Abstract: A rapid shaping and aseptically filling device has an extrusion mold head, two mold mechanisms, and at least one filling needle. The extrusion mold head has an annular outlet, a needle passing through hole, and a shaping area defined below the annular outlet. The annular outlet forms a plastic blank. The two mold mechanisms are respectively located in two sides of the shaping area. Each of the two mold mechanisms is annular and has multiple molds. The molds are capable of moving circularly and sequentially passing the shaping area to engage with each other and tightly clamp the plastic blank. The at least one filling needle is mounted in the needle passing through hole and is located in a center of the plastic blank. A bottom end of the at least one filling needle is located above top two of the molds which engage with each other.

Abstract: The present invention discloses a new process for the synthesis of tamsulosin and its aralkylamine derivatives, especially (R)-(?)-5-{2-[2-(2-alkoxyphenoxy) ethylamino]propyl}-2-alkoxybenzenesulfonamides having the following formula 1 (where R1 and R2 represent C1-C4 alkyl groups) and their hydrochloride thereof, and other various pharmaceutical used salts. Tamsulosin hydrochloride (R1=Et, R2=Me, in its hydrochloride salt form) is an antagonist of ?-A adrenoceptors in the prostate. Tamsulosin•HCl occurs as white crystals, which melt with decomposition at approximately 230° C. It is sparingly soluble in water and in methanol, slightly soluble in glacial acetic acid and in ethanol, and practically insoluble in ether.