Abstract: A universal medication port includes a cylindrical member having an internal bore with a plurality of radial passageways extending therefrom. A plunger is disposed within the internal bore of the cylinder, the plunger having an internal bore with a plurality of radial passageways extending therefrom. The plunger is movable in response to insertion of a needle-less hypodermic syringe into the internal bore of the cylindrical member so as to align the respective passageways in the plunger and the cylindrical member with one another to establish a fluid path from the syringe through the internal bore of the plunger and respective passageways in the plunger and the cylindrical member to a receptacle, such as a vial, an intravenous bottle or intravenous delivery system, in which the cylindrical member is inserted.