Abstract: A process parameter optimization method and system are provided. Key parameters are selected through a complex system response function to optimize a process, while also predicting an effect after process optimization. A large number of experiments due selection of factors and levels corresponding to the factors in the past experimental method may be greatly reduced, and a result may also be accurately predicted through a small number of experimental groups. Through the process parameter optimization method and system of the disclosure, the number of experiments may be reduced to save time and costs, so as to quickly find an optimal solution.

Abstract: A method for generating process parameters includes the following steps. Process parameters and upper limits and lower limits corresponding to the process parameters are established. Multiple sets of test parameters corresponding to the process parameters are established using an experimental planning method. Multiple optimization targets corresponding to the sets of test parameters are established using an experimental simulation method or using an experiment based on process design and the sets of test parameters. A set of optimized process parameters and an optimization target corresponding to the set of optimized process parameters are calculated using an optimization algorithm with the sets of test parameters as training parameters.

Abstract: A microwave plasma torch equipment includes a reaction chamber, a ventilation tube and a microwave source. The reaction chamber has a reaction area, a microwave inlet, a first divert channel, a second divert channel and a microwave diverter. Each of the first and second divert channels has first and second end parts. The first end parts are coupled to the microwave inlet. The second end parts are coupled to each other at the reaction area. The cross-sectional areas of the first end parts are greater than those of the second end parts. The microwave diverter is located at the junction of the microwave inlet and the first and second divert channels. The ventilation tube penetrates through the reaction area along a direction substantially perpendicular to the extending direction of the first and second divert channels. The microwave source is located at the microwave inlet and facing the microwave diverter.

Abstract: The present disclosure includes systems and methods for calculating a dosage of one or more medications. Some aspects include determining a dosage for a patient after an organ transplant, at least by determining a first dosage of a drug given to a patient on a first day, determining a first serum level of the patient associated with the first day, calculating a second dosage of the drug based on a first ratio between the first dosage and the first serum level, and generating a first output based on the second dosage. Some aspects include determining a fourth dosage of the drug based on: a second ratio between the second dosage and a second serum level and a third ratio between a third dosage and a third serum level. Some aspects include generating a second output based on the fourth dosage, the fourth dosage associated with a fourth time period.

Abstract: The art does not provide systematic and reproducible methods to personalize dosing of multiple immunosuppressive medications after transplantation. This invention provides a method to systematize multi-drug immuno suppression management in tissue and organ transplantation using an artificial intelligence-based complex systems approach. In embodiments of this invention, immunosuppression drug dose, blood drug concentrations, donor-derived fraction of cell free DNA (dd-cfDNA %), and aspartate aminotransferase are used to indicate allograft status or a proxy for allograft status, to generate a phenotypic response surface to produce individual treatment modalities and dosages using empirically determined unique coefficients. This surface is used to calculate appropriate immunosuppression drug doses associated with the desired outcome for that patient.

Abstract: An optimization method for a vacuum plating process includes following steps. A property of a thin film to be optimized is determined. According to the property of the thin film to be optimized, process parameters and a level of each of the process parameters are determined. M sets of experiments are designed, where M is a positive integer, M is positively related to a number of the process parameters, but M is not related to a number of the level of the process parameters. The M sets of experiments are performed to obtain M sets of test films and the property of each of the test films are measured or calculated. Process parameters used in the M sets of experiments and the property of the M sets of test films are fitted with a multi-dimensional quadratic transformation function to obtain a first fitting function. The first fitting function is dynamically modified using an iteration method to obtain a best fitting function.

Abstract: Systems and methods for artificial intelligence enable control of hemodynamics in an individual are provided. A number of embodiments use a phenotypic response surface (PRS) that describes a physiological response to a vasopressor and/or a vasodilator to guide administration of the vasopressor and/or vasodilator. Additional embodiments determine an individualized response to but not limited to a vasopressor and/or vasodilator based on the change in pressure to a dose based on a population-based average. Some embodiments continually update the PRS and/or individualized sensitivity based on changes in physiological response to the vasopressor and/or vasodilator.

Abstract: The invention provides a soluble honokiol derivative (such as a water soluble honokiol derivative) and its application in antagonizing glycoprotein VI receptor and providing antioxidant and neuroprotective effects.

Abstract: A method of optimising one or more physical properties of an alloy comprises conducting a plurality of trials per an experimental design on a plurality of candidate alloys. Each trial comprises measuring a plurality of values of each physical property of the candidate alloys for different values of a plurality of parameters, wherein the parameters comprise respective concentrations of the two or more constituents, and one or more process parameters. The method further comprises fitting the plurality of values of the physical property and the plurality of parameters to a response surface model; and determining, from the fitted response surface model, optimised values of the parameters that optimise the respective responses; wherein the response surface model describes a non-linear relationship between a time integral of each of the physical property and a linear combination of non-linear functions of the plurality of parameters.

Abstract: A method of determining optimal values of one or more process parameters for printing a part comprises obtaining a plurality of sets of test values for the one or more process parameters. An additive manufacturing system is caused to at least partially generate a plurality of test samples according to a design and the plurality of sets of test values. During or after generation of the plurality of test samples, test data indicative of respective measurements of at least one property of the test samples are obtained. The test data are fitted to a second-order function of the one or more process parameters to determine coefficients of the one or more process parameters. Based on the second-order function and the coefficients, optimal values are determined for the one or more process parameters that result in a global optimum for the at least one property.

Abstract: Systems and methods for artificial intelligence enable control of hemodyamics in an individual are provided. A number of embodiments use a phenotypic response surface (PRS) that describes a physiological response to a vasopressor and/or a vasodilator to guide administration of the vasopressor and/or vasodilator. Various embodiments continually update the PRS based on changes in physiological response to the vasopressor and/or vasodilator.

Abstract: Multiple tests of a complex system are conducted by applying varying combinations of input parameters from a pool of input parameters. Results of the tests are fitted into a model of the complex system by using multi-dimensional fitting. Using the model of the complex system, identification is made of at least one optimized combination of input parameters to yield a desired response of the complex system.

Abstract: The invention provides a soluble honokiol derivative (such as a water soluble honokiol derivative) and its application in antagonizing glycoprotein VI receptor and providing antioxidant and neuroprotective effects.

Abstract: A method includes: (1) applying stimulations to a system, wherein applying the stimulations includes modulating, over time, characteristics of the stimulations; (2) measuring a time-varying response of the system to the stimulations; (3) fitting the time-varying response of the system into a model of the system; and (4) using the model of the system, identifying an optimized combination of characteristics of the stimulations to yield a desired response of the system.

Abstract: The present invention is directed to methods of treating tuberculosis by providing a pharmaceutically effective amount of a combination of drug compounds.

Abstract: A semiconductor package structure is disclosed. The package structure includes a first substrate, a second substrate on which the first substrate is disposed, and a semiconductor chip which is disposed on the first substrate. The two substrates can include two notches or two solder receiving portions. Therefore, when the package structure is disposed on the printed circuit board (PCB), the package structure will protrude less on the surface of the printed circuit board (PCB); or, the solders on the printed circuit board (PCB) will not be shifted by the package structure.

Abstract: A semiconductor package structure is disclosed. The package structure includes a first substrate, a second substrate on which the first substrate is disposed, and a semiconductor chip which is disposed on the first substrate. The two substrates can include two notches or two solder receiving portions. Therefore, when the package structure is disposed on the printed circuit board (PCB), the package structure will protrude less on the surface of the printed circuit board (PCB); or, the solders on the printed circuit board (PCB) will not be shifted by the package structure.

Abstract: Disclosed are pharmaceutical compositions and methods of treating multiple myeloma by providing a pharmaceutically effective amount of each drug in a combination of drugs.

Abstract: An initial phenotypic map is derived for a patient subjected to an initial therapeutic regimen including a first drug, based on values of a therapeutic outcome for the patient and corresponding values of a dose of the first drug administered to the patient. Following a change from the initial therapeutic regimen to an updated therapeutic regimen, an updated value of the therapeutic outcome is received for the patient subjected to the updated therapeutic regimen. The initial phenotypic map is re-calibrated according to the updated value of the therapeutic outcome, and, using the re-calibrated phenotypic map, identification is made of a value of the dose of the first drug to be administered to the patient subjected to the updated therapeutic regimen.

Abstract: The invention provides a soluble honokiol detivative (such as a water soluble honokiol derivative) and its application in antagonizing glycoprotein VI receptor and providing antioxidant and neuroprotective effects.