Patents by Inventor Chih-Hung Lee

Chih-Hung Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Signal amplification circuits for receiving/transmitting signals according to input signal
    Patent number: 8310314
    Abstract: One exemplary signal amplification circuit used for processing an input signal includes an input stage, a plurality of output stages, and a selecting stage. The input stage has an input node for receiving the input signal and an output node for outputting an intermediate signal. The output stages are coupled to a plurality of output ports of the signal amplification circuit, respectively. Each of the output stages generates a corresponding processed signal to a corresponding output port according to a gain and a signal derived from the intermediate signal of the input stage when enabled. The selecting stage is arranged for selectively coupling the output node of the input stage to at least one of the output stages.
    Type: Grant
    Filed: September 6, 2010
    Date of Patent: November 13, 2012
    Assignee: Mediatek Inc.
    Inventor: Chih-Hung Lee
  • PRODRUGS OF COMPOUNDS THAT INHIBIT TRPV1 RECEPTOR
    Publication number: 20120277190
    Abstract: Compounds of formula (I) wherein A, R1, R2, and R3 are defined in the specification, and which are useful as therapeutic compounds particularly for treating disorders or conditions associated with inflammation, pain, bladder overactivity, urinary incontinence, and other disorders caused by or exacerbated by TRPV1.
    Type: Application
    Filed: July 9, 2012
    Publication date: November 1, 2012
    Inventors: Arthur R. Gomtsyan, Erol K. Bayburt, John R. Koenig, Kennan C. Marsh, Robert G. Schmidt, JR., Chih-Hung Lee, Weili Wang, Jerome F. Daanen, Brian S. Brown
  • TRPV1 Antagonists
    Publication number: 20120245163
    Abstract: Disclosed herein are compounds of formula (I) or pharmaceutically acceptable salts, solvates, or combinations thereof, wherein X1, X2, X3, X4, J, K, L, X5, X6, Rb, G2, and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
    Type: Application
    Filed: March 22, 2012
    Publication date: September 27, 2012
    Applicant: ABBOTT LABORATORIES
    Inventors: Arthur Gomtsyan, Jerome F. Daanen, Gregory A. Gfesser, Michael E. Kort, Chih-Hung Lee, Heath A. McDonald, Pamela S. Puttfarcken, Eric A. Voight, Philip R. Kym
  • 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof
    Patent number: 8268853
    Abstract: Compounds of formula (I) are useful in treating conditions or disorders ameliorated by ?4?2 positive allosteric modulators. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: September 18, 2012
    Assignee: Abbott Laboratories
    Inventors: Michael R. Schrimpf, Diana L. Nersesian, Chih-Hung Lee, Ramin Faghih, Gregory A. Gfesser
  • Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
    Patent number: 8247413
    Abstract: Compounds of formula (I) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity, wherein X1, X2, X3, X4, X5, R5, R6, R7, R8a, R8b, R9, Z1, Z2 and L are as defined in the description.
    Type: Grant
    Filed: February 19, 2008
    Date of Patent: August 21, 2012
    Assignee: Abbott Laboratories
    Inventors: Chih-Hung Lee, Erol K. Bayburt, Stanley Didomenico, Jr., Irene Drizin, Arthur R. Gomtsyan, John R. Koenig, Richard J. Perner, Robert G. Schmidt, Jr., Sean C. Turner, Tammie K. White, Guo Zhu Zheng
  • Prodrugs of compounds that inhibit TRPV1 receptor
    Patent number: 8232309
    Abstract: Compounds of formula (I) wherein A, R1, R2, and R3 are defined in the specification, and which are useful as therapeutic compounds particularly for treating disorders or conditions associated with inflammation, pain, bladder overactivity, urinary incontinence, and other disorders caused by or exacerbated by TRPV1.
    Type: Grant
    Filed: October 27, 2006
    Date of Patent: July 31, 2012
    Assignee: Abbott Laboratories
    Inventors: Arthur R. Gomtsyan, Erol K. Bayburt, John R. Koenig, Kennan C. Marsh, Robert G. Schmidt, Jr., Chih-Hung Lee, Weili Wang, Jerome F. Daanen, Brian S. Brown
  • FUSED COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR
    Publication number: 20120190845
    Abstract: The present invention discloses novel compounds of general formula (I) or a pharmaceutically acceptable salt or prodrug thereof (in which X1-X5, R5-R8b, Z1-Z2 and Ar1 are defined herein), a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain in mammals, and pharmaceutical compositions including those compounds and a process for making those compounds.
    Type: Application
    Filed: November 9, 2011
    Publication date: July 26, 2012
    Inventors: Arthur R. Gomtsyan, Erol K. Bayburt, Chih-Hung Lee, John R. Koenig, Robert G. Schmidt, Kirill A. Lukin, Gilles Chamboumier, Margaret Chi-Ping Hsu, Robert M. Leanna, Russell D. Cink
  • SPIROCYCLIC AZAADAMANTANE DERIVATIVES AND METHODS OF USE
    Publication number: 20120065219
    Abstract: The invention relates to compounds that are spirocyclic azaadamantane derivatives, particularly spirocyclic azaadamantanyl ether or amine derivatives, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
    Type: Application
    Filed: November 15, 2011
    Publication date: March 15, 2012
    Applicant: ABBOTT LABORATORIES
    Inventors: Jianguo Ji, Michael R. Schrimpf, Kevin B. Sippy, Tao Li, Chih-Hung Lee
  • SIGNAL AMPLIFICATION CIRCUITS FOR RECEIVING/TRANSMITTING SIGNALS ACCORDING TO INPUT SIGNAL
    Publication number: 20120056681
    Abstract: One exemplary signal amplification circuit used for processing an input signal includes an input stage, a plurality of output stages, and a selecting stage. The input stage has an input node for receiving the input signal and an output node for outputting an intermediate signal. The output stages are coupled to a plurality of output ports of the signal amplification circuit, respectively. Each of the output stages generates a corresponding processed signal to a corresponding output port according to a gain and a signal derived from the intermediate signal of the input stage when enabled. The selecting stage is arranged for selectively coupling the output node of the input stage to at least one of the output stages.
    Type: Application
    Filed: September 6, 2010
    Publication date: March 8, 2012
    Inventor: Chih-Hung Lee
  • METHOD FOR DETERMINING A RISK, FOR A SUBJECT, OF SUFFERING FROM ATOPIC DERMATITIS OR SEVERITY OF ATOPIC DERMATITIS FOR A SUBJECT SUFFERING FROM ATOPIC DERMATITIS AND METHOD FOR USING A SINGLE-NUCLEOTIDE POLYMORPHISM RS12313273 AS A BIOMARKER FOR DETERMINING THE DEVELOPMENT OR SEVERITY OF ATOPIC DERMATITIS
    Publication number: 20120028827
    Abstract: The invention provides a method for determining a risk, for a subject, of suffering from atopic dermatitis, including: obtaining a biosample of the subject; detecting the presence of the single-nucleotide polymorphism rs12313273 (C/T) at position 30881 of the ORAI1 gene (SEQ ID No.: 1) in the biosample; and determining the risk, for the subject, of suffering from atopic dermatitis, wherein the presence of a C allele or genotype CC of the single-nucleotide polymorphism rs12313273 (C/T) indicates that the subject is at increased risk for suffering from atopic dermatitis.
    Type: Application
    Filed: July 28, 2011
    Publication date: February 2, 2012
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Wei-Chiao Chang, Chih-Hung Lee, Suh-Hang Juo, Wei-Chiao Chen, Hsin-Su Yu
  • ANTAGONISTS OF THE TRPV1 RECEPTOR AND USES THEREOF
    Publication number: 20120022103
    Abstract: The present application is directed to compounds that are TRPV1 antagonists and have formula (I) wherein variables Ar1, L1, R1, R2, R3, R4, R5, Y1, Y2, and Y3, are as defined in the description, which are useful for treating disorders caused by or exacerbated by vanilloid receptor activity.
    Type: Application
    Filed: September 29, 2011
    Publication date: January 26, 2012
    Applicant: ABBOTT LABORATORIES
    Inventors: Erol K. Bayburt, Jerome F. Daanen, Arthur R. Gomtsyan, Steven P. Latshaw, Chih-hung Lee, Robert G. Schmidt, JR.
  • Spirocyclic azaadamantane derivatives and methods of use
    Patent number: 8076350
    Abstract: The invention relates to compounds that are spirocyclic azaadamantane derivatives derivatives, particularly spirocyclic azaadamantanyl ether or amine derivatives, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
    Type: Grant
    Filed: November 20, 2007
    Date of Patent: December 13, 2011
    Assignee: Abbott Laboratories
    Inventors: Jianguo Ji, Michael R. Schrimpf, Kevin B. Sippy, Tao Li, Chih-Hung Lee
  • Fused compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
    Patent number: 8071762
    Abstract: The present invention discloses novel compounds of general formula (I) or a pharmaceutically acceptable salt or prodrug thereof (in which X1-X5, R5-R8b, Z1-Z2 and Ar1 are defined herein), a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain in mammals, and pharmaceutical compositions including those compounds and a process for making those compounds.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: December 6, 2011
    Assignee: Abbott Laboratories
    Inventors: Arthur R. Gomtsyan, Erol K. Bayburt, Chih-Hung Lee, John R. Koenig, Robert G. Schmidt, Kirill A. Lukin, Gilles Chambournier, Margaret Chi-Ping Hsu, Marvin R. Leanna, Russell D. Cink
  • Antagonists of the TRPV1 receptor and uses thereof
    Patent number: 8030504
    Abstract: The present application is directed to compounds that are TRPV1 antagonists and have formula (I) wherein variables Ar1, L1, R1, R2, R3, R4, R5, Y1, Y2, and Y3, are as defined in the description, which are useful for treating disorders caused by or exacerbated by vanilloid receptor activity.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: October 4, 2011
    Assignee: Abbott Laboratories
    Inventors: Erol K. Bayburt, Jerome F. Daanen, Arthur R. Gomtsyan, Steven P. Latshaw, Chih-hung Lee, Robert G. Schmidt, Jr.
  • Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor
    Patent number: 8026256
    Abstract: Compounds of formula (I) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence, or bladder overactivity.
    Type: Grant
    Filed: October 26, 2005
    Date of Patent: September 27, 2011
    Assignee: Abbott Laboratories
    Inventors: Arthur Gomtsyan, Erol K. Bayburt, John R. Koenig, Chih-Hung Lee
  • Frequency Synthesizer
    Publication number: 20110210799
    Abstract: A frequency synthesizer. The frequency synthesizer comprises a harmonic locked phase/frequency detector, a low pass filter, a voltage controlled oscillator, and a frequency divider. The harmonic locked phase/frequency detector receives a reference signal and a divided signal. The low pass filter is coupled to the harmonic locked phase/frequency detector. The voltage controlled oscillator is coupled to the low pass filter and provides an output signal. The frequency divider is coupled between the voltage controlled oscillator and the harmonic locked phase/frequency detector. Frequency of the divided signal is a harmonic frequency of the reference signal.
    Type: Application
    Filed: May 11, 2011
    Publication date: September 1, 2011
    Applicants: MediaTek Inc., National Taiwan University
    Inventors: Shen-Iuan Liu, Chih-Hung Lee
  • Amide derivatives as positive allosteric modulators and methods of use thereof
    Patent number: 7994223
    Abstract: The invention relates to novel amide derivatives that are positive allosteric modulators of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.
    Type: Grant
    Filed: July 22, 2010
    Date of Patent: August 9, 2011
    Assignee: Abbott Laboratories
    Inventors: Michael R. Schrimpf, Kathleen H. Mortell, Diana L. Nersesian, Chih-Hung Lee, Bruce Clapham
  • PHARMACEUTICAL COMPOSITIONS AND THEIR METHODS OF USE
    Publication number: 20110190314
    Abstract: The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an ?4?2 positive allosteric modulator, a method of using the same, and a related article of manufacture.
    Type: Application
    Filed: April 5, 2011
    Publication date: August 4, 2011
    Applicant: Abbott Laboratories
    Inventors: Murali Gopalakrishnan, Marie P. Honore, Chih-Hung Lee, John Malysz, Jianguo Ji, Tao Li, Michael R. Schrimpf, Kevin B. Sippy, David J. Anderson
  • Methods for Treating Pain
    Publication number: 20110178121
    Abstract: The present invention is directed to methods of treating pain by administering a therapeutically effective amount of an ?7 nAChR ligand or a pharmaceutically acceptable salt thereof, to a mammal in need of treatment thereof and to pharmaceutical compositions comprising such a compound or salt.
    Type: Application
    Filed: December 22, 2010
    Publication date: July 21, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: Chih-Hung Lee, Michael R. Schrimpf, Timothy A. Esbenshade, Chang Z. Zhu
  • Clock data recovery circuit
    Patent number: 7983361
    Abstract: A clock data recovery circuit. The clock data recovery circuit comprises a transmission line, a phase locked loop, a voltage controlled oscillator, a phase selector, and a D flip-flop. The transmission line receives an input signal. The phase locked loop receives the input signal via the transmission line and a reference clock and generates a first clock signal. The voltage controlled oscillator receives the input signal via the transmission line and a control voltage from an internal node of the phase locked loop, and generates a clock signal. The phase selector receives the input signal via the transmission line and the clock signal from the voltage controlled oscillator, and generates a clock output signal. The D flip-flop receives the input signal via the transmission line and the clock output signal, and generates a data output signal.
    Type: Grant
    Filed: December 17, 2007
    Date of Patent: July 19, 2011
    Assignees: Mediatek Inc., National Taiwan University
    Inventors: Shen-Iuan Liu, Chih-Hung Lee, Lan-Chou Cho