured to charge the first tracking bit line to a pre-charge voltage level responsive to a tracking enable signal.

Abstract: The present disclosure features signal-regulatory protein ? (SIRP-?) polypeptides and constructs that are useful, e.g., to target a cell (e.g., a cancer cell or a cell of the immune system), to increase phagocytosis of the target cell, to eliminate immune cells such as regulatory T-cells, to kill cancer cells, to treat a disease (e.g., cancer) in a subject, or any combinations thereof. The SIRP-? constructs include a high affinity SIRP-? D1 domain or variant thereof that binds CD47 with higher affinity than a wild-type SIRP-?. The SIRP-? polypeptides or constructs include a SIRP-? D1 variant fused to an Fc domain monomer, a human serum albumin (HSA), an albumin-binding peptide, or a polyethylene glycol (PEG) polymer. Compositions provided herein include (i) a polypeptide including a signal-regulatory protein ? (SIRP-?) D1 variant and (ii) an antibody.

Abstract: The present disclosure provides for antibody-oligonucleotide conjugates, methods of preparation thereof, and methods of use thereof. Also provided are related compounds, compositions and kits.

Abstract: Examples of devices with foldable display screens are described. In an example, the foldable display screen of the device includes a first portion, a second portion, and an intermediary portion between the first portion and the second portion. The device further includes a hinge joint coupled to the first portion and the second portion to fold the first portion and the second about the intermediary portion. Further, the device includes an actuating block abutting the intermediary portion and the hinge joint. The actuating block, in response to receiving a pressing force from a user on the intermediary portion above the actuating block, is to cause the hinge joint to operate and fold the foldable display screen.

Abstract: Examples of a foldable device having a flexible display panel and an adjusting mechanism therefor is described herein. In one example, the foldable device can include an enclosure having a first segment and a second segment connected to each other by a hinge and the flexible display panel is housed inside the enclosure. The adjusting mechanism is operably coupled to the enclosure and he flexible display panel. The adjusting mechanism can adjust a curvature of the flexible display panel to about a permissible curvature upon relative motion between the first segment and the second segment of the enclosure.

Abstract: A method of determining a target nucleic acid of interest using synthetic Phix sequences designed to match the target nucleic acid fragments. The sequencing error profile was generated using the synthetic Phix L and synthetic Phix S, and the sequencing read locations information on the patterned flow cell.