Patents by Inventor Chih-Kuang Chen

Chih-Kuang Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11214868
    Abstract: The present disclosure provides a blocker plate, including a plate body having a plurality of through holes, a first zone from a center to a first radius of the plate body, having a first conductance, a second zone from the first radius to a second radius of the plate body, having a second conductance, a third zone from the second radius to a third radius of the plate body, having a third conductance, wherein the first radius is smaller than the second radius, the second radius is smaller than the third radius, and the second conductance is greater than the first conductance. A chemical vapor deposition (CVD) apparatus including the blocker plate is also disclosed.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: January 4, 2022
    Assignee: TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY LTD.
    Inventors: Huan-Chieh Chen, Chao-Chun Wang, Chih-Yu Wu, Keith Kuang-Kuo Koai
  • Patent number: 11011276
    Abstract: A method for establishing a computer-aided data interpretation model for immune diseases by immunomarkers and visualization is revealed. First combine a plurality of immunomarkers into an immunomarker panel. Then collect test data of a plurality of subjects measured by the immunomarker panel, and disease diagnosis information of the subjects for establishment of an immunomarker-panel testing database. Next new subjects are tested by the immunomarker panel. The data obtained and the corresponding information in the immunomarker-panel testing database are processed by unsupervised machine learning algorithm to get a computer-aided data interpretation model showing comparison of case distribution patterns. The method provides real-time analysis of multiple data to medical professionals for their reference. Thereby the correctness, the timeliness and the reproducibility of the interpretation result for the diagnosis and treatment of immune diseases are all improved.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: May 18, 2021
    Assignees: CHANG GUNG MEMORIAL HOSPITAL, LINKOU, CHANG GUNG UNIVERSITY
    Inventors: Chun-Hsien Chen, Yi-Ju Tseng, Hsin-Yao Wang, Wan-Ying Lin, Chih-Kuang Chen
  • Patent number: 10675260
    Abstract: A method for preventing or treating immunoinflammatory dermal disorders is provided. Also provided is a pharmaceutical composition for preventing or treating immunoinflammatory dermal disorders.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: June 9, 2020
    Assignee: TWi Biotechnology, Inc.
    Inventors: Po-Yuan Tseng, Wei-Shu Lu, Carl Oscar Brown, III, I-Yin Lin, III, Chen-En Tsai, Chih-Kuang Chen
  • Publication number: 20200013513
    Abstract: A method for establishing a computer-aided data interpretation model for immune diseases by immunomarkers and visualization is revealed. First combine a plurality of immunomarkers into an immunomarker panel. Then collect test data of a plurality of subjects measured by the immunomarker panel, and disease diagnosis information of the subjects for establishment of an immunomarker-panel testing database. Next new subjects are tested by the immunomarker panel. The data obtained and the corresponding information in the immunomarker-panel testing database are processed by unsupervised machine learning algorithm to get a computer-aided data interpretation model showing comparison of case distribution patterns. The method provides real-time analysis of multiple data to medical professionals for their reference. Thereby the correctness, the timeliness and the reproducibility of the interpretation result for the diagnosis and treatment of immune diseases are all improved.
    Type: Application
    Filed: July 9, 2018
    Publication date: January 9, 2020
    Applicants: CHANG GUNG MEMORIAL HOSPITAL, LINKOU, Chang Gung University
    Inventors: Chun-Hsien Chen, Yi-Ju Tseng, Hsin-Yao Wang, Wan-Ying Lin, Chih-Kuang Chen
  • Patent number: 10512625
    Abstract: A topical pharmaceutical composition containing diacerein and/or its analogs is provided. Also provided is a method for treating various diseases using this topical pharmaceutical composition.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: December 24, 2019
    Assignee: TWI BIOTECHNOLOGY, INC.
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • Publication number: 20190216368
    Abstract: A method of predicting daily living activities performance of a person with disabilities includes establishing a rehabilitation assessments panel based on a plurality of rehabilitation evaluation scales and laboratory data; evaluating a plurality of persons with disabilities by the rehabilitation assessments panel; entering assessment results and the corresponding activities of daily living (ADL) performance into a machine learning platform; utilizing variable selection methods to select a plurality of variables having optimal classification performance from the rehabilitation assessments panel; executing a machine learning algorithm to create an ADL prediction model based on the selected variables; evaluating a participant in terms of the rehabilitation assessments panel; and entering assessment results into the ADL prediction model for calculation, thereby obtaining a prediction result of future ADL performance for the participant.
    Type: Application
    Filed: January 13, 2018
    Publication date: July 18, 2019
    Applicants: CHANG GUNG MEMORIAL HOSPITAL, LINKOU, Chang Gung University
    Inventors: Chih-Kuang Chen, Chun-Hsien Chen, Hsin-Yao Wang, Wan-Ying Lin
  • Publication number: 20190105296
    Abstract: A topical pharmaceutical composition containing diacerein and/or its analogs is provided. Also provided is a method for treating various diseases using this topical pharmaceutical composition.
    Type: Application
    Filed: December 6, 2018
    Publication date: April 11, 2019
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • Patent number: 10213418
    Abstract: Uses of pharmaceutical compositions comprising berberine for treatment of dermatologic toxicities and other skin disorders.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: February 26, 2019
    Assignee: TWi Biotechnology, Inc.
    Inventors: Po-Yuan Tseng, Carol Oscar Brown, III, I-Yin Lin, Chen-En Tsai, Chih-Kuang Chen
  • Patent number: 10195170
    Abstract: Methods and compositions for inhibiting expression of ASC, expression of NLRP3, and/or formation of NLRP3 inflammasome complex by using diacerein or its analogs are provided. Also provided are methods and compositions for the treatment and/or prevention of a disorder mediated by ASC and/or NLRP3, and/or by formation of NLRP3 inflammasome complex by using diacerein or its analogs.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: February 5, 2019
    Assignee: TWI Biotechnology, Inc.
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • Patent number: 10154984
    Abstract: A topical pharmaceutical composition containing diacerein and/or its analogs is provided. Also provided is a method for treating various diseases using this topical pharmaceutical composition.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: December 18, 2018
    Assignee: TWi Biotechnology, Inc.
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • Publication number: 20180200235
    Abstract: A method for preventing or treating immunoinflammatory dermal disorders is provided.
    Type: Application
    Filed: January 19, 2018
    Publication date: July 19, 2018
    Inventors: Po-Yuan Tseng, Wei-Shu Lu, Carl Oscar Brown, III, I-Yin Lin, III, Chen-En Tsai, Chih-Kuang Chen
  • Publication number: 20180021290
    Abstract: A topical pharmaceutical composition containing diacerein and/or its analogs is provided. Also provided is a method for treating various diseases using this topical pharmaceutical composition.
    Type: Application
    Filed: July 25, 2017
    Publication date: January 25, 2018
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • Publication number: 20170319532
    Abstract: A method of treating and/or preventing blood-associated disorders is provided. Also provided is a method of treating and/or preventing hemophilic arthropathy and/or hemochromatosis arthropathy in a subject.
    Type: Application
    Filed: May 5, 2017
    Publication date: November 9, 2017
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • Patent number: 9744131
    Abstract: A topical pharmaceutical composition containing diacerein and/or its analogs is provided. Also provided is a method for treating various diseases using this topical pharmaceutical composition.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: August 29, 2017
    Assignee: TWi Biotechnology, Inc.
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • Publication number: 20170049733
    Abstract: Methods and compositions for inhibiting expression of ASC, expression of NLRP3, and/or formation of NLRP3 inflammasome complex by using diacerein or its analogs are provided. Also provided are methods and compositions for the treatment and/or prevention of a disorder mediated by ASC and/or NLRP3, and/or by formation of NLRP3 inflammasome complex by using diacerein or its analogs.
    Type: Application
    Filed: August 17, 2016
    Publication date: February 23, 2017
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • Publication number: 20170000732
    Abstract: A topical pharmaceutical composition containing diacerein and/or its analogs is provided. Also provided is a method for treating various diseases using this topical pharmaceutical composition.
    Type: Application
    Filed: June 30, 2016
    Publication date: January 5, 2017
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • Publication number: 20160303050
    Abstract: A controlled-release formulation containing diacerein or its analogs is provided. Also provided is a method of lowering blood levels of uric acid using this formulation.
    Type: Application
    Filed: April 20, 2015
    Publication date: October 20, 2016
    Inventors: Hanpin Lim, Carl Oscar Brown, III, Wei-Shu Lu, Tien-Kuen Chung, Chih-Kuang Chen
  • Patent number: 8865689
    Abstract: Methods and compositions for treating and/or preventing hyperuricemia or metabolic disorders associated with hyperuricemia comprising administering to a patient in need a therapeutically effective amount of diacerein, rhein, or a pharmaceutically acceptable salt, an analog, a prodrug, or an active metabolite thereof.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: October 21, 2014
    Assignee: TWi Biotechnology, Inc.
    Inventors: Mannching Sherry Ku, Chih-Kuang Chen, Wei-Shu Lu, I-Yin Lin
  • Patent number: 8846758
    Abstract: Methods for treating abnormal glycosylated hemoglobin (HbA1c) levels in a patient in need thereof, wherein the provided methods comprise administering to a patient in need a therapeutically effective amount of an Interleukin-1? modulator. Also, the invention provides compositions comprising at least one lipid modifying agent and an IL-1? modulator.
    Type: Grant
    Filed: July 19, 2012
    Date of Patent: September 30, 2014
    Assignee: TWi Biotechnology, Inc.
    Inventors: Mannching Sherry Ku, Chih-Kuang Chen, Wei-Shu Lu, Chih-Ming Chen, I-Yin Lin
  • Publication number: 20130022610
    Abstract: Methods for treating abnormal glycosylated hemoglobin (HbA1c) levels in a patient in need thereof, wherein the provided methods comprise administering to a patient in need a therapeutically effective amount of an Interleukin-1? modulator. Also, the invention provides compositions comprising at least one lipid modifying agent and an IL-1? modulator.
    Type: Application
    Filed: July 19, 2012
    Publication date: January 24, 2013
    Inventors: Mannching Sherry Ku, Chih-Kuang Chen, Wei-Shu Lu, Chih-Ming Chen, I-Yin Lin