Patents by Inventor Chikahiko Eguchi
Chikahiko Eguchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5393890Abstract: A piperidine compound of the formula (I): ##STR1## wherein A is a fused aromatic ring; R is hydrogen, chloro or methoxy; X is (CH.sub.2).sub.n, which may be substituted, in which n is 0 or an integer of 1 to 10, --CH.dbd.CH--, --C.dbd.C--, --O--, --S--, --NH--, --N(COCH.sub.3)--, --N(COOC.sub.2 H.sub.5)--, --N(CHO)--, --N(CH.sub.3)--, --CO--, --SO--, or --SO.sub.2 --; Y is --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, --CH.sub.2 CO--, --O--, --S--, --NH--, --OCH.sub.2 --, --SCH.sub.2 --, --NHCH.sub.2 --, --CH(OH)CH.sub.2 -- or --CH(OH)CH(OH)--; and Q is substituted or unsubstituted n-hexyl, carboxypropyl, ethoxycarbonylpropyl, cyanopropyl, cyclohexyl, phenyl, indanyl, naphthyl, tetrahydronaphthyl, benzocycloheptyl, piperidinyl, tetrahydroisoquinolinyl, indolyl, pyrolyl, furyl, thienyl, thiazolyl, oxazolyl or N-methylpyrolyl, wherein any one or more of the --(CH.sub.2)-groups of the hexyl, carboxypropyl, ethoxycarbonylpropyl and cyanopropyl groups may be replaced by --CH.dbd.CH--, --C.dbd.Type: GrantFiled: July 1, 1994Date of Patent: February 28, 1995Assignee: Ajinomoto Co., Inc.Inventors: Masataka Syoji, Kozo Toyota, Chikahiko Eguchi, Ryoto Yoshimoto, Yoshikatsu Koyama, Hideki Domoto, Akira Kamimura
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Patent number: 5340718Abstract: Methods and polypeptides for assaying human proteins associated with Duchenne muscular dystrophy, are disclosed.Type: GrantFiled: January 27, 1993Date of Patent: August 23, 1994Assignee: Ajinomoto Co., Inc.Inventors: Tsuneo Ishiguro, Chikahiko Eguchi
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Patent number: 5250681Abstract: A piperidine compound of the formula (I): ##STR1## wherein A is a fused aromatic ring; R is hydrogen, chloro or methoxy; X is (CH.sub.2).sub.n, which may be substituted, in which n is 0 or an integer of 1 to 10, --CH.dbd.CH--, --C.dbd.C--, --O--, --S--, --NH--, --N(COCH.sub.3)--, --N(COOC.sub.2 H.sub.5)--, --N(CHO)--, --N(CH.sub.3)--, --CO--, --SO--, or --SO.sub.2 --; Y is --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, --CH.sub.2 CO--, --O--, --S--, --NH--, --OCH.sub.2 --, --SCH.sub.2 --, --NHCH.sub.2 --, --CH(OH)CH.sub.2 -- or --CH(OH)CH(OH)--; and Q is substituted or unsubstituted n-hexyl, carboxypropyl, ethoxycarbonylpropyl, cyanopropyl, cyclohexyl, phenyl, indanyl, naphthyl, tetrahydronaphthyl, benzocycloheptyl, piperidinyl, tetrahydroisoquinolinyl, indolyl, pyrolyl, furyl, thienyl, thiazolyl, oxazolyl or N-methylpyrolyl, wherein any one or more of the --(CH.sub.2)-groups of the hexyl, carboxypropyl, ethoxycarbonylpropyl and cyanopropyl groups may be replaced by --CH.dbd.CH--, --C.dbd.Type: GrantFiled: February 15, 1991Date of Patent: October 5, 1993Assignee: Ajinomoto Co., Inc.Inventors: Masataka Shoji, Kozo Toyota, Chikahiko Eguchi, Ryota Yoshimoto, Yoshikatsu Koyama, Hideki Domoto, Akira Kamimura
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Patent number: 5231105Abstract: An ethylamine derivative of formula (I): ##STR1## wherein A represents a carbon atom or a nitrogen atom;B represents a substituted or unsubstituted aralkyl or aryl group;C represents hydrogen, alkyl, aralkyl, or aryl, each of which may optionally be substituted orC may optionally be bonded to A to form an alkylene bridge which is optionally substituted,Q represents a substituted or unsubstituted aryl group, said group optionally being substituted by hetero atom(s) or substituent(s) optionally containing hetero atom(s); andX represents an alkylene bridge having from 2 to 20 carbon atoms and is optionally substituted with groups which include hetero atoms with the non-hetero atom substituents optionally containing hetero atoms.Type: GrantFiled: May 22, 1989Date of Patent: July 27, 1993Assignee: Ajinomoto Co., Inc.Inventors: Masataka Shoji, Kozo Toyota, Chikahiko Eguchi, Ryota Yoshimoto, Yosikatsu Koyama, Hideki Domoto, Akira Kamimura
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Patent number: 5229400Abstract: A piperidine derivative of general formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein ##STR2## is any of several specified aromatic-containing groups; X is selected from one of several hetero atom-containing groups or C.sub.Type: GrantFiled: October 4, 1991Date of Patent: July 20, 1993Assignee: Ajinomoto Co., Inc.Inventors: Akira Hirasawa, Masataka Shoji, Ryota Yoshimoto, Yuichi Gyotoku, Chikahiko Eguchi
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Patent number: 5216172Abstract: Agents against drug-resistant tumor cells comprising a 1,4-dihydropyridine derivative represented by the following formula (I): ##STR1## wherein R.sup.1 is an aryl group which may be substituted;R.sup.2 and R.sup.3, which may be the same or different, each is a member selected from the group consisting of an alkyl group, an alkyloxycarbonyl group, an aryloxycarbonyl group, an aralkyloxycarbonyl group, an aminocarbonyl group, a hydroxycarbonyl group, a formyl group, and a cyano group, each of which may be substituted;R.sup.4 and R.sup.5 is a hydrogen atom or a member selected from the group consisting of a lower alkyl group, a hydroxymethyl group, a cyano group, an amino group, a formyl group, and a halogen atom; andR.sup.Type: GrantFiled: January 28, 1991Date of Patent: June 1, 1993Assignees: Ajinomoto Co., Inc., Japanese Foundation for Cancer ResearchInventors: Kouzou Toyota, Hisashi Shinkai, Hirozumi Eto, Akira Kamimura, Chikahiko Eguchi, Koji Ohsumi, Takashi Tsuruo
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Patent number: 4971993Abstract: There are disclosed dipeptide derivatives represented by the general formula: ##STR1## wherein R.sup.1 is a radical selected from the group consisting of alkyl, aralkyl and aryl groups optionally containing one or more substituent groups, R.sup.2 is a radical selected from the group consisting of hydrogen atoms and alkyl, aralkyl and aryl groups optionally containing one or more substituent groups, R.sup.3 is a radical selected from the group consisting of hydrogen atoms and alkyl, aralkyl and aryl groups optionally containing one or more substituent groups, R.sup.4 is a radical selected from the group consisting of hydrogen atoms and alkyl, aralkyl and aryl groups optionally containing one or more substituent groups, and R.sup.Type: GrantFiled: September 1, 1988Date of Patent: November 20, 1990Assignee: Ajinomoto Co., Inc.Inventors: Masahiko Kurauchi, Chikahiko Eguchi, Shigebumi Hashimoto
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Patent number: 4719200Abstract: An amino acid derivative having anti-hypertensive activity and having the formula: ##STR1## wherein one of X or Y represents an acyl group RCO--, and wherein R is an amino acid residue selected from the group consisting of glycyl, alanyl, valyl, leucyl, isoleucyl, phenylalanyl, methionyl, prolyl, ceryl, threonyl, arginyl, lysyl, histidyl, aspartyl, asparaginyl, tyrosyl, cysteinyl, tryptophyl, and hydroxyprolyl, and the other group is H; R.sup.1 and R.sup.2 are the same or different from each other, and each represents H, lower alkyl having 1 to 6 carbon atoms, aryl having 6 to 12 carbon atoms, any of which are unsubstituted or substituted by one or more lower alkyl, lower alkoxy, hydroxy, amino, carboxy or mercapto groups; Z represents --OH, RO--, RS--, RNH--, NONH--, RONH--, RSO.sub.Type: GrantFiled: August 26, 1985Date of Patent: January 12, 1988Assignee: Ajinomoto Co., Inc.Inventors: Chikahiko Eguchi, Masahiko Kurauchi, Shumpei Sakakibara
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Patent number: 4618695Abstract: A method of preparing .alpha.-L-phenylalanine methyl ester and its hydrochloride, which comprises dissolving .alpha.-L-aspartyl-L-phenylalanine .beta.-methyl ester in a methanol/hydrochloric acid mixture solvent which contains, when hydrochloric acid is expressed in terms of concentrated hydrochloric acid and water, 0 to 20% by volume of methanol, 8 to 55% by volume of concentrated hydrochloric acid and water (balance) in a concentration from 0.01 mol/dl to 0.3 mol/dl; holding the solution at 0.degree. to 60.degree. C. to effect intramolecular ester exchange reaction and crystallize out the formed .alpha.-L-aspartyl-L-phenylalanine methyl ester as its hydrochloride; isolating the hydrochloride; and obtaining, when required, the free ester by neutralization with an alkali, is disclosed.Type: GrantFiled: May 17, 1984Date of Patent: October 21, 1986Assignee: Ajinomoto Co., Inc.Inventors: Yoichi Ozawa, Shinichi Kishimoto, Emiko Shinohara, Tadashi Takemoto, Chikahiko Eguchi
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Patent number: 4606854Abstract: A method for preparing .alpha.-L-aspartyl-L-phenylalanine methyl ester and its hydrochloride which comprises dissolving .alpha.-L-aspartyl-L-phenylalanine dimethyl ester in a mixture of 0-10% (v/v) methanol, 8-55% (v/v) of concentrated hydrochloric acid, and water (remainder) to a concentration of 0.01 mol/dl to 0.30 mol/dl; holding the resulting solution at one or more temperatures between 0.degree. and 60.degree. C. for a time sufficient for crystals of .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride to precipitate out, and isolating the crystals. The hydrochloride may then be treated with alkali to yield .alpha.-L-aspartyl-L-phenylalanine methyl ester.Type: GrantFiled: May 17, 1984Date of Patent: August 19, 1986Assignee: Ajinomoto Co., Inc.Inventors: Yoichi Ozawa, Shinichi Kishimoto, Emiko Shinohara, Tadashi Takemoto, Chikahiko Eguchi
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Patent number: 4387232Abstract: A new process is disclosed for preparing N-acylcarnosine which comprises reacting histidine with 3-acylaminopropionic acid reactive derivatives under basic conditions, and 3-acylaminopropionic acid reactive derivative being acid chloride, mixed acid anhydride salt with sulfuric acid, mixed acid anhydride with mono alkyl carbonate or mixed acid anhydride with phosphoric acid derivatives.Type: GrantFiled: December 9, 1981Date of Patent: June 7, 1983Assignee: Ajinomoto Company IncorporatedInventors: Chikahiko Eguchi, Fusayoshi Kakizaki, Hirozumi Eto
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Patent number: 4361560Abstract: An imidazoledicarboxylic acid derivative having the following formula: ##STR1## wherein X is a group selected from the group consisting of hydrogen atom and hydroxyl group. The compounds are useful as antibiotics.Type: GrantFiled: September 16, 1980Date of Patent: November 30, 1982Assignee: Ajinomoto Company IncorporatedInventors: Naohiko Yasuda, Chikahiko Eguchi, Masaru Okutsu, Yoshiteru Hirose
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Patent number: 4217450Abstract: Compounds having the following formula: ##STR1## wherein X is a radical selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, methyl and amino.Y is a radical selected from the group consisting of hydrogen and hydroxy, andA is an organic compound residue selected from the group consisting of having the formula: ##STR2## wherein Z is a radical selected from the group consisting hydrogen, acyloxy, carbamoyloxy, (heteroaromatic) thio, pyridinium, quinolinium and picolinium; and salts thereof, are useful as anti-bacterial agents active against Pseudomonas aeruginosa.Type: GrantFiled: June 7, 1978Date of Patent: August 12, 1980Assignee: Ajinomoto Company, IncorporatedInventors: Naohiko Yasuda, Chikahiko Eguchi, Masaru Okutsu, Yoshiteru Hirose
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Patent number: 4211840Abstract: D-.alpha.-amino acids are produced by contacting a 5-substituted hydantoin with an effective amount of an enzyme capable of converting the 5-substituted hydantoin to the D-.alpha.-amino acid produced by a microorganism in an aqueous medium at a pH in the range of 4 to 9, the microorganism being capable of utilizing the D-isomer of the 5-substituted hydantoin as the sole nitrogen source, but substantially incapable of utilizing the L-isomer of the 5-substituted hydantoin as the nitrogen source and the substituent of the 5-position being such that upon reaction with the enzyme, an optically active D-.alpha.-amino acid isomer is produced; and recovering the D-.alpha.-amino acid which accumulates in the aqueous medium.Type: GrantFiled: April 17, 1978Date of Patent: July 8, 1980Assignee: Ajinomoto Company, IncorporatedInventors: Shigeru Nakamori, Kenzo Yokozeki, Koji Mitsugi, Chikahiko Eguchi, Hisao Iwagami
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Patent number: 4016037Abstract: L-amino acids are produced by fermenting a hydantoin compound with Flavobacterium aminogenes or its enzymes.Type: GrantFiled: October 15, 1975Date of Patent: April 5, 1977Assignee: Ajinomoto Co., Inc.Inventors: Koji Mitsugi, Konosuke Sano, Kenzo Yokozeki, Kazuhiko Yamada, Ichiro Noda, Teruhiko Kagawa, Chikahiko Eguchi, Naohiko Yasuda, Fumihide Tamura, Kazushi Togo
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Patent number: RE38257Abstract: A piperidine compound of the formula (I): wherein A is a fused aromatic ring; R is hydrogen, chloro or methoxy; X is (CH2)n, which may be substituted, in which n is 0 or an integer of 1 to 10, —CH≡CH—, —C≡C—, —O—, —S—, —NH—, —N(COCH3)—, —N(COOC2H5)—, —N(CHO)—, —N(CH3)—, —CO—, —SO—, or —SO2—; Y is —CH≡CH—, —CH2CH2—, —CH2CO—, —O—, —S—, —NH—, —OCH2—, —SCH2—, —NHCH2—, —CH(OH)CH2— or —CH(OH)CH(OH)—; and Q is substituted or unsubstituted n-hexyl, carboxypropyl, ethoxycarbonylpropyl, cyanopropyl, cyclohexyl, phenyl, indanyl, naphthyl, tetrahydronaphthyl, benzocycloheptyl, piperidinyl, tetrahydroisoquinolinyl, indolyl, pyrolyl, furyl, thienyl, thiazolyl, oxazolyl or N-methylpyrolyl, wherein any one or more of tType: GrantFiled: February 10, 1999Date of Patent: September 23, 2003Assignee: Ajinomoto Co., Inc.Inventors: Masataka Shoji, Kozo Toyota, Chikahiko Eguchi, Ryota Yoshimoto, Yoshikatsu Koyama, Hideki Domoto, Akira Kamimura