Patents by Inventor Chihiro TSUJI

Chihiro TSUJI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-O-sulfation enzyme mutant and 3-O-sulfation enzyme mutant, and method for using same
    Patent number: 11851688
    Abstract: The present invention provides a 2-OST mutant exhibiting a high activity.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: December 26, 2023
    Assignee: AJINOMOTO CO., INC.
    Inventors: Chihiro Tsuji, Tomoko Shimizu, Uno Tagami, Yasuhiro Mihara, Masayuki Sugiki, Shogo Nakano, Tomoharu Motoyama, Sohei Ito
  • Method for producing heparosan compound having isomerized hexuronic acid residue
    Patent number: 11639513
    Abstract: The present invention provides a method for producing a heparosan compound having an isomerized hexuronic acid residue and a method for producing a heparan sulfate with improved C5-epimerization efficiency.
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: May 2, 2023
    Assignee: AJINOMOTO CO., INC.
    Inventors: Chihiro Tsuji, Yasuhiro Mihara, Shogo Nakano, Tomoharu Motoyama, Souhei Ito
  • 2-O-Sulfation Enzyme Mutant and 3-O-Sulfation Enzyme Mutant, and Method for Using Same
    Publication number: 20230105158
    Abstract: The present invention provides a 2-OST mutant exhibiting a high activity.
    Type: Application
    Filed: November 18, 2022
    Publication date: April 6, 2023
    Applicant: AJINOMOTO CO., INC.
    Inventors: Chihiro Tsuji, Tomoko Shimizu, Uno Tagami, Yasuhiro Mihara, Masayuki Sugiki, Shogo Nakano, Tomoharu Motoyama, Sohei Ito
  • ANIMAL CELL CULTURING METHOD
    Publication number: 20230044979
    Abstract: A method for producing an objective protein by using animal cells as an expression host is provided. The objective protein is produced by culturing animal cells having an objective protein-producing ability in the presence of an L-cysteine derivative such as (2RS,4R)-2-methyl-2,4-thiazolidinedicarboxylic acid 2-ethyl ester.
    Type: Application
    Filed: September 13, 2022
    Publication date: February 9, 2023
    Applicant: AJINOMOTO CO., INC.
    Inventors: Seiichi Sato, Yuki Akeda, Yuta Endo, Ayana Matsuba, Chihiro Tsuji
  • 2-O-Sulfation Enzyme Mutant and 3-O-Sulfation Enzyme Mutant, and Method for Using Same
    Publication number: 20200181588
    Abstract: The present invention provides a 2-OST mutant exhibiting a high activity.
    Type: Application
    Filed: February 20, 2020
    Publication date: June 11, 2020
    Applicant: AJINOMOTO CO., INC.
    Inventors: Chihiro Tsuji, Tomoko Shimizu, Uno Tagami, Yasuhiro Mihara, Masayuki Sugiki, Shogo Nakano, Tomoharu Motoyama, Sohei Ito
  • Gamma glutamyl-valine synthase, and method for producing gamma glutamyl-valyl-glycine
    Patent number: 10508295
    Abstract: ?-Glu-Val synthetase suitable for generating ?-Glu-Val, and a method for producing ?-Glu-Val-Gly using the same are provided. By using ?-Glu-Val synthetase showing a ratio of ?-glutamylvaline synthetase activity to ?-glutamylglycine synthetase activity of 2.0 or higher, such as ?-Glu-Val synthetase of Kocuria rosea (AJ3132), ?-Glu-Val-Gly is produced from Glu, Val, and Gly as raw materials.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: December 17, 2019
    Assignee: AJINOMOTO CO., INC.
    Inventors: Chihiro Tsuji, Hiroyuki Nozaki
  • Method for Producing Heparosan Compound Having Isomerized Hexuronic Acid Residue
    Publication number: 20190338330
    Abstract: The present invention provides a method for producing a heparosan compound having an isomerized hexuronic acid residue and a method for producing a heparan sulfate with improved C5-epimerization efficiency.
    Type: Application
    Filed: July 18, 2019
    Publication date: November 7, 2019
    Applicant: AJINOMOTO CO., INC.
    Inventors: Chihiro Tsuji, Yasuhiro Mihara, Shogo Nakano, Tomoharu Motoyama, Souhei Ito
  • GAMMA-GLUTAMYL-VALINE SYNTHASE, AND METHOD FOR PRODUCING GAMMA-GLUTAMYL-VALYL-GLYCINE
    Publication number: 20160340707
    Abstract: ?-Glu-Val synthetase suitable for generating ?-Glu-Val, and a method for producing ?-Glu-Val-Gly using the same are provided. By using ?-Glu-Val synthetase showing a ratio of ?-glutamylvaline synthetase activity to ?-glutamylglycine synthetase activity of 2.0 or higher, such as ?-Glu-Val synthetase of Kocuria rosea (AJ3132), ?-Glu-Val-Gly is produced from Glu, Val, and Gly as raw materials.
    Type: Application
    Filed: August 11, 2016
    Publication date: November 24, 2016
    Applicant: AJINOMOTO CO., INC.
    Inventors: Chihiro TSUJI, Hiroyuki Nozaki