Abstract: Provided is a use of Wee1 kinase inhibitors in the treatment of cancer. In particular, provided is a use of Wee1 kinase inhibitors in the preparation of drugs for the treatment of cancers with Histone H3K27M mutation.

Abstract: The present invention relates to an LED structure having a progressive work function layer, which adopts a conversion layer with a gradually varying work function as the medium for forming an Ohmic contact between the p-type GaN and the metal reflection layer. The work function of the conversion layer is not a single value. Instead, different quantities of dopants are doped at different depths of the conversion layer. Thereby, the conversion layer can match excellently the connected p-type GaN and the metal reflection layer. By taking advantage of the high light transmissivity of the material of the conversion layer, the possibility that light is absorbed by the Ohmic contact layer is reduced. The conversion according to the present invention can also block diffusion of the metal in the metal reflection to the p-type GaN. Accordingly, it can be used as both an Ohmic contact layer and a barrier layer.

Abstract: An illumination apparatus includes a sunlight guide member, a light emitting device, a wavelength converting element, a fiber-optic light guide connecting the light emitting device and the wavelength converting element, and a lighting control system for controlling the light emitting diode. The sunlight guide member is provided to guide outdoor sunlight to an indoor area. The light emitting device is provided for generating light having a first wavelength range along a beam path. The wavelength converting element is disposed in the beam path and physically separated from the light emitting device. The wavelength converting element converts the light emitted by the light emitting device with the first wavelength range into light having a second wavelength range. The lighting control system is configured to detect an intensity of the outdoor sunlight and to control radiance of the light emitting device according to the detected intensity of the outdoor sunlight.

Abstract: The present invention relates to an LED structure having a progressive work function layer, which adopts a conversion layer with a gradually varying work function as the medium for forming an Ohmic contact between the p-type GaN and the metal reflection layer. The work function of the conversion layer is not a single value. Instead, different quantities of dopants are doped at different depths of the conversion layer. Thereby, the conversion layer can match excellently the connected p-type GaN and the metal reflection layer. By taking advantage of the high light transmissivity of the material of the conversion layer, the possibility that light is absorbed by the Ohmic contact layer is reduced. The conversion according to the present invention can also block diffusion of the metal in the metal reflection to the p-type GaN. Accordingly, it can be used as both an Ohmic contact layer and a barrier layer.