Abstract: The present invention relates a method for vaccinating a mammal to produce an antibody against Enterobacteriaceae infection caused by Klebsiella pneumoniae, Salmonella typhi, or E. coli in central nervous system and/or peripheral blood circulation, which comprises administering an effective amount of an OmpK36/homologues or its derivatives to the mammal.

Abstract: Disclosed are lipopeptides or lipoproteins, related compositions, and related methods.

Abstract: An immunopeptide containing a T cell epitope from the tumor associated antigen L6 (TAL6) and a nucleic acid encoding the immunopeptide are described herein. The immunopeptide or its encoding nucleic acid can be used as a component of an immune composition for enhancing immune response against cancer cells that express TAL6.

Abstract: A method for enhancing a body's response to an immunogen is disclosed. The method comprises immunizing a subject in need thereof a vaccine composition in a water-in-oil (W/O/W) emulsion that comprises (a) an antigen; and (b) an adjuvant composition in a W/O/W emulsion. The adjuvant composition comprises: (i) a continuous aqueous phase comprising H2O; (ii) an oil phase comprising oil dispersed in the continuous aqueous phase, comprising an internal aqueous phase comprising H2O, being dispersed in the oil phase; and a physiologically acceptable lipophilic emulsifier selected from the group consisting of mannide monooleate and sorbitan esters, stabilizing the interface between the inner aqueous phase and the oil phase to form a water-in-oil (W/O) emulsion; and (iii) poly(ethylene glycol)-block-poly(lactide-co-?-caprolactone), stabilizing the interface between the oil phase and the continuous aqueous phase.

Abstract: Production of a lipidated protein in an E. coli strain adapted to membrane protein expression.

Abstract: A method for enhancing a body's response to an immunogen is disclosed. The method comprises immunizing a subject in need thereof a vaccine composition in a water-in-oil (W/O/W) emulsion that comprises (a) an antigen; and (b) an adjuvant composition in a W/O/W emulsion. The adjuvant composition comprises: (i) a continuous aqueous phase comprising H2O; (ii) an oil phase comprising oil dispersed in the continuous aqueous phase, comprising an internal aqueous phase comprising H2O, being dispersed in the oil phase; and a physiologically acceptable lipophilic emulsifier selected from the group consisting of mannide monooleate and sorbitan esters, stabilizing the interface between the inner aqueous phase and the oil phase to form a water-in-oil (W/O) emulsion; and (iii) poly(ethylene glycol)-block-poly(lactide-co-?-caprolactone), stabilizing the interface between the oil phase and the continuous aqueous phase.

Abstract: Disclosed are immunogenic composition, fusion proteins, and related methods for inducing immune response to dengue virus infection.

Abstract: This invention relates to, inter alia, an isolated lipidated polypeptide including a lipid moiety at the N-terminus and a plurality of epitopes, and methods of making and using the polypeptide.

Abstract: A method of producing a recombinant lipidated polypeptide in E. coli. The method includes providing an E. coli host cell adapted to express a recombinant lipidated polypeptide; and culturing the E. coli host cell in a minimal medium under conditions that allow expression of the polypeptide in lipidated form.

Abstract: A method for preparing and purifying recombinant lipoprotein Ag473 of Neisseria meningitidis (NM) group B isolates. The method can be used in large-scale production of vaccines for Neisseria meningitidis (NM) group B.

Abstract: A consensus peptide sequence designed for domain III of the envelope proteins of four serotypes of dengue virus and used in a vaccine against multiple serotypes of dengue virus is disclosed. The vaccine is able to elicit cross-neutralization antibody responses against multiple serotypes of dengue virus.

Abstract: An composition comprises (a) a continuous aqueous phase; (b) an oily phase; and (c) an amphiphilic emulsifying system comprising a block copolymer having the formula (A)p-(B)q-(C)r, in which (B)q is a hydrophilic block and (C)r is a hydrophobic block; wherein p, q and r are integers with the proviso that: if p is 0, then A is other than hydroxyl or reactive functional groups and the block copolymer is a diblock copolymer; B and C are each individual repeating) units; if p is >1, then the block copolymer is a triblock copolymer, in which (A)p is a hydrophobic block; the hydrophobic blocks (A)p and (C)r are each homopolymers or heteropolymers; the repeating units A and C are the same or different; and wherein the ratio q/(p+r) is sufficient high so that the hydrophilic-lipophilic balance value of the block copolymer is >10.

Abstract: An immunopeptide containing a T cell epitope from the tumor associated antigen L6 (TAL6) and a nucleic acid encoding the immunopeptide. The immunopeptide and its encoding nucleic acid can be used as a component of an immune composition for enhancing immune response against cancer cells that express TAL6.

Abstract: Disclosed are polypeptides and fusion proteins. Also disclosed are related immunotherapeutic compositions and methods.

Abstract: Disclosed are immunogenic composition, fusion proteins, and related methods for inducing immune response to dengue virus infection.

Abstract: Production in E. coli of a lipidated fusion protein containing a lipidating sequence derived from Ag473 and a target polypeptide.

Abstract: Disclosed are lipopeptides or lipoproteins, related compositions, and related methods.

Abstract: Production in E. coli of a lipidated fusion protein containing a lipidating sequence derived from Ag473 and a target polypeptide.

Abstract: A method for detecting a target with a specific marker includes: putting a specimen in a reactor, wherein the specimen contains a target with a specific marker, and the reactor has a plurality of biological probes arranged on the bottom; placing the reactor between a first electrode and a second electrode, wherein the area of the first electrode is different from the area of the second electrode; providing a power to the first electrode and the second electrode to generate an electric field for promoting the target to conjugate with the biological probes; and removing the specimen unconjugated with the biological probes. A system for detecting a target with a specific marker is also disclosed. The above-mentioned method and system is appropriate for massive and parallel detection with simpler operation and lower cost.

Abstract: Production of a lipidated protein in an E. coli strain adapted to membrane protein expression.