Abstract: A user of a network-based system may correspond to a user profile that describes the user. The user profile may describe the user using one or more descriptors of items that correspond to the user (e.g., items owned by the user, items liked by the user, or items rated by the user). In some situations, such a user profile may be characterized as a “taste profile” that describes an array or distribution of one or more tastes, preferences, or habits of the user. Accordingly, the user profile machine within the network-based system may generate the user profile by accessing descriptors of items that correspond to the user, clustering one or more of the descriptors, and generating the user profile based on one or more clusters of the descriptors.

Abstract: In one aspect, the disclosure relates to methods and compositions for treatment of cancer cachexia. In a further aspect, the composition is a pharmaceutical composition comprising a class I/IIB HDAC inhibitor and an androgen. In a still further aspect, the method of treatment comprises administering a class I/IIB HDAC inhibitor and an androgen to a subject or patient who has been diagnosed as having cancer cachexia. In some aspects, the class I/IIB HDAC inhibitor is a compound known as AR-42.

Abstract: A pen incorporated with an illuminator in which the positive terminal of the illuminator is connected to the positive terminal of the battery through a first switch, which is controlled by a pen top, and the negative terminal of the illuminator is connected to the negative terminal of the battery through the refill and a second switch, which is controlled by an insulative sleeve, and therefore the the illuminator is turned on when the refill is extended out of the pen for writing and the pen top is switched to the ON position; the illuminator does no work when the refill is extended out of the pen for writing and the pen top is switched to the OFF position.