Abstract: Methods and associated systems and apparatus for generating a three- dimensional (3D) flight path for a moveable platform such as an unmanned aerial vehicle (UAV) are disclosed herein. The method includes receiving a set of 3D information associated with a virtual reality environment and receiving a plurality of virtual locations in the virtual reality environment. For individual virtual locations, the system receives a corresponding action item. The system then generates a 3D path based on at least one of the set of 3D information, the plurality of virtual locations, and the plurality of action items. The system then generates a set of images associated with the 3D path and then visually presents the same to an operator via a virtual reality device. The system enables the operator to adjust the 3D path via the virtual reality device.

Abstract: The present invention relates to efficient processes useful in the preparation of fluorinated cyclic dinucleosides, such as [P(R)]-2?-deoxy-2?-fluoro-5?-O—[(R)-hydroxymercaptophosphinyl]-P-thio-?-D-arabino-adenylyl-(3??5?)-3?-deoxy-3?-fluoroguanosine cyclic nucleotide, which is also known as (2R,5R,7R,8S,10R,12aR,14R,15S,15aR,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-15,16-difluoro-2, 10-bis(sulfanyl)octahydro-2H,10H, 12H-2?5,10?5-5,8-methanofuro[3,2-1][1, 3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

Abstract: Methods and associated systems and apparatus for generating a three-dimensional (3D) flight path for a moveable platform such as an unmanned aerial vehicle (UAV) are disclosed herein. The method includes receiving a set of 3D information associated with a virtual reality environment and receiving a plurality of virtual locations in the virtual reality environment. For individual virtual locations, the system receives a corresponding action item. The system then generates a 3D path based on at least one of the set of 3D information, the plurality of virtual locations, and the plurality of action items. The system then generates a set of images associated with the 3D path and then visually presents the same to an operator via a virtual reality device. The system enables the operator to adjust the 3D path via the virtual reality device.

Abstract: The invention provides a Probiotic microcapsule and a preparation method thereof, relating to the technical field of Probiotic products. The method includes the following steps: (a) preparing a capsule core containing Probiotics: mixing the capsule core materials including Probiotic powder, microcrystalline cellulose and starch, then adding a hydroxypropyl methylcellulose solution thereinto, while mixing evenly, making the obtained mixture materials into spherical particulate capsule cores by the extrusion spherization method; (b) coating by atomization: coating the microcapsule cores with a coating material solution in a single layer or multiple layers by atomization, getting core-shell microcapsules. The Probiotic microcapsules prepared by the present invention have a large encapsulation, uniform microcapsule particles, controllable particle size, storage-resistance, targetability to intestinal tracts, resistance to gastric acids and high temperature stability.

Abstract: Evolved sortases exhibiting enhanced reaction kinetics and/or altered substrate preferences are provided herein, for example evolved sortases that bind recognitions motifs comprising a LMVGG [SEQ ID NO: 3] sequence. Also provided are methods (e.g., orthogonal transpeptidation and diagnostics methods) for using such sortases.

Abstract: A brake control device includes a housing, a brake lever, a hydraulic seat and a piston. The housing is formed of a plastic and includes a handlebar mounting portion at an end thereof that is mounted to a bicycle handlebar. The brake lever is pivotably connected to the housing at a pivot of the housing. The hydraulic seat is disposed within the housing and is distal from the handlebar mounting portion. The hydraulic seat is formed of a metal and defines a piston chamber and a hydraulic reservoir therein that are in fluid communication with each other. The piston is movably mounted to the piston chamber in the hydraulic seat, and is operably connected to the brake lever. The plastic of the housing is adhered to the hydraulic seat.

Abstract: The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.

Abstract: The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.

Abstract: Methods and associated systems and apparatus for generating a three-dimensional (3D) flight path for a moveable platform such as an unmanned aerial vehicle (UAV) are disclosed herein. The method includes receiving a set of 3D information associated with a virtual reality environment and receiving a plurality of virtual locations in the virtual reality environment. For individual virtual locations, the system receives a corresponding action item. The system then generates a 3D path based on at least one of the set of 3D information, the plurality of virtual locations, and the plurality of action items. The system then generates a set of images associated with the 3D path and then visually presents the same to an operator via a virtual reality device. The system enables the operator to adjust the 3D path via the virtual reality device.

Abstract: Methods and associated systems and apparatus for generating a three-dimensional (3D) flight path for a moveable platform such as an unmanned aerial vehicle (UAV) are disclosed herein. The method includes receiving a set of 3D information associated with a virtual reality environment and receiving a plurality of virtual locations in the virtual reality environment. For individual virtual locations, the system receives a corresponding action item. The system then generates a 3D path based on at least one of the set of 3D information, the plurality of virtual locations, and the plurality of action items. The system then generates a set of images associated with the 3D path and then visually presents the same to an operator via a virtual reality device. The system enables the operator to adjust the 3D path via the virtual reality device.

Abstract: A brake control device includes a housing, a brake lever, a hydraulic seat and a piston. The housing is formed of a plastic and includes a handlebar mounting portion at an end thereof that is mounted to a bicycle handlebar. The brake lever is pivotably connected to the housing at a pivot of the housing. The hydraulic seat is disposed within the housing and is distal from the handlebar mounting portion. The hydraulic seat is formed of a metal and defines a piston chamber and a hydraulic reservoir therein that are in fluid communication with each other. The piston is movably mounted to the piston chamber in the hydraulic seat, and is operably connected to the brake lever. The plastic of the housing is adhered to the hydraulic seat.

Abstract: The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.

Abstract: An electronic apparatus includes a base subassembly and a display subassembly. A hinge is rotatably coupled to the base subassembly and the display subassembly. The hinge allows the base subassembly and the display subassembly to rotate about an operating axis to change a rotational orientation of the display subassembly relative to the base subassembly. An elevation mechanism is operatively coupled to the hinge. The elevation mechanism includes a support tray disposed in the base subassembly that holds the mechanical elements. The elevation mechanism is responsive to torque that changes the rotational orientation of the display subassembly such that the elevation mechanism lifts the support tray when the display subassembly is moved to an upright position and lowers the support tray when the display subassembly is moved to a closed position.

Abstract: An electronic apparatus includes a base subassembly and a display subassembly. A hinge is rotatably coupled to the base subassembly and the display subassembly. The hinge allows the base subassembly and the display subassembly to rotate about an operating axis to change a rotational orientation of the display subassembly relative to the base subassembly. An elevation mechanism is operatively coupled to the hinge. The elevation mechanism includes a support tray disposed in the base subassembly that holds the mechanical elements. The elevation mechanism is responsive to torque that changes the rotational orientation of the display subassembly such that the elevation mechanism lifts the support tray when the display subassembly is moved to an upright position and lowers the support tray when the display subassembly is moved to a closed position.

Abstract: Methods and associated systems and apparatus for generating a three-dimensional (3D) flight path for a moveable platform such as an unmanned aerial vehicle (UAV) are disclosed herein. The method includes receiving a set of 3D information associated with a virtual reality environment and receiving a plurality of virtual locations in the virtual reality environment. For individual virtual locations, the system receives a corresponding action item. The system then generates a 3D path based on at least one of the set of 3D information, the plurality of virtual locations, and the plurality of action items. The system then generates a set of images associated with the 3D path and then visually presents the same to an operator via a virtual reality device. The system enables the operator to adjust the 3D path via the virtual reality device.

Abstract: The present invention is directed to irciniastatin analogs. Uses of these analogs also described.

Abstract: The present invention is directed to irciniastatin analogues. Uses of these analogues also described.