Abstract: An optical radar includes an optical-signal receiving unit and an optical-signal pickup unit. The optical-signal receiving unit is configured to receive a reflected light. The optical-signal pickup unit is coupled to the optical-signal receiving unit and includes a first optical-signal filtering circuit and a second optical-signal filtering unit. The first optical-signal filtering circuit is configured to filter out a first interference pulse of the reflected light, wherein the first interference pulse has a first interference voltage value higher than a reference voltage. The second optical-signal filtering circuit is coupled to the first optical-signal filtering circuit and configured to generate a clock signal comprising a clock pulse; and filter out a second interference pulse that does not match the clock pulse in time point from the reflected light.

Abstract: Systems, methods, and non-transitory computer-readable media can determine contextual information associated with an environment including a vehicle and at least one agent for generating a computer simulation based on the environment. One or more behavior constraints for the at least one agent can be determined based on the contextual information. A set of trajectories can be generated based on the one or more behavior constraints. A trajectory can be selected from the set of trajectories based on determining that the trajectory satisfies one or more predetermined criteria. The computer simulation can be generated, wherein the computer simulation includes monitoring driving behavior of the vehicle in response to the vehicle interacting with the at least one agent based on the selected trajectory.

Abstract: Systems, methods, and non-transitory computer-readable media can determine contextual information associated with an environment including a vehicle and at least one agent for generating a computer simulation based on the environment. One or more behavior constraints for the at least one agent can be determined based on the contextual information. A set of trajectories can be generated based on the one or more behavior constraints. A trajectory can be selected from the set of trajectories based on determining that the trajectory satisfies one or more predetermined criteria. The computer simulation can be generated, wherein the computer simulation includes monitoring driving behavior of the vehicle in response to the vehicle interacting with the at least one agent based on the selected trajectory.

Abstract: The present invention includes substituted chromenones that are useful to inhibit the IRE1/XBP-1 pathway. In certain embodiments, the compounds of the invention inhibit IRE1's RNase activity. In other embodiments, the compounds of the invention are useful to treat or prevent a cancer that involve activation of the ER stress response. The invention also relates, in certain aspects, to the discovery that secretory IgM (sIgM) can orchestrate an immunosuppressive microenvironment by recruiting myeloid-derived suppressor cells (MDSCs) into different tumor models, such as but not limited to solid tumors (such as but not limited to lung cancer) and tumors that have high levels of secreted IgM. In certain embodiments, sIgM produced by B cells or CLL cells can contribute to the accumulation of MDSCs in a tumor. In other embodiments, inhibition of the IRE1/XBP-1 pathway can ablate, minimize, or reduce MDSC levels in a tumor.