Patents by Inventor Chin-Chean Wong

Chin-Chean Wong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method to restore cartilaginous phenotype of chondrocytes after cultured and expanded in vitro
    Patent number: 8431399
    Abstract: The present invention provides a method for restoring native chondrocyte phenotype and functions of, and/or increasing type II collagen as well as aggrecan mRNA expression levels and GAG accumulation level in dedifferentiated chondrocytes which have been subcultured and expanded in vitro, which comprising culturing the said dedifferentiated chondrocytes in vitro with a medium comprising type II collagen, or its biologically active peptide fragment(s) or analogs with or without growth factor(s), wherein the type II collagen or its biologically active peptide fragment(s) or analogs are effective to restore chondrocyte phenotype and functions of, and/or to increase type II collagen and aggrecan expression levels and GAG accumulation level in the said dedifferentiated chondrocytes.
    Type: Grant
    Filed: March 2, 2010
    Date of Patent: April 30, 2013
    Assignee: Taipei Medical University
    Inventors: Yu-Hui Tsai, Li-Hsuan Chiu, Chin-Chean Wong, Wen-Fu Lai, Shih-Ching Chen
  • METHOD TO RESTORE CARTILAGINOUS PHENOTYPE OF CHONDROCYTES AFTER CULTURED AND EXPANDED IN VITRO
    Publication number: 20110217773
    Abstract: The present invention provides a method for restoring native chondrocyte phenotype and functions of, and/or increasing type II collagen as well as aggrecan mRNA expression levels and GAG accumulation level in dedifferentiated chondrocytes which have been subcultured and expanded in vitro, which comprising culturing the said dedifferentiated chondrocytes in vitro with a medium comprising type II collagen, or its biologically active peptide fragment(s) or analogs with or without growth factor(s), wherein the type II collagen or its biologically active peptide fragment(s) or analogs are effective to restore chondrocyte phenotype and functions of, and/or to increase type II collagen and aggrecan expression levels and GAG accumulation level in the said dedifferentiated chondrocytes.
    Type: Application
    Filed: March 2, 2010
    Publication date: September 8, 2011
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: Yu-Hui Tsai, Li-Hsuan Chiu, Chin-Chean Wong, Wen-Fu Lai, Shih-Ching Chen