Abstract: A semiconductor structure includes a first interposer; a second interposer laterally adjacent to the first interposer, where the second interposer is spaced apart from the first interposer; and a first die attached to a first side of the first interposer and attached to a first side of the second interposer, where the first side of the first interposer and the first side of the second interposer face the first die.

Abstract: The present invention discloses a kind of centrifugal detection channel, including: a first chamber, at least one inlet channel, at least one buffer valve, at least one outlet channel, and a second chamber. Specifically, at least one inlet channel is connected to the first chamber. At least one buffer valve is connected to the inlet channel, including: a valve body and a transient chamber. At least one outlet channel is connected to the buffer valve. At least one second chamber is connected to the outlet channel. In addition, the detection devices and the detection methods comprising the centrifugal detection channel have also been proposed.

Abstract: The invention provides a viscometer and an operation method thereof. The viscometer comprises a disk and at least one microfluidic structure. The microfluidic structure is embedded in the disk and has a first chamber which is connected to a second chamber. The second chamber is provided with an annular chamber along the circumferential direction of the disk and comprises at least one indicator. Overall, the present viscometer and its operation method do utilize the oscillation amplitude of pendulum motion of the indicator to calculate a viscosity value (cP) of a sample which has already existed in the second chamber.

Abstract: In this invention, chromatography is integrated on a centrifugal platform to enable low-cost automated purification. Differing from the traditional chromatography method, purification and separation of a centrifugal compound collecting platform disclosed in the present invention mainly uses a centrifugal force to drive the fluid to flow outward in the radial direction when the motor rotates. The compounds to be separated react with the column packing during the flow, and the compounds with different polarities in the sample are gradually separated. The flow of the fluid can be governed by the motor and the geometry of the fluidic design such that compounds with different characteristics can be separated and collected in different collecting chambers.

Abstract: The present disclosure relates to a microfluidic-based analyzer, including a drive module and a microfluidic disc. On the microfluidic disk, a capillary is connected between a mixing chamber and a waste chamber. More particularly, the capillary is connected to the mixing chamber through a first access on the first radius of the microfluidic disc, and the capillary is connected to the waste chamber through a second access on the second radius of the microfluidic disk. Specifically, a turn of the capillary is disposed between the first access and the second access, in which a folding is configured on a third radius of the microfluidic disc. Overall, the aforementioned microfluidic-based analyzer is able to be operated in different rotational speeds and is capable of evacuating the mixing chamber and enhancing the washing efficiency.

Abstract: An immunodetection method is provided, including: providing a disk; providing a capture antibody on a substrate adding a sample to a reservoir; applying a first rotational speed to transfer the sample containing an antigen from the reservoir to a reaction chamber applying a second rotational speed to precipitate the sample on the substrate so as to combine the antigen in the sample with the capture antibody to obtain a first complex; using capillary force to make the sample flow out of the reaction chamber and to fill the flow channel; applying a third rotational speed to transfer the sample from the flow channel to the waste chamber; providing a detection antibody on the substrate to combine the detection antibody with the first complex to obtain a second complex; and detecting a spectral signal from the localized surface plasma resonance of the second complex.

Abstract: The present disclosure relates to a microfluidic-based analyzer, including a drive module and a microfluidic disc. On the microfluidic disk, a capillary is connected between a mixing chamber and a waste chamber. More particularly, the capillary is connected to the mixing chamber through a first access on the first radius of the microfluidic disc, and the capillary is connected to the waste chamber through a second access on the second radius of the microfluidic disk. Specifically, a turn of the capillary is disposed between the first access and the second access, in which a folding is configured on a third radius of the microfluidic disc. Overall, the aforementioned microfluidic-based analyzer is able to be operated in different rotational speeds and is capable of evacuating the mixing chamber and enhancing the washing efficiency.

Abstract: The invention provides an apparatus and methodology to carry out biochemical testing on a centrifugal platform using flow splitting technique. In conventional biochemical testing, reagents need to be loaded individually into each reservoir. By using the flow splitting technique in this invention, one reagent only need to be loaded once, then, it can be evenly distributed into each reaction chambers in single or multiple layers format. The invention greatly reduces the required manpower when large numbers of assays are integrated on one platform. Because of the invention, many medical examinations can be performed efficiently, thus reduce the waste of manpower, time and cost.

Abstract: The invention provides an apparatus and methodology to carry out biochemical testing on a centrifugal platform using flow splitting technique. In conventional biochemical testing, reagents need to be loaded individually into each reservoir. By using the flow splitting technique in this invention, one reagent only need to be loaded once, then, it can be evenly distributed into each reaction chambers in single or multiple layers format. The invention greatly reduces the required manpower when large numbers of assays are integrated on one platform. Because of the invention, many medical examinations can be performed efficiently, thus reduce the waste of manpower, time and cost.

Abstract: A microfluidic device has a body, multiple channels, multiple reservoirs and multiple capillary valves. The reservoirs are formed on the body. Each channel is formed on the body and connects to a corresponding reservoir. The channels include a main channel and at least one branch channel. The main channel is formed on the top of the body and extends in a direction from the center to a circumference of the body. Each capillary valve is mounted on a corresponding channel and at a distance substantially close to the center of the body so differences between the burst frequencies of the capillary valves are increased. The microfluidic device has an excellent flow control on sequentially releasing fluid through distinct burst frequencies of microcapillary valves.

Abstract: A microfluidic device has a body, multiple channels, multiple reservoirs and multiple capillary valves. The reservoirs are formed on the body. Each channel is formed on the body and connects to a corresponding reservoir. The channels include a main channel and at least one branch channel. The main channel is formed on the top of the body and extends in a direction from the center to a circumference of the body. Each capillary valve is mounted on a corresponding channel and at a distance substantially close to the center of the body so differences between the burst frequencies of the capillary valves are increased. The microfluidic device has an excellent flow control on sequentially releasing fluid through distinct burst frequencies of microcapillary valves.

Abstract: A manufacturing process for optical analysis discs including successive patterning operations and a related optical analysis discs thereby manufactured. The process includes providing a planar substrate layer, patterning on the planar substrate layer a spacing material forming a fluidic cavity configuration, and providing a cover layer bonded onto the planar substrate layer containing the fluidic cavity configuration. The optical analysis disc includes a planar substrate layer, a fluidic cavity configuration formed on the planar substrate layer by patterning a spacing adhesive material, and a cover layer bonded onto the planar substrate layer containing the fluidic cavity configuration.

Abstract: A process for manufacturing optical analysis discs with microfluidic structures and a disc made according thereto. The process includes the steps of providing a lens disc, patterning an intermediate adhesive layer with a pattern corresponding to predetermined microfluidic structures, providing a cover disc having molded microfluidic structures, and applying the cover disc onto the intermediate adhesive layer to match the molded microfluidic structures to the pattern to bond the cover disc onto the lens disc.

Abstract: Rotating apparatus has a separation zone structure having solid components spaced apart to form gaps. The gaps are large enough to allow disperse particles to change position relative to the center of rotation by passing through the separation zone structure. The gaps are too small to allow particle agglutinants to pass through the separation zone structure.