Abstract: A wireless authentication system for universal serial bus (USB) storage device has a USB storage device mounted on a computer unit with the storage device wirelessly connected to a remote device. The remote device has a dedicated application installed therein and transmitting authentication information to the storage device for establishing a dedicated link. A storage space of the storage device is set by the computer unit to be accessible. When users activate the remote device for sending out an operation command, the operation command includes at least one encryption command and at least one decryption command. The storage device performs a corresponding data management mode according to the operation command. Accordingly, the storage device can be wirelessly managed to enhance personal data security and operational convenience of the storage device.