Patents by Inventor Chikao Yoshikumi

Chikao Yoshikumi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5089481
    Abstract: Disclosed herein are polysaccharides extracted from marine algae and an antiviral drug containing as active ingredient polysaccharides extracted from seaweeds.
    Type: Grant
    Filed: November 15, 1990
    Date of Patent: February 18, 1992
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Shigeaki Muto, Koichi Niimura, Minoru Oohara, Yoshiharu Oguchi, Kenichi Matsunaga, Kunitaka Hirose, Junji Kakuchi, Norifumi Sugita, Takao Furusho, Chikao Yoshikumi, Masaaki Takahashi
  • Patent number: 5008243
    Abstract: Disclosed herein is a pharmaceutical composition having antirheumatic activity, antithrombotic activity, analgetic activity, antipyretics activity, anti-hyperlipemic activity and anti-inflammatory activity and activities of reducing the level of blood sugar, raising the coronary blood flow, improving the capability of deformation of erythrocytes, reducing the blood pressure, ameliorating proteinuria and proteinemia and regulating production or metabolism of prostaglandins in a mammal in dosage unit form, which comprises a dosage effective to produce said activities of a glycoprotein having a molecular weight of 5000 to 300,000 as determined by ultracentrifugal method and about 18 to 38% by weight of proteins, produced by culturing a basidiomycetous fungal species belonging to the genus Coriolus, extracting the thus proliferated mycelia or fruit bodies with hot water or aqueous alkali solution and removing low molecular weight substances having a molecular weight of less than 5000 from the extract.
    Type: Grant
    Filed: December 16, 1988
    Date of Patent: April 16, 1991
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Masanori Ikuzawa, Yoshiharu Oguchi, Kenichi Matsunaga, Noriyuki Toyoda, Takao Furusho, Takayoshi Fujii, Chikao Yoshikumi
  • Patent number: 5001118
    Abstract: Disclosed herein is a method for preventing senescence and increasing bone mass namely, bone volume and bone strength which method comprises administering 24,25-dihydroxy cholecalciferol in a pharmaceutically effective amount, and also use of 24,25-dihydroxy cholecalciferol for preparing anti-senescent compositions and compositions for increasing bone mass.
    Type: Grant
    Filed: December 10, 1987
    Date of Patent: March 19, 1991
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Yuji Maeda, Hideyuki Yamato, Toru Hirai, Masanori Ikuzawa, Mikio Matsuki, Masanori Togawa, Eiji Inoguchi, Sinji Nakajima, Tadaaki Kato, Chikao Yoshikumi
  • Patent number: 4985543
    Abstract: Disclosed herein are lectins extracted form a plant of the class Dicotyledoneae and an antiretoviral drug comprising as an active ingredient an effective amount of the lectins.
    Type: Grant
    Filed: June 17, 1988
    Date of Patent: January 15, 1991
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Norifumi Sugita, Koichi Niimura, Yoshiharu Oguchi, Kunitaka Hirose, Kenichi Matsunaga, Minoru Oohara, Shigeaki Muto, Junji Kakuchi, Takao Furusho, Chikao Yoshikumi, Masaaki Takahashi
  • Patent number: 4957906
    Abstract: Disclosed is a pharmaceutical composition containing an aminobenzoic acid derivative as an active ingredient represented by the following general formula: ##STR1## wherein .sup.1 R donotes one member selected from the group consisting of the residual groups formed by removing OH at 1(alpha) or 1(beta) position from arabinose, glucose, galactose and mannose, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 26, 1988
    Date of Patent: September 18, 1990
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Chikao Yoshikumi, Yoshio Ohmura, Fumio Hirose, Masanori Ikuzawa, Kenichi Matsunaga, Takayoshi Fujii, Minoru Ohhara, Takao Ando
  • Patent number: 4925662
    Abstract: Disclosed herein are an anti-tumor substance obtained by bonding an anti-tumor agent to human immunoglobulin, and a process for producing the same.
    Type: Grant
    Filed: January 14, 1988
    Date of Patent: May 15, 1990
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Yoshiharu Oguchi, Koichi Niimura, Takayoshi Fujii, Masahiko Fujii, Kenichi Matsunaga, Chikao Yoshikumi
  • Patent number: 4874750
    Abstract: Disclosed is a pharmaceutical composition containing an aminobenzoic acid derivative as an active ingredient represented by the following general formula: ##STR1## wherein .sup.1 R donotes one member selected from the group consisting of the residual groups formed by removing OH at 1(alpha) or 1(beta) position from arabinose, glucose, galactose and mannose, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 17, 1986
    Date of Patent: October 17, 1989
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Chikao Yoshikumi, Yoshio Ohmura, Fumio Hirose, Masanori Ikuzawa, Kenichi Matsunaga, Takayoshi Fujii, Minoru Ohhara, Takao Ando
  • Patent number: 4866047
    Abstract: Disclosed herein is a method for inhibiting the formation of urinary calculus by the administration of 24,25-dihydroxycholecarciferol.
    Type: Grant
    Filed: October 1, 1987
    Date of Patent: September 12, 1989
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Hideyuki Yamato, Yuji Maeda, Takayoshi Fujii, Yasuhiko Kobayashi, Kenichi Saito, Fumio Hirose, Tadaaki Kato, Chikao Yoshikumi
  • Patent number: 4851395
    Abstract: Disclosed is nitrogen-containing polysaccharide substantially free of units having a molecular weight below about 5,000, said nitrogen-containing polysaccharide having been extracted from Coriolus versicolor (Fr.) Quel., substantially all polymer units having a molecular weight below about 5,000 having been removed therefrom, which exhibits antitumor and immunological activity.
    Type: Grant
    Filed: February 26, 1988
    Date of Patent: July 25, 1989
    Assignee: Kureha Kagaku Kogyo Kabushiki Kausha
    Inventors: Saburo Ueno, Chikao Yoshikumi, Yoshio Omura, Takayoshi Fujii, Toshihiko Wada, Eiichi Takahashi, Fumio Hirose
  • Patent number: 4820689
    Abstract: Disclosed herein is a pharmaceutical composition having antirheumatic activity, antithrombotic activity, analgetic activity, antipyretic activity, anti-hyperlipemic activity and anti-inflammatory activity and activities of reducing the level of blood sugar, raising the coronary blood flow, improving the capability of deformation of erythrocytes, reducing the blood pressure, ameliorating proteinuria and proteinemia and regulating production or metabolism of prostaglandins in a mammal in dosage unit form, which comprises a dosage effective to produce said activities of a glycoprotein having a molecular weight of 5000 to 300000 as determined by ultracentrifugal method and about 18 to 38% by weight of proteins, produced by culturing a basidiomycetous fungal species belonging to the genus Coriolus, extracting the thus proliferated mycelia or fruit bodies with hot water or aqueous alkali solution and removing low molecular weight substances having a molecular weight of less than 5000 from the extract.
    Type: Grant
    Filed: August 22, 1986
    Date of Patent: April 11, 1989
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Masanori Ikuzawa, Yoshiharu Oguchi, Kenichi Matsunaga, Noriyuki Toyoda, Takao Furusho, Takayoshi Fujii, Chikao Yoshikumi
  • Patent number: 4801581
    Abstract: Disclosed is a pharmaceutical composition containing p-aminobenzoic acid-N-D-xyloside or a pharmaceutically a acceptable salt thereof as an active ingredient.
    Type: Grant
    Filed: March 22, 1985
    Date of Patent: January 31, 1989
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Chikao Yoshikumi, Yoshio Ohmura, Fumio Hirose, Masanori Ikuzawa, Kenichi Matsunaga, Takayoshi Fujii, Minoru Ohara, Takao Ando
  • Patent number: 4783419
    Abstract: Disclosed herein is a method for examining cells, comprising subjecting the cells to an antigen-antibody reaction treatment, then measuring a pattern of the electrophoretic mobility of the cells and comparing the electrophoretic property of the cells under examination with the electrophoretic property of standard cells.
    Type: Grant
    Filed: March 21, 1985
    Date of Patent: November 8, 1988
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Haruhisa Hayashi, Yoshiharu Oguchi, Kenichi Matsunaga, Chikao Yoshikumi
  • Patent number: 4758558
    Abstract: Disclosed herein are the derivatives of substituted cephalosporanic acid represented by the formula (I): ##STR1## wherein R.sup.1 represents a 4-pyridylthiomethyl group, an alpha-aminobenzyl group, a cyanomethyl group or a 1-tetrazolylmethyl group; R.sup.2 represents a hydrogen atom, an acetoxy group or a (5-methyl-1,3,4-thiadiazol-2-yl)thio group; R.sup.3 represents a hydrogen atom, a hydroxyl group, a carbamoyl group, an alkyl group having 1 to 4 carbon atoms or --(CONH).sub.m (CH.sub.2).sub.n --COOH wherein m is 0 or 1, n is 0, 1 or 2 and the carboxyl group may have been converted to a salt or an ester thereof; p is 0, 1 or 2 and X represents carbon atom or nitrogen atom, and antibiotics comprising the derivatives of substituted cephalosporanic acid represented by the formula (I).
    Type: Grant
    Filed: May 19, 1986
    Date of Patent: July 19, 1988
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Akihiko Kanno, Shigeaki Muto, Koichi Niimura, Takao Ando, Takayoshi Fujii, Masahiko Fujii, Takao Furusho, Chikao Yoshikumi
  • Patent number: 4757054
    Abstract: Disclosed is a pharmaceutical composition containing p-aminobenzoic acid-N-D-xyloside or a pharmaceutically a acceptable salt thereof as an active ingredient.
    Type: Grant
    Filed: January 7, 1987
    Date of Patent: July 12, 1988
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Chikao Yoshikumi, Yoshio Ohmura, Fumio Hirose, Masanori Ikuzawa, Kenichi Matsunaga, Takayoshi Fujii, Minoru Ohara, Takao Ando
  • Patent number: 4748159
    Abstract: Disclosed is a method for the treatment of hyperglycemia, hyperlipemia, inflammatory diseases, pains due to the accentuation of central nerve, pyrexia due to the accentuation of central nerve or tumor, which comprises administering to a patient suffering therefrom a pharmaceutically effective amount of p-aminobenzoic acid-N-L-rhamnoside or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 24, 1986
    Date of Patent: May 31, 1988
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Chikao Yoshikumi, Yoshio Ohmura, Fumio Hirose, Masanori Ikuzawa, Kenichi Matsunaga, Takayoshi Fujii, Minoru Ohhara, Takao Ando
  • Patent number: 4738843
    Abstract: Disclosed herein are an anti-tumor substance obtained by bonding an anti-tumor agent to human immunoglobulin, and a process for producing the same.
    Type: Grant
    Filed: January 20, 1987
    Date of Patent: April 19, 1988
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Yoshiharu Oguchi, Koichi Niimura, Takayoshi Fujii, Masahiko Fujii, Kenichi Matsunaga, Chikao Yoshikumi
  • Patent number: 4734409
    Abstract: Disclosed herein are a cephalosporin derivative represented by the formula (I): ##STR1## wherein R.sup.1 represents a halogenoalkyl group, a salt and ester thereof, a process for producing the same, and a pharmaceutical composition and an antibacterial agent comprising the same.
    Type: Grant
    Filed: February 15, 1985
    Date of Patent: March 29, 1988
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Shigeaki Muto, Chikao Yoshikumi, Takao Furusho, Isamu Motokawa, Yoko Onishi, Akihiko Kanno, Takayoshi Fujii, Takao Ando
  • Patent number: 4708950
    Abstract: Disclosed is a pharmaceutical composition containing an aminobenzoic acid derivative as an active ingredient represented by the following general formula: ##STR1## wherein .sup.1 R denotes one member selected from the group consisting of the residual groups formed by removing OH at 1(alpha) or 1(beta) position from arabinose, xylose, glucose, galactose, rhamnose and mannose, and .sup.2 R denotes hydrogen or methyl group, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 27, 1984
    Date of Patent: November 24, 1987
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Chikao Yoshikumi, Yoshio Ohmura, Fumio Hirose, Masanori Ikuzawa, Kenichi Matsunaga, Takayoshi Fujii, Minoru Ohhara, Takao Ando
  • Patent number: 4699787
    Abstract: A method of restoring the immune response of a patient having a lowered immune response level is provided, in which the patient is given an effective amount of certain nitrogen-containing polysaccharides derived from Coriolus versicolor (Fr.) Quel, where the polymer units having a molecular weight of below about 5,000 have been removed therefrom.
    Type: Grant
    Filed: March 6, 1984
    Date of Patent: October 13, 1987
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Saburo Ueno, Chikao Yoshikumi, Yoshio Omura, Takayoshi Fujii, Toshihiko Wada, Eiichi Takahashi, Fumio Hirose
  • Patent number: 4690920
    Abstract: Disclosed herein are a derivative of a substituted cephalosporanic acid, represented by the formula (I): ##STR1## wherein p is 0, 1 or 2 and R.sup.1 represents a hydrogen atom, a hydroxyl group, a carbamoyl group, an alkyl group having 1 to 4 carbon atoms or --(CONH).sub.m (CH.sub.2).sub.n --COOH wherein m is 0 or 1; n is 0, 1 or 2 and the carboxyl group may have been converted to the salt or the ester thereof, and an antibiotic comprising a derivative of substituted cephalosporanic acid represented by the formula (I).
    Type: Grant
    Filed: December 20, 1983
    Date of Patent: September 1, 1987
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Akihiko Kanno, Shigeaki Muto, Koichi Niimura, Takao Ando, Takayoshi Fujii, Masahiko Fujii, Takao Furusho, Chikao Yoshikumi