Abstract: A device and method for improving light penetration is provided and applied to human tissues for biophotonics technology. When a laser beam penetrates a tissue inside a human body for biophotonics technology, ultrasounds generated by a high intensity focused ultrasound (HIFU) probe are focused to form an acoustic vortex around a forward path of the laser beam, causing the laser beam to pass through a central silent vortex action region of the acoustic vortex. A virtual optical waveguide is formed on surrounding tissues in the forward path of the laser beam through the acoustic vortex, to increase fluence of the laser beam through the acoustic vortex, and improve light penetration of the laser beam.

Abstract: A balloon catheter system assisted by ultrasound and microbubbles and a method for vasodilation are provided. The system includes: a controller; a sensor catheter; a highly focused ultrasound probe, and the highly focused ultrasound probe and the sensor catheter is connected to the controller; and a balloon catheter. The method of vasodilation includes: providing a sensor catheter into a blood vessel, and controlling a highly focused ultrasound probe to focus at a hardened portion of the blood vessel; removing the sensor catheter from the blood vessel and inserting a balloon catheter into the blood vessel; infusing microbubbles into the balloon catheter and controlling the highly focused ultrasound probe to start working to destroy a calcification point of the hardened portion of the blood vessel, and smoothly inflating the balloon catheter at the hardened portion of the blood vessel.

Abstract: The present invention provides a vortexed-acoustic-field method for creating cell permeability and opening blood-brain barrier, which comprises using an ultrasonic transducer; using a probe emitting a vortexed acoustic field, the probe emitting a vortexed acoustic field having a piezoelectric patch comprising at least one inner channel, where when there is a plurality of inner channels, a phase difference is generated between each two channels, which is used by the ultrasonic transducer to generate a vortex in an acoustic channel; and generating a vortexed acoustic field to enable the cells to have permeability, where the vortexed acoustic field has the following parameters: frequency: 20 kHz to 20 MHz, and acoustic pressure: 0.1 to 10 MPa.

Abstract: A vortex catheter thrombolytic system comprises an ultrasonic transducer; and a probe for transmitting a vortex acoustic field as well as a catheter, wherein the catheter is arranged in the probe for transmitting the vortex acoustic field, is connected to the ultrasonic transducer and is provided with a first inner channel and a second inner channel, the first inner channel is used for delivering drugs, and the second inner channel is used for vortex driving. A thrombolytic method comprises: performing an ultrasonic execution step through the vortex catheter thrombolytic system so as to generate an acoustic vortex; executing a focusing step so as to focus a drug delivery carrier to the center of the acoustic vortex; and executing a manipulation step so as to manipulate the drug delivery carrier to a lesion area.

Abstract: A method for normalizing blood vessels of lesions is disclosed, which includes administering an effective amount of oxygen-loaded microbubbles to a subject in need by intravenous injection, and projecting ultrasound from a ultrasonic emission device into the lesions for rupturing the oxygen-loaded microbubbles and releasing the oxygen to the lesions. Each of the oxygen-loaded microbubbles comprises oxygen and a water insoluble gas, and the particle size of microbubbles is 0.5˜20 ?m.

Abstract: The present invention provides imaging devices, systems, and methods of operation for acoustic-enhanced optical coherence tomography. The systems coordinate imaging devices, optical coherence tomography (OCT), and pulsed ultrasound (FUS) and or pulsed ultrasound (PUS) to enhance the contrast of images. Moreover, the systems improve in vivo diagnosis and drug release through the utilization of sonographic enhancers such as microbubbles (MBs).

Abstract: An ultrasound-sensing protein is disclosed, which is a mutant of Prestin in cochlear outer hair cells of non-sonar mammals. The mutant of Prestin has a substitution of serine for asparagine at position 308 and selectively has a substitution of threonine for asparagine at position 7.

Abstract: A method for normalizing blood vessels of lesions is disclosed, which includes administering an effective amount of oxygen-loaded microbubbles to a subject in need by intravenous injection, and projecting ultrasound from a ultrasonic emission device into the lesions for rupturing the oxygen-loaded microbubbles and releasing the oxygen to the lesions. Each of the oxygen-loaded microbubbles comprises oxygen and a water insoluble gas, and the particle size of microbubbles is 0.5˜20 ?m.

Abstract: The present invention provides an embodiment of an electronic device, including: an ultrasonic transmitting transducer, arranged to transmit a first ultrasonic signal, at a first time point, to an object to be tested at a first time point, wherein the first ultrasonic signal is reflected by the object to be tested to serve as a second ultrasonic signal; first, second and third ultrasonic receiving transducers, arranged to receive the second ultrasonic signal; and a processor, arranged to use Short-Time Fourier Transform to calculate a second time point, a third time point, and a fourth time point at which the first, second and third ultrasonic receiving transducers receive the second ultrasonic signal, and arranged to calculate the relative positions of the object to be tested and the ultrasonic transmitting transducer according to the second time point, the third time point, and the fourth time point.

Abstract: An ultrasonic device for transversely manipulating drug delivery carriers includes a driving unit and a transducer. The transducer is electrically connected to the driving unit and has a piezoelectric sheet in a curved shape. The piezoelectric sheet includes a plurality of channels, and a phase difference is generated between every two of the channels by the driving unit for producing an acoustic vortex.

Abstract: The present invention provides imaging devices, systems, and methods of operation for acoustic-enhanced optical coherence tomography. The systems coordinate imaging devices, optical coherence tomography (OCT), and pulsed ultrasound (FUS) and or pulsed ultrasound (PUS) to enhance the contrast of images. Moreover, the systems improve in vivo diagnosis and drug release through the utilization of sonographic enhancers such as microbubbles (MBs).

Abstract: An ultrasonic device for transversely manipulating drug delivery carriers includes a driving unit and a transducer. The transducer is electrically connected to the driving unit and has a piezoelectric sheet in a curved shape. The piezoelectric sheet includes a plurality of channels, and a phase difference is generated between every two of the channels by the driving unit for producing an acoustic vortex.

Abstract: The present invention provides an embodiment of an electronic device, including: an ultrasonic transmitting transducer, arranged to transmit a first ultrasonic signal, at a first time point, to an object to be tested at a first time point, wherein the first ultrasonic signal is reflected by the object to be tested to serve as a second ultrasonic signal; first, second and third ultrasonic receiving transducers, arranged to receive the second ultrasonic signal; and a processor, arranged to use Short-Time Fourier Transform to calculate a second time point, a third time point, and a fourth time point at which the first, second and third ultrasonic receiving transducers receive the second ultrasonic signal, and arranged to calculate the relative positions of the object to be tested and the ultrasonic transmitting transducer according to the second time point, the third time point, and the fourth time point.

Abstract: An imaging agent delivery method and system thereof are provided. The method includes applying an imaging agent to a region, and alternately performing a heating process and a detecting process to the region with an ultrasound transmitting device and an ultrasound receiving device, respectively. Subsequently, an ultrasound signal acquired is processed by the ultrasound receiving device to obtain a temperature image of the region and a vaporization image of the imaging agent, such that the performance of the imaging agent can be monitored on the basis of the temperature image and the vaporization image.

Abstract: The present invention provides a biomembrane phase-change droplet (PCD), including a hydrophobic liquid core; and a phospholipid-containing biomembrane encapsulating the hydrophobic liquid core, wherein the hydrophobic liquid core is vaporized by ultrasonic irradiation. The present disclosure also provides a drug carrier, including a biomembrane phase-change droplet; and a hydrophobic drug embedded on the biomembrane of the biomembrane phase-change droplet, wherein the hydrophobic drug is presented in an amount of 1-10 wt %, based on the weight of the drug carrier. The present invention further provides the use of aforementioned biomembrane phase-change droplet (PCD) and drug carrier.

Abstract: The present invention discloses a method for forming a nano-bubble. The forming method is different from the oil-water emulsion reaction in the prior art. The method comprises: taking an inorganic particle as a nucleus and performing a polymer coating process to coat at least one first polymer on the surface of the nucleus to form an organic/inorganic composite particle; then removing the nucleus of the organic/inorganic composite particle by way of the dissolution of a first solvent to form an impregnated nano-particle; performing a freeze-drying process to remove the first solvent to have the impregnated nano-particle form a hollow nano-particle; and finally dissolving the hollow nano-particle in a second solvent to form the nano-bubble.

Abstract: Since high-frequency ultrasound provides the advantage of high spatial resolution, it has been applied to relevant fields of medical imaging research. Due to a lack of high-frequency ultrasonic transducer with array structure, the high-frequency ultrasonic transducer must be performed in a fixed depth of focus during scanning. A swept scanning method is typical for flow estimation. However, this method cannot provide the precise flow estimation within the irregular-shaped object, because the focal zone of the above-mentioned transducer just covers a specific depth of focus and the outside the focal area corresponds poor signal to noise ratio. To resolve this problem, the present invention provides a skin scanning method, which can move the transducer along a scanning route parallel to the contour of the irregular-shaped object during scanning. The scanning results show that the skin scanning method improves the accuracy of flow estimation.

Abstract: The present invention discloses a method for forming a nano-bubble. The forming method is different from the oil-water emulsion reaction in the prior art. The method comprises: taking an inorganic particle as a nucleus and performing a polymer coating process to coat at least one first polymer on the surface of the nucleus to form an organic/inorganic composite particle; then removing the nucleus of the organic/inorganic composite particle by way of the dissolution of a first solvent to form an impregnated nano-particle; performing a freeze-drying process to remove the first solvent to have the impregnated nano-particle form a hollow nano-particle; and finally dissolving the hollow nano-particle in a second solvent to form the nano-bubble.

Abstract: A method and system for imaging a tissue having contrast agents dispersed therein by exciting nonlinear response of the contrast agents using dual-frequency ultrasound, including transmitting a dual-frequency ultrasound to a target zone having the contrast agents dispersed therein, both frequencies of the dual-frequency ultrasound being higher than a resonance frequency of the contrast agents, and a frequency difference between the frequencies of the dual-frequency ultrasound is within a predetermined range surrounding the resonance frequency of the contrast agents.