Patents by Inventor Chin-Tsyh Donald Chang

Chin-Tsyh Donald Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Trimethylglycylglycerin compositions and their use in developing anti-cancer drugs and RNA vaccines
    Patent number: 11326164
    Abstract: This invention generally relates to a group of novel chemical compositions and their use for formulating RNA- and/or DNA-based medicine drugs/vaccines into stable compound complexes useful for both in-vitro and in-vivo delivery. Particularly, the present invention teaches the synthesis of a group of novel trimethylglycyl chemicals and their use for formulating cosmetic, therapeutic- and/or pharmaceutical-grade nucleic acid compositions, including but not limited microRNA precursors (pre-miRNA/miRNA), small hairpin RNAs (shRNA), short interfering RNAs (siRNA), ribozymes, antisense oligonucleotides, RNA-DNA hybrids and DNA-based vectors/vaccines, with or without modification, into delivery complexes, which can then be absorbed by cells in vivo, ex vivo and/or in vitro through an active mechanism of endocytosis via acetylcoline receptors for releasing the therapeutic and pharmaceutical effects of the formulated nucleic acid compositions.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: May 10, 2022
    Inventors: Shi-Lung Lin, Samantha Chang-Lin, Chin-Tsyh Donald Chang
  • Novel Trimethylglycylglycerin Compositions and Their Use in Developing Anti-Cancer Drugs and RNA Vaccines
    Publication number: 20210095280
    Abstract: This invention generally relates to a group of novel chemical compositions and their use for formulating RNA- and/or DNA-based medicine drugs/vaccines into stable compound complexes useful for both in-vitro and in-vivo delivery. Particularly, the present invention teaches the synthesis of a group of novel trimethylglycyl chemicals and their use for formulating cosmetic, therapeutic- and/or pharmaceutical-grade nucleic acid compositions, including but not limited microRNA precursors (pre-miRNA/miRNA), small hairpin RNAs (shRNA), short interfering RNAs (siRNA), ribozymes, antisense oligonucleotides, RNA-DNA hybrids and DNA-based vectors/vaccines, with or without modification, into delivery complexes, which can then be absorbed by cells in vivo, ex vivo and/or in vitro through an active mechanism of endocytosis via acetylcoline receptors for releasing the therapeutic and pharmaceutical effects of the formulated nucleic acid compositions.
    Type: Application
    Filed: March 20, 2020
    Publication date: April 1, 2021
    Applicants: WJWU & LYNN Institute for Stem Cell Research, Mello Biotech Taiwan Co., Ltd.
    Inventors: Shi-Lung Lin, Samantha Chang-Lin, Chin-Tsyh Donald Chang