Abstract: A lipid-based nanoparticle (LNP) with high DL ratio and normalized release. The LNP of the present invention comprises an outer lipid monolayer encapsulating a plurality of lipid-active pharmaceutical ingredient (API)-ion complexes, wherein each lipid-API-ion complex comprises a complex of anionic lipid, API and ion wherein the API comprises a positively charged form of an API and wherein the outer lipid monolayer of the LNP comprises neutral lipids. The present invention further comprises a method of preparation of the LNP of the present invention.

Abstract: A lipid-based nanoparticle (LNP) with high DL ratio and normalized release. The LNP of the present invention comprises an outer lipid monolayer encapsulating a plurality of lipid-active pharmaceutical ingredient (API) complexes, wherein each lipid-API complex comprises a complex of anionic lipid and API wherein the API comprises a positively charged form of an API and wherein the outer lipid monolayer of the LNP comprises neutral lipids. The present invention further comprises a method of preparation of the LNP of the present invention.

Abstract: The invention provides a method for treating target in need of such a treatments in a subject, comprising (a) administering a liposome containing a photosensitizer and a drug to a subject and (b) irradiating targets at least one time at appropriate time(s). In particular, the irradiation is performed at least two times.

Abstract: The invention provides a method for treating target in need of such a treatments in a subject, comprising (a) administering a liposome containing a photosensitizer and a drug to a subject and (b) irradiating targets at least one time at appropriate time(s). In particular, the irradiation is performed at least two times.

Abstract: The invention provides a dry powder microparticle for pulmonary delivery, which comprises at least one nanoparticle in the form of liposome or micelle wherein the nanopaparticle encapsulates one or more therapeutic agent therein, and a diluent layer surrounding the nanaparticles.

Abstract: The invention is directed to a microorganism-killing combination comprising a photosensitizer in an amount effective to kill microorganisms in a photodynamic process and a chitosan in an amount effective to enhance the microorganism-killing effect of the photosensitizer in the photodynamic process. The invention also provides the methods of administering the synergistic bacteria-killing combination to kill bacteria or treat infection.

Abstract: The present invention relates to a liposome combination, which wrapped hydrophilic drugs in water layer and wrapped hydrophobic drugs in lipid bilayer; hydrophobic drugs are photosensitizers. Using light with appropriate wavelength to activate the photosensitizer in the hydrophobic layer can result in the production of singlet oxygen and the free radical, and cause the oxidizing and breaking of the carbon chain of the phospholipid, and influences the stability of the liposome and the releases of the drug. The singlet oxygen and the free radical will attack the cancer cells at the same time as a result of combining the photodynamic- and chemo-effects.

Abstract: An irradiation apparatus for a photodynamic treatment. The irradiation apparatus includes a main body, a high power light emitting element, an optical lens assembly and an optical fiber. The high power light emitting element is disposed on the main body to output light. The optical lens assembly is adjacent to the high power light emitting element and disposed on the main body to receive the light from the high power light emitting element. The optical fiber has an input end and an output end. The input end is coupled to the optical lens assembly to receive and transmit the light from the optical lens assembly.

Abstract: A laser system providing a laser source suitable for medical PDT (Photodynamic Therapy) and PDD (Photodynamic Diagnosis) is purposed. The laser system includes a pump laser emitting at least one wavelength to pump a wavelength converter inside a laser resonating system; a wavelength converter using QPM (Quasi-Phase-Matching) technique to convert the wavelength emitted by the pump laser to at least one wavelength suitable for the PDT and the PDD; a laser resonating system for enhancing the output intensity of the laser suitable for the PDT and the PDD generated from the wavelength converter pumped by the pump laser; and an optical transmission and output device for receiving and transmitting the output laser from the laser resonator system to its end optical output component, through which at least one specific target is illuminated.