Abstract: An object of the present invention is to ensure rigid formation of the folds of the protrusions of the paper sheet and smooth conveyance of the folding-processed paper sheet to the downstream side of the folding position in the paper conveyance direction without causing the problems such as jamming. A folding unit includes a lower guide plate arranged at a position facing a folding plate at the folding position, and an arrangement position of a turning shaft of the folding plate is vertically movable with respect to the lower guide plate.

Abstract: A paper folding device that folds a planar paper sheet while conveying the paper sheet along a paper sheet conveyance surface includes a pair of first conveyance rollers disposed on an upstream side in a paper sheet conveyance direction, a pair of second conveyance rollers disposed on a downstream side in the paper sheet conveyance direction, a switching gate plate installed on the paper sheet conveyance surface between both pairs of the rollers, a folding plate disposed above the switching gate plate, and a control unit that controls an operation of an entire device.

Abstract: The invention relates to a process for producing 1.alpha.-hydroxydehydroepiandrosterone by fermenting or reacting dehydroepiandrosterone or a derivative thereof with microorganisms of the species Penicillium oxalicum or Aspergillus terreus or mycelium or extracts therefrom obtained when the microorganisms are in a stationary phase of growth. The invention process produces steroid compounds which are pharmacologically valuable substances.

Abstract: The invention relates to a process for producing 7.sub..alpha. -hydroxylated steroids by fermenting or reacting a steroid to be hydroxylated with microorganisms of the genus Botryodiplodia or enzyme extracts thereof until hydroxylation occurs. The invention process produces steroid compounds which are pharmacologically valuable substances.

Abstract: A fermentation process for the preparation of 7.alpha.-hydroxylated steroids utilizing strains of the genus Mucor is disclosed. The 7.alpha.-hydroxylated steroids are useful intermediates for the synthesis of chenodeoxycholic acid as well as steroidal hormones.